Abstract: The present invention is directed to a nanoparticle including: a core of a metal chelating polymer, wherein the core is coated with at least two layers of magnetic metal oxide, which are further coated with a protein layer, and at least one active agent bound within or to the nanoparticle, methods for directing or targeting the nanoparticle via a magnetic field to a target tissue, and a computer program for efficiently generating the proper magnetic field for driving the nanoparticle to or into a given target tissue.