Abstract: A display driver circuit for high resolution and high frame rate and a display device using the same are provided. A display driver circuit for high resolution and high frame rate includes a GAMMA output circuit, multiple digital-to-analog converters (DACs), multiple source operation amplifiers and at least a pre-charging circuit. The GAMMA output circuit outputs multiple grayscales of GAMMA voltages. Each DAC receives the GAMMA voltages and provides an output data voltage according to display data. Input terminals of the source operation amplifiers correspondingly coupled to output terminals of the DACs receive the corresponding output data voltages. The pre-charging circuit coupled between the input terminal of at least one of the source operation amplifiers and the output terminal of at least one of the DACs pre-charges the input terminal of the coupled source operation amplifier, so that an output terminal of the coupled source operation amplifier has fast response to the received output data voltage.