Patents by Inventor Koen Vandyck

Koen Vandyck has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anti-viral compounds
    Patent number: 12252481
    Abstract: Provided herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein) and methods of synthesizing the same. Also provided herein are methods of treating diseases and/or conditions with a compound of Formula (I), or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: October 13, 2023
    Date of Patent: March 18, 2025
    Assignees: Aligos Therapeutics, Inc., Katholieke Universiteit Leuven
    Inventors: Koen Vandyck, Dorothée Alice Marie-Eve Bardiot, Pierre Jean-Marie Bernard Raboisson, Leonid Beigelman, Antitsa Dimitrova Stoycheva, Sandro Boland, Arnaud Didier Marie Marchand
  • FUSED HETEROCYCLIC DERIVATIVES AND THEIR USE IN THE TREATMENT OF HBV INFECTION
    Publication number: 20250011326
    Abstract: The application describes fused heterocycle derivative compounds, pharmaceutical compositions comprising these compounds, chemical processes for preparing these compounds and their use in the treatment of diseases associated with HBV infection.
    Type: Application
    Filed: May 31, 2023
    Publication date: January 9, 2025
    Inventors: Lianzhu Liu, Gang Deng, Chunliang Lu, Bingqing Tang, Zhiguo Liu, Zhanling Cheng, Sandrine Céline Grosse, Koen Vandyck, Edgar Jacoby, Tim Hugo Maria Jonckers, Pierre Jean-Marie Bernard Raboisson, Scott D. Kuduk, Lindsey Graham Deratt
  • Modulators of THR-? and methods of use thereof
    Patent number: 12180192
    Abstract: Disclosed herein are compounds of Formula I: TL-La-CE-HD??(I) or a pharmaceutically acceptable salt, prodrug, amide or ester thereof, where i) TL is a moiety of Formula IIa, IIb, IIIa, IIIb, IIIc, or IIId; ii) CE is a moiety of Formula IV; iii) HD is a moiety of Formula V or VI; where the substituents are as defined herein. Disclosed are also pharmaceutical compositions comprising the above compounds, and methods of treating disease by administering or contact a patient with one or more of the above compounds.
    Type: Grant
    Filed: May 25, 2021
    Date of Patent: December 31, 2024
    Assignee: Aligos Therapeutics, Inc.
    Inventors: Koen Vandyck, Pierre Jean-Marie Bernard Raboisson, David McGowan, Jerome Deval
  • PYRIDAZINONE AND METHODS OF USE THEREOF
    Publication number: 20240368128
    Abstract: Disclosed herein are methods of modulating the activity of a thyroid hormone receptor beta and methods of treating disease using a pyridazinone compound.
    Type: Application
    Filed: May 5, 2023
    Publication date: November 7, 2024
    Applicant: ALIGOS THERAPEUTICS, INC.
    Inventors: David Craig McGowan, Pierre Jean-Marie Bernard Raboisson, Koen Vandyck, Jerome Deval
  • FUSED HETEROCYCLIC DERIVATIVES
    Publication number: 20240287070
    Abstract: The application describes fused heterocycle derivative compounds, pharmaceutical compositions comprising these compounds, chemical processes for preparing these compounds and their use in the treatment of diseases associated with HBV infection.
    Type: Application
    Filed: June 1, 2022
    Publication date: August 29, 2024
    Inventors: Chunliang LU, Xiaoyu LI, Lianzhu LIU, Gang DENG, Zhiguo LIU, Bingqing TANG, Wei CAI, Zhanling CHENG, Sandrine Céline GROSSE, Koen VANDYCK, Edgar JACOBY, Tim Hugo Maria JONCKERS, Pierre Jean-Marie Bernard RABOISSON, Scott D. KUDUK, Lindsey Graham DERATT
  • FUSED HETEROCYCLIC DERIVATIVES
    Publication number: 20240279227
    Abstract: The application describes fused heterocycle derivative compounds, pharmaceutical compositions comprising these compounds, chemical processes for preparing these compounds and their use in the treatment of diseases associated with HBV infection.
    Type: Application
    Filed: June 1, 2022
    Publication date: August 22, 2024
    Inventors: Chunliang LU, Gang DENG, Lianzhu LIU, Xiaoyu LI, Zhiguo LIU, Bingqing TANG, Wei CAI, Shane PLUNKETT, Philip James PYE, Lindsey Graham DERATT, Pierre Jean-Marie Bernard RABOISSON, Edgar JACOBY, Sandrine Céline GROSSE, Zhanling CHENG, Koen VANDYCK, Tim Hugo Maria JONCKERS, Scott D. KUDUK
  • Anti-viral compounds
    Patent number: 12065428
    Abstract: Provided herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein) and methods of synthesizing the same. Also provided herein are methods of treating diseases and/or conditions with a compound of Formula (I), or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: September 14, 2022
    Date of Patent: August 20, 2024
    Assignees: Aligos Therapeutics, Inc., Katholieke Universiteit Leuven
    Inventors: Dorothée Alice Marie-Eve Bardiot, Koen Vandyck, Sandro Boland, Antitsa Dimitrova Stoycheva, Arnaud Didier Marie Marchand, Pierre Jean-Marie Bernard Raboisson, Leonid Beigelman
  • ANTI-VIRAL COMPOUNDS
    Publication number: 20240199647
    Abstract: Provided herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein) and methods of synthesizing the same. Also provided herein are methods of treating diseases and/or conditions with a compound of Formula (I), or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: November 1, 2023
    Publication date: June 20, 2024
    Inventors: Dorothée Alice Marie-Eve Bardiot, Sandro Boland, Arnaud Didier Marie Marchand, Koen Vandyck, David McGowan, Leonid Beigelman, Antitsa Dimitrova Stoycheva
  • ANTI-VIRAL COMPOUNDS
    Publication number: 20240182444
    Abstract: Provided herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein) and methods of synthesizing the same. Also provided herein are methods of treating diseases and/or conditions with a compound of Formula (I), or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: October 16, 2023
    Publication date: June 6, 2024
    Inventors: Dorothée Alice Marie-Eve Bardiot, Sandro Boland, Arnaud Didier Marie Marchand, Koen Vandyck, David McGowan, Leonid Beigelman
  • Anti-viral compounds
    Patent number: 11952365
    Abstract: Provided herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein) and methods of synthesizing the same. Also provided herein are methods of treating diseases and/or conditions with a compound of Formula (I), or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: June 8, 2021
    Date of Patent: April 9, 2024
    Assignees: Aligos Therapeutics, Inc., Katholieke Universiteit Leuven
    Inventors: Koen Vandyck, Pierre Jean-Marie Bernard Raboisson, Leonid Beigelman, Vladimir Serebryany, Antitsa Dimitrova Stoycheva, Dorothée Alice Marie-Eve Bardiot, Sandro Boland, Arnaud Didier Marie Marchand
  • ANTI-VIRAL COMPOUNDS
    Publication number: 20240109871
    Abstract: Provided herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein) and methods of synthesizing the same. Also provided herein are methods of treating diseases and/or conditions with a compound of Formula (I), or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: October 13, 2023
    Publication date: April 4, 2024
    Inventors: Koen Vandyck, Dorothée Alice Marie-Eve Bardiot, Pierre Jean-Marie Bernard Raboisson, Leonid Beigelman, Antitsa Dimitrova Stoycheva, Sandro Boland, Arnaud Didier Marie Marchand
  • ANTI-VIRAL COMPOUNDS
    Publication number: 20240018126
    Abstract: Provided herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein) and methods of synthesizing the same. Also provided herein are methods of treating diseases and/or conditions with a compound of Formula (I), or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: July 5, 2023
    Publication date: January 18, 2024
    Inventors: Koen Vandyck, Dorothée Alice Marie-Eve Bardiot, Pierre Jean-Marie Bernard Raboisson, Leonid Beigelman, Antitsa Dimitrova Stoycheva, Sandro Boland, Arnaud Didier Marie Marchand
  • Bicyclic pyridazinones and methods of use thereof
    Patent number: 11858913
    Abstract: Disclosed herein are compounds of Formula I: or a stereoisomer or a tautomer thereof, or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising such compounds, and methods of treating disease by administering or contacting a subject with one or more of the above compounds.
    Type: Grant
    Filed: November 5, 2021
    Date of Patent: January 2, 2024
    Assignee: Aligos Therapeutics, Inc.
    Inventors: David Craig McGowan, Pierre Jean-Marie Bernard Raboisson, Koen Vandyck, Jerome Deval, Leonid Beigelman
  • Anti-viral compounds
    Patent number: 11851422
    Abstract: Provided herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein) and methods of synthesizing the same. Also provided herein are methods of treating diseases and/or conditions with a compound of Formula (I), or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: July 6, 2022
    Date of Patent: December 26, 2023
    Assignees: Katholieke Universiteit Leuven
    Inventors: Koen Vandyck, Dorothée Alice Marie-Eve Bardiot, Pierre Jean-Marie Bernard Raboisson, Leonid Beigelman, Antitsa Dimitrova Stoycheva, Sandro Boland, Arnaud Didier Marie Marchand
  • Modulators of THR-? and methods of use thereof
    Patent number: 11840532
    Abstract: Disclosed herein are compounds of Formula I?: or a stereoisomer or a tautomer thereof, or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising such compounds, and methods of treating disease by administering or contacting a patient with one or more of the above compounds.
    Type: Grant
    Filed: July 8, 2021
    Date of Patent: December 12, 2023
    Assignee: Aligos Therapeutics, Inc.
    Inventors: David Craig McGowan, Pierre Jean-Marie Bernard Raboisson, Koen Vandyck, Jerome Deval
  • Oxindoles and methods of use thereof
    Patent number: 11793815
    Abstract: Disclosed herein are compounds of Formula I?: or a stereoisomer or a tautomer thereof, or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising such compounds, and methods of treating disease by administering or contacting a subject with one or more of the above compounds.
    Type: Grant
    Filed: November 5, 2021
    Date of Patent: October 24, 2023
    Assignee: Aligos Therapeutics, Inc.
    Inventors: David Craig McGowan, Pierre Jean-Marie Bernard Raboisson, Koen Vandyck, Jerome Deval, Leonid Beigelman
  • 2-pyridones and methods of use thereof
    Patent number: 11786532
    Abstract: Disclosed herein are compounds of Formula I?: or a stereoisomer or a tautomer thereof, or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising such compounds, and methods of treating disease by administering or contacting a subject with one or more of the above compounds.
    Type: Grant
    Filed: November 5, 2021
    Date of Patent: October 17, 2023
    Assignee: Aligos Therapeutics, Inc.
    Inventors: David Craig McGowan, Pierre Jean-Marie Bernard Raboisson, Koen Vandyck, Jerome Deval, Leonid Beigelman
  • ANTI-VIRAL COMPOUNDS
    Publication number: 20230140238
    Abstract: Provided herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein) and methods of synthesizing the same. Also provided herein are methods of treating diseases and/or conditions with a compound of Formula (I), or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: September 14, 2022
    Publication date: May 4, 2023
    Inventors: Dorothée Alice Marie-Eve Bardiot, Koen Vandyck, Sandro Boland, Antitsa Dimitrova Stoycheva, Arnaud Didier Marie Marchand, Pierre Jean-Marie Bernard Raboisson, Leonid Beigelman
  • FUSED RING PYRIMIDONE DERIVATIVES FOR USE IN THE TREATMENT OF HBV INFECTION OR OF HBV-INDUCED DISEASES
    Publication number: 20230091047
    Abstract: The present application relates to compounds according to Formula (I), pharmaceutical compositions comprising at least one of said compounds, their use as a medicament, and their use in treating chronic hepatitis B virus (HBV) infection. The disclosure further pertains to methods for preparing compounds according to Formula (I).
    Type: Application
    Filed: March 13, 2020
    Publication date: March 23, 2023
    Inventors: Sandrine Céline GROSSE, Jan Martin BERKE, Meng-yang HSIAO, Lili HU, Edgar JACOBY, Tim Hugo Maria JONCKERS, Bart Rudolf Romanie KESTELEYN, Stefaan Julien LAST, Carlolina MARTINEZ LAMENCA, Mathieu PERRIER, Serge Maria Aloysius PIETERS, Pierre Jean-Marie Bernard RABOISSON, Abdellah TAHRI, Koen VANDYCK, Wim Gaston VERSCHUEREN
  • ANTI-VIRAL COMPOUNDS
    Publication number: 20230093249
    Abstract: Provided herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein) and methods of synthesizing the same. Also provided herein are methods of treating diseases and/or conditions with a compound of Formula (I), or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: July 6, 2022
    Publication date: March 23, 2023
    Inventors: Koen Vandyck, Dorothée Alice Marie-Eve Bardiot, Pierre Jean-Marie Bernard Raboisson, Leonid Beigelman, Antitsa Dimitrova Stoycheva, Sandro Boland, Arnaud Didier Marie Marchand