Patents by Inventor Koen RAEMDONCK

Koen RAEMDONCK has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Particles comprising surfactant protein B and one or more lipids
    Patent number: 11213573
    Abstract: The present invention in particular relates to the field of micro- and nanoparticles, more in particular to coated nanoparticles. The coatings of the present invention in particular comprise surfactant protein B (SP-B) and one or more lipids. The invention further relates to such coated particles and compositions comprising them for use as a medicament, in particular for use in the treatment of various disorders. Furthermore, the invention provides the use of the compositions of the current invention for delivering one or more agents, such as small interfacing RNA (siRNA) molecules, to the target tissue or cells.
    Type: Grant
    Filed: November 23, 2017
    Date of Patent: January 4, 2022
    Assignees: UNIVERSITEIT GENT, UNIVERSIDAD COMPLUTENSE DE MADRID
    Inventors: Koen Raemdonck, Stefaan De Smedt, Jésus Pérez-Gil
  • Molecular adjuvants for enhanced cytosolic delivery of active agents
    Patent number: 11033572
    Abstract: The present invention relates to a method and compositions for optimized intracellular delivery of active agents, in particular nucleic acids, using a specific class of adjuvants. The method and compositions of the invention enhance cytosolic release of the agents and can be used for the treatment of various disorders.
    Type: Grant
    Filed: January 18, 2018
    Date of Patent: June 15, 2021
    Assignee: Universiteit Gent
    Inventors: Koen Raemdonck, Stefaan De Smedt
  • Method and system for characterizing extracellular vesicles
    Patent number: 10746730
    Abstract: A method for characterizing extracellular vesicles at an individual level is described. It comprises obtaining a sample comprising extracellular vesicles to be characterized and functionalizing the extracellular vesicles with plasmonic nanoparticles or a plasmonic coating. The method further comprises irradiating the individual extracellular vesicles with a laser beam and detecting a surface enhanced Raman spectroscopy signal from said individual extracellular vesicle.
    Type: Grant
    Filed: December 18, 2016
    Date of Patent: August 18, 2020
    Assignee: UNIVERSITEIT GENT
    Inventors: Kevin Braeckmans, Stephan Stremersch, Andre Skirtach, Stefaan De Smedt, Koen Raemdonck, Joseph Demeester, Juan Fraire
  • PARTICLES COMPRISING SURFACTANT PROTEIN B AND ONE OR MORE LIPIDS
    Publication number: 20200197496
    Abstract: The present invention in particular relates to the field of micro- and nanoparticles, more in particular to coated nanoparticles. The coatings of the present invention in particular comprise surfactant protein B (SP-B) and one or more lipids. The invention further relates to such coated particles and compositions comprising them for use as a medicament, in particular for use in the treatment of various disorders. Furthermore, the invention provides the use of the compositions of the current invention for delivering one or more agents, such as small interfacing RNA (siRNA) molecules, to the target tissue or cells.
    Type: Application
    Filed: November 23, 2017
    Publication date: June 25, 2020
    Inventors: Koen Raemdonck, Stefaan De Smedt, Jésus Pérez-Gil
  • MOLECULAR ADJUVANTS FOR ENHANCED CYTOSOLIC DELIVERY OF ACTIVE AGENTS
    Publication number: 20190328768
    Abstract: The present invention relates to a method and compositions for optimized intracellular delivery of active agents, in particular nucleic acids, using a specific class of adjuvants. The method and compositions of the invention enhance cytosolic release of the agents and can be used for the treatment of various disorders.
    Type: Application
    Filed: January 18, 2018
    Publication date: October 31, 2019
    Inventors: Koen Raemdonck, Stefaan De Smedt
  • METHOD AND SYSTEM FOR CHARACTERIZING EXTRACELLULAR VESICLES
    Publication number: 20180372730
    Abstract: A method for characterizing extracellular vesicles at an individual level is described. It comprises obtaining a sample comprising extracellular vesicles to be characterized and functionalizing the extracellular vesicles with plasmonic nanoparticles or a plasmonic coating. The method further comprises irradiating the individual extracellular vesicles with a laser beam and detecting a surface enhanced Raman spectroscopy signal from said individual extracellular vesicle.
    Type: Application
    Filed: December 18, 2016
    Publication date: December 27, 2018
    Inventors: Kevin BRAECKMANS, Stephan STREMERSCH, Andre SKIRTACH, Stefaan DE SMEDT, Koen RAEMDONCK, Joseph DEMEESTER, Juan FRAIRE