Abstract: Simultaneous sample purification, enrichment and analysis of pharmaceuticals, illicit drugs, pollutants, biotechnological products, synthetic organic reaction products and food/flavor ingredients from complex matrices can be performed using porous hollow fiber or porous-disk liquid-membrane devices. The devices are part of a multi-well (e.g. 96-well) plate. The devices can be used for selective separation and enrichment of complex mixtures containing trace levels of analytes, and can be used in tandem with analytical instruments which routinely handle multiple samples under high throughput screening conditions. A multi-well/multi-vial plate can into state-of-the-art HPLC or GC sampling systems or LC/MS or GC/MS instruments. Samples can be enriched several orders of magnitude and can directly be withdrawn from the fiber and injected into the chromatographic instruments. Alternatively, these enriched samples can be introduced directly into MS, CE or other detection devices.

Abstract: The invention provides devices and methods for performing liquid phase microextraction of at least one analyte from an aqueous sample, wherein the device comprises a liquid membrane comprising a fatty acid ester, a vegetable oil, a silicone oil, a nitroarylalkylether, or mixtures thereof, and an optional carrier, supported on a porous polymeric substrate. In a preferred embodiment, the porous polymeric substrate is a hollow fiber. The devices and methods for preparing them provide stable liquid membranes for performing liquid phase microextraction, where the membranes can be stored for 30, 60 or 90 days prior to use.

Abstract: The invention provides devices and methods for performing liquid phase microextraction of at least one analyte from an aqueous sample, wherein the device comprises a liquid membrane comprising a fatty acid ester, a vegetable oil, a silicone oil, a nitroarylalkylether, or mixtures thereof, and an optional carrier, supported on a porous polymeric substrate. In a preferred embodiment, the porous polymeric substrate is a hollow fiber. The devices and methods for preparing them provide stable liquid membranes for performing liquid phase microextraction, where the membranes can be stored for 30, 60 or 90 days prior to use.

Abstract: Simultaneous sample purification, enrichment and analysis of pharmaceuticals, illicit drugs, pollutants, biotechnological products, synthetic organic reaction products and food/flavor ingredients from complex matrices can be performed using porous hollow fiber or porous-disk liquid-membrane devices. The devices are part of a multi-well (e.g. 96-well) plate. The devices can be used for selective separation and enrichment of complex mixtures containing trace levels of analytes, and can be used in tandem with analytical instruments which routinely handle multiple samples under high throughput screening conditions. A multi-well/multi-vial plate can into state-of-the-art HPLC or GC sampling systems or LC/MS or GC/MS instruments. Samples can be enriched several orders of magnitude and can directly be withdrawn from the fiber and injected into the chromatographic instruments. Alternatively, these enriched samples can be introduced directly into MS, CE or other detection devices.