Patents by Inventor Kodzo Gbewonyo

Kodzo Gbewonyo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antioxidant and anti-inflammatory activity of compounds and preparations from African nutmeg seeds
    Patent number: 7371413
    Abstract: The present invention provides methods for reducing the production of nitric oxide, inducible nitric oxide synthase protein and mRNA, and cyclooxygenase-2 protein and mRNA in cells both in vivo and in vitro via the administration of extracts and compounds derived from the seeds of Pycnanthus angolensis Warb. (P. Kombo), commonly known as African nutmeg. These extracts and compounds, namely, kombo butter, kombo butter acid extract, sargaquinoic acid, sargachromenol, and sargahydroquinoic acid, are also useful in the treatment and prevention of a battery of adverse health conditions in human, animal, and avian subjects that are advanced by the production of nitric oxide or its metabolites and/or by the activity of cyclooxygenase-2. Methods for the isolation of kombo butter acid extracts are also provided.
    Type: Grant
    Filed: May 5, 2004
    Date of Patent: May 13, 2008
    Assignees: Rutgers, The State University, BioResources International Inc.
    Inventors: James E. Simon, Mingfu Wang, Kodzo Gbewonyo, Mohamed M. Rafi, Daniel Fahene Acquaye, Yaw Asianowa
  • Antioxidant and anti-inflammatory activity of compounds and preparations from African nutmeg seeds
    Publication number: 20050003030
    Abstract: The present invention provides methods for reducing the production of nitric oxide, inducible nitric oxide synthase protein and mRNA, and cyclooxygenase-2 protein and mRNA in cells both in vivo and in vitro via the administration of extracts and compounds derived from the seeds of Pycnanthus angolensis Warb. (P. Kombo), commonly known as African nutmeg. These extracts and compounds, namely, kombo butter, kombo butter acid extract, sargaquinoic acid, sargachromenol, and sargahydroquinoic acid, are also useful in the treatment and prevention of a battery of adverse health conditions in human, animal, and avian subjects that are advanced by the production of nitric oxide or its metabolites and/or by the activity of cyclooxygenase-2. Methods for the isolation of kombo butter acid extracts are also provided.
    Type: Application
    Filed: May 5, 2004
    Publication date: January 6, 2005
    Inventors: James Simon, Mingfu Wang, Kodzo Gbewonyo, Mohamed Rafi, Daniel Acquaye, Yaw Asianowa
  • Enantioselective bioreduction for the preparation of integrin receptor antagonist intermediates
    Patent number: 6764842
    Abstract: The present invention relates to a novel enantioselective bioreduction using a yeast microorganism for the preparation of the chiral allylic alcohols of structural formula I (R is hydrogen or methyl) which are useful in the asymmetric synthesis of integrin &agr;v&bgr;3 receptor antagonists.
    Type: Grant
    Filed: March 27, 2002
    Date of Patent: July 20, 2004
    Assignee: Merck & Co., Inc.
    Inventors: Michael G. Sturr, Russell Fieldon Boyd, Kodzo Gbewonyo, Joseph Nti-Gyabaah, David J. Pollard, James Christopher McWilliams, Kathleen A. Telari
  • Enantioselective bioreduction for the preparation of integrin receptor antagonist intermediates
    Publication number: 20020187988
    Abstract: The present invention relates to a novel enantioselective bioreduction using a yeast microorganism for the preparation of the chiral allylic alcohols of structural formula I (R is hydrogen or methyl) which are useful in the asymmetric synthesis of integrin &agr;v&bgr;3 receptor antagonists.
    Type: Application
    Filed: March 27, 2002
    Publication date: December 12, 2002
    Inventors: Michael G. Sturr, Russell Fieldon Boyd, Kodzo Gbewonyo, Joseph Nti-Gyabaah, David J. Pollard, James Christopher McWilliams, Kathleen A. Telari