Patents by Inventor Kobi Chen

Kobi Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparation of statins with high syn to anti ratio
    Publication number: 20070179166
    Abstract: Provided is a process for reduction of statin ketoesters and purification of diol esters of the statins through selective crystallization.
    Type: Application
    Filed: September 12, 2006
    Publication date: August 2, 2007
    Inventors: Valerie Niddam-Hildesheim, Anna Balanov, Kobi Chen
  • Process for the preparation of rosuvastatin
    Publication number: 20070142418
    Abstract: The present invention provides a process for the preparation of the rosuvastatin intermediate FPP-CHO and its conversion to rosuvastatin and pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: February 7, 2007
    Publication date: June 21, 2007
    Inventors: Valerie Niddam-Hildesheim, Kobi Chen
  • Purification of montelukast
    Publication number: 20070078158
    Abstract: The present invention provides methods of purifying montelukast, a new isolated impurity of montelukast, method for its isolation, and method of using montelukast impurity as a reference marker and a reference standard.
    Type: Application
    Filed: July 5, 2006
    Publication date: April 5, 2007
    Inventors: Greta Sterimbaum, Evgeny Shapiro, Kobi Chen
  • Process for the preparation of rosuvastatin
    Patent number: 7179916
    Abstract: The present invention provides a process for the preparation of the rosuvastatin intermediate FPP—CHO and its conversion to rosuvastatin and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: July 13, 2005
    Date of Patent: February 20, 2007
    Assignee: Teva Pharmaceutical Industries Ltd.
    Inventors: Valerie Niddam-Hildesheim, Kobi Chen
  • Process for the preparation of rosuvastatin
    Publication number: 20060089501
    Abstract: The present invention provides a process for the preparation of the rosuvastatin intermediate FPP—CHO and its conversion to rosuvastatin and pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: July 13, 2005
    Publication date: April 27, 2006
    Inventors: Valerie Niddam-Hildesheim, Kobi Chen
  • Processes for preparing montelukast sodium
    Publication number: 20050256156
    Abstract: The present invention provides processes for preparing montelukast.
    Type: Application
    Filed: April 21, 2005
    Publication date: November 17, 2005
    Inventors: Evgeny Shapiro, Ronit Yahalomi, Valerie Niddam-Hildesheim, Greta Sterimbaum, Kobi Chen
  • Montelukast free acid polymorphs
    Publication number: 20050187243
    Abstract: The present invention relates to amorphous and polymorphic forms of montelukast free acid.
    Type: Application
    Filed: January 31, 2005
    Publication date: August 25, 2005
    Inventors: Valerie Niddam-Hildesheim, Judith Aronhime, Kobi Chen
  • Process for preparing 2-[(pyridinyl)methyl]sulfinyl-substituted benzimidazoles and novel chlorinated derivatives of pantoprazole
    Publication number: 20050075370
    Abstract: The present invention provides a process comprising admixing a thioether with about 1.05 to about 1.6 molar equivalents of an active chlorine-containing oxidant, preferably sodium hypochlorite, and about 2.5 to about 5.0 molar equivalents of an alkali metal base; and recovering a sulfoxide that is preferably pantoprazole, lansoprazole, omeprazole, or rabeprazole. The process may further comprise contacting the sulfoxide with a source of sodium ions, preferably sodium hydroxide, to produce the sodium salt of the sulfoxide. The invention also relates to novel chlorinated derivatives of pantoprazole including 5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)-chloromethyl]sulfinyl]-1H-benzimidazole and 5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)-chlorohydroxymethyl]sulfinyl]-1H-benzimidazole and processes for making them. The invention also relates to processes of quantifying and identifying a compound other than pantoprazole in a mixture of pantoprazole and at least one other compound.
    Type: Application
    Filed: June 10, 2004
    Publication date: April 7, 2005
    Inventors: Viviana Braude, Nina Finkelstein, Kobi Chen, Gideon Pilarsky, Anita Liberman, Claude Singer, Yuriy Raizi