Patents by Inventor Ko Chieh CHEN

Ko Chieh CHEN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Liposome compositions comprising weak acid drugs and uses thereof
    Patent number: 11964050
    Abstract: The present invention relates to a pharmaceutical composition comprising a weak acid drug, with the use of a bicarbonate salt to achieve a high incorporation of the drug into the liposome and a better therapeutic efficacy. Also disclosed is a method for treating a respiratory disease using the pharmaceutical composition disclosed herein.
    Type: Grant
    Filed: July 23, 2018
    Date of Patent: April 23, 2024
    Assignee: PHARMOSA BIOPHARM INC.
    Inventors: Pei Kan, Yi Fong Lin, Ko Chieh Chen
  • PHARMACEUTICAL COMPOSITION FOR CONTROLLED RELEASE OF TREPROSTINIL
    Publication number: 20240050387
    Abstract: Provided herein are pharmaceutical compositions containing (a) at least one liposome includes at least one vesicle-forming phospholipid; and (b) treprostinil encapsulated within the liposome. The ratio of treprostinil to phospholipid is equal to or higher than 0.035 and provides a controlled release of treprostinil. Also provided is the use of the pharmaceutical compositions to treat respiratory diseases.
    Type: Application
    Filed: October 24, 2023
    Publication date: February 15, 2024
    Inventors: Pei KAN, Yi Fong LIN, Ko Chieh CHEN
  • Pharmaceutical composition for controlled release of treprostinil
    Patent number: 11833125
    Abstract: Provided herein are pharmaceutical compositions containing (a) at least one liposome includes at least one vesicle-forming phospholipid; and (b) treprostinil encapsulated within the liposome. The ratio of treprostinil to phospholipid is equal to or higher than 0.035 and provides a controlled release of treprostinil. Also provided is the use of the pharmaceutical compositions to treat respiratory diseases.
    Type: Grant
    Filed: October 27, 2021
    Date of Patent: December 5, 2023
    Assignee: PHARMOSA BIOPHARM INC.
    Inventors: Pei Kan, Yi Fong Lin, Ko Chieh Chen
  • PHARMACEUTICAL COMPOSITION FOR CONTROLLED RELEASE OF TREPROSTINIL
    Publication number: 20220047537
    Abstract: Provided herein are pharmaceutical compositions containing (a) at least one liposome includes at least one vesicle-forming phospholipid; and (b) treprostinil encapsulated within the liposome. The ratio of treprostinil to phospholipid is equal to or higher than 0.035 and provides a controlled release of treprostinil. Also provided is the use of the pharmaceutical compositions to treat respiratory diseases.
    Type: Application
    Filed: October 27, 2021
    Publication date: February 17, 2022
    Inventors: Pei KAN, Yi Fong LIN, Ko Chieh CHEN
  • Pharmaceutical composition for controlled release of treprostinil
    Patent number: 11229616
    Abstract: Provided herein are pharmaceutical compositions containing (a) at least one liposome includes at least one vesicle-forming phospholipid; and (b) treprostinil encapsulated within the liposome. The ratio of treprostinil to phospholipid is equal to or higher than 0.035 and provides a controlled release of treprostinil. Also provided is the use of the pharmaceutical compositions to treat respiratory diseases.
    Type: Grant
    Filed: May 6, 2019
    Date of Patent: January 25, 2022
    Assignee: PHARMOSA BIOPHARM INC.
    Inventors: Pei Kan, Yi Fong Lin, Ko Chieh Chen
  • PHARMACEUTICAL COMPOSITION OF A WEAK ACID DRUG AND METHODS OF ADMINISTRATION
    Publication number: 20200360320
    Abstract: The present invention relates to a pharmaceutical composition containing liposomes, said liposome comprise an external lipid bilayer; and an internal aqueous medium including a weak acid drug with a half-life of less than 2 hours. Also provided is the use of the pharmaceutical composition disclosed herein to treat pulmonary hypertension with reduced dosing frequency.
    Type: Application
    Filed: May 13, 2020
    Publication date: November 19, 2020
    Inventors: Pei Kan, Yi Fong Lin, Ko Chieh Chen
  • PHARMACEUTICAL COMPOSITION FOR CONTROLLED RELEASE OF WEAK ACID DRUGS AND USES THEREOF
    Publication number: 20200085741
    Abstract: Provided herein are pharmaceutical compositions containing at least one liposome, said liposome comprise an external lipid bilayer including at least one vesicle-forming phospholipid and less than 15 mole % of sterol; and an internal aqueous medium including a weak acid drug and weak acid salt. The pharmaceutical compositions reduce the burst release of the weak acid drug. Also provided is the use of the pharmaceutical composition disclosed herein to treat respiratory diseases and reduce the side effect of the weak acid drug.
    Type: Application
    Filed: September 12, 2019
    Publication date: March 19, 2020
    Inventors: Pei KAN, Yi Fong LIN, Ko Chieh CHEN
  • PHARMACEUTICAL COMPOSITION FOR CONTROLLED RELEASE OF TREPROSTINIL
    Publication number: 20190336461
    Abstract: Provided herein are pharmaceutical compositions containing (a) at least one liposome includes at least one vesicle-forming phospholipid; and (b) treprostinil encapsulated within the liposome. The ratio of treprostinil to phospholipid is equal to or higher than 0.035 and provides a controlled release of treprostinil. Also provided is the use of the pharmaceutical compositions to treat respiratory diseases.
    Type: Application
    Filed: May 6, 2019
    Publication date: November 7, 2019
    Inventors: Pei KAN, Yi Fong LIN, Ko Chieh CHEN
  • LIPOSOME COMPOSITIONS COMPRISING WEAK ACID DRUGS AND USES THEREOF
    Publication number: 20190022004
    Abstract: The present invention relates to a pharmaceutical composition comprising a weak acid drug, with the use of a bicarbonate salt to achieve a high incorporation of the drug into the liposome and a better therapeutic efficacy. Also disclosed is a method for treating a respiratory disease using the pharmaceutical composition disclosed herein.
    Type: Application
    Filed: July 23, 2018
    Publication date: January 24, 2019
    Inventors: Pei KAN, Yi Fong LIN, Ko Chieh CHEN