Patents by Inventor Koen Weterings

Koen Weterings has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • plants deficient in fucosyltransferase activity
    Patent number: 10196664
    Abstract: The invention provides methods for reducing the levels of alfa (1,3)-fucosylated N-glycans on glycoproteins produced in plants or plant cells. In addition, the invention provides alfa(1,3)-fucosyltransferase genes from Nicotiana benthamiana, and mutant N. benthamiana plants in which the levels of alfa(1,3)-fucosylated N-glycans are reduced.
    Type: Grant
    Filed: October 4, 2012
    Date of Patent: February 5, 2019
    Assignee: Icon Genetics GmbH
    Inventors: Koen Weterings, Gerben Van Eldik
  • Methods and means to modify a plant genome
    Patent number: 9670496
    Abstract: Methods and means are provided to modify in a targeted manner the genome of a plant in close proximity to an existing elite event using a double stranded DNA break inducing enzyme. Also provided are plants, in particular cotton plants showing tolerance to a field dose of at least 1× of at least one HPPD inhibitor, and methods for making such plants.
    Type: Grant
    Filed: March 7, 2014
    Date of Patent: June 6, 2017
    Assignees: Bayer CropScience N.V., Bayer CropScience AG, Bayer CropScience LP
    Inventors: Kathleen D'Halluin, Jan Dittgen, Stefan Jansens, Frank Meulewaeter, Koen Weterings, Hal Moser, Thomas Wilde, Ruediger Hain, Udo Bickers, Linda Trolinder, Gary Henniger
  • Production of galactosylated N-glycans in plants
    Patent number: 9181532
    Abstract: The invention provides methods for increasing the levels of bi-antennary mono- and fully galactosylated N-glycans, and for decreasing the levels of hybrid-type galactosylated N-glycans on glycoproteins produced in plants or plant cells. In addition, the invention provides methods for the production of heterologous glycoproteins with increased levels of bi-antennary mono- and fully galactosylated N-glycans, or decreased levels of hybrid-type galactosylated N-glycans in plants or plant cells.
    Type: Grant
    Filed: July 27, 2012
    Date of Patent: November 10, 2015
    Assignee: Icon Genetics GmbH
    Inventors: Koen Weterings, Sylvie Van Herrewege
  • NICOTIANA BENTHAMIANA PLANTS DEFICIENT IN FUCOSYLTRANSFERASE ACTIVITY
    Publication number: 20150080553
    Abstract: The invention provides methods for reducing the levels of alfa (1,3)-fucosylated N-glycans on glycoproteins produced in plants or plant cells. In addition, the invention provides alfa(1,3)-fucosyltransferase genes from Nicotiana benthamiana, and mutant N. benthamiana plants in which the levels of alfa(1,3)-fucosylated N-glycans are reduced.
    Type: Application
    Filed: October 4, 2012
    Publication date: March 19, 2015
    Inventors: Koen Weterings, Gerben Van Eldik
  • plants deficient in xylosyltransferase activity
    Patent number: 8933297
    Abstract: The invention provides Nicotiana benthamiana mutant plants which are incapable of forming xylosyl-structures on glycoproteins. In addition, the invention provides methods for the production of heterologous glycoproteins in said mutant plants.
    Type: Grant
    Filed: June 10, 2010
    Date of Patent: January 13, 2015
    Assignee: Icon Genetics GmbH
    Inventors: Koen Weterings, Gerben Van Eldik
  • METHODS AND MEANS TO MODIFY A PLANT GENOME
    Publication number: 20140196169
    Abstract: Methods and means are provided to modify in a targeted manner the genome of a plant in close proximity to an existing elite event using a double stranded DNA break inducing enzyme. Also provided are plants, in particular cotton plants showing tolerance to a field dose of at least 1× of at least one HPPD inhibitor, and methods for making such plants.
    Type: Application
    Filed: March 7, 2014
    Publication date: July 10, 2014
    Applicants: BAYER CROPSCIENCE NV, BAYER CROPSCIENCE LP, BAYER CROPSCIENCE AG
    Inventors: Kathleen D'HALLUIN, Jan DITTGEN, Stefan JANSENS, Frank MEULEWAETER, Koen WETERINGS, Hal MOSER, Thomas WILDE, Ruediger HAIN, Udo BICKERS, Linda TROLINDER, Gary HENNIGER
  • PRODUCTION OF GALACTOSYLATED N-GLYCANS IN PLANTS
    Publication number: 20130052683
    Abstract: The invention provides methods for increasing the levels of bi-antennary mono- and fully galactosylated N-glycans, and for decreasing the levels of hybrid-type galactosylated N-glycans on glycoproteins produced in plants or plant cells. In addition, the invention provides methods for the production of heterologous glycoproteins with increased levels of bi-antennary mono- and fully galactosylated N-glycans, or decreased levels of hybrid-type galactosylated N-glycans in plants or plant cells.
    Type: Application
    Filed: July 27, 2012
    Publication date: February 28, 2013
    Applicant: ICON GENETICS GMBH
    Inventors: Koen Weterings, Sylvie Van Herrewege
  • Production of Multi-Antennary N-Glycan Structures in Plants
    Publication number: 20120283420
    Abstract: The invention provides methods for producing multi-antennary glycoproteins in plant and plant cells. In particular the invention provides plants comprising a chimeric gene comprising glucosaminyltransferase IV and plants comprising two chimeric genes comprising glucosaminyltransferase IV and V.
    Type: Application
    Filed: April 19, 2010
    Publication date: November 8, 2012
    Inventors: Bieke Nagels, Koen Weterings
  • Nicotiana Benthamiana Plants Deficient in Xylosyltransferase Activity
    Publication number: 20120083014
    Abstract: The invention provides Nicotiana benthamiana mutant plants which are incapable of forming xylosyl-structures on glycoproteins. In addition, the invention provides methods for the production of heterologous glycoproteins in said mutant plants.
    Type: Application
    Filed: June 10, 2010
    Publication date: April 5, 2012
    Inventors: Koen Weterings, Gerben Van Eldik
  • Novel Nucleotide Sequences Encoding Nicotiana Beta-1,2-Xylosyltransferase
    Publication number: 20100287657
    Abstract: Provided are novel ?1,2-xylosyltransferase nucleotide sequences and uses thereof.
    Type: Application
    Filed: March 15, 2007
    Publication date: November 11, 2010
    Applicant: Bayer BioScience N.V.
    Inventor: Koen Weterings
  • METHOD TO PRODUCE MODIFIED PLANTS WITH ALTERED N-GLYCOSYLATION PATTERN
    Publication number: 20100242128
    Abstract: Provided is a novel method to produce a plant cell or plant having an altered N-glycosylation pattern resulting, in particular, in a low level of ?-1,2-xylose residues and core ?-1,3-fucose residues on protein-bound N-glycans. The plant cell or plant is of particular interest for producing therapeutic glycoproteins with a low, or not detectable, level of ?-1,2-xylose and ?-1,3-fucose residues. Also provided are novel ?-1,3-fucosyltransferase nucleotide sequences and uses.
    Type: Application
    Filed: October 31, 2007
    Publication date: September 23, 2010
    Applicant: Bayer BioSceince NV
    Inventors: Herta Steinkellner, Richard Strasser, Josef Glössl, Koen Weterings, Gerben Van Eldik
  • METHODS AND MEANS FOR PRODUCING GLYCOPROTEINS WITH ALTERED GLYCOSYLATION PATTERN IN HIGHER PLANTS
    Publication number: 20100154081
    Abstract: The invention provides methods to modify the N-glycosylation pattern of glycoproteins in higher plant cells, through reducing or eliminating the level of ?(1,2) xylosyltransferase and ? (1,3) fucosyltransferase activity and increasing the ?(1,4) galactosyltransferase activity in the cell of the higher plant.
    Type: Application
    Filed: May 20, 2008
    Publication date: June 17, 2010
    Applicant: BAYER BIOSCIENCE N.V.
    Inventors: Koen Weterings, Gerben Van Eldik, Bicke Nagels
  • Polynucleotides useful for modulating transcription
    Patent number: 6855866
    Abstract: The invention provides polynucleotides for expression of genes in suspensor cells in plants and methods for using such polynucleotides.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: February 15, 2005
    Assignee: The Regents of the University of California
    Inventors: Koen Weterings, Nestor R. Apuya, Robert B. Goldberg
  • Polynucleotides useful for modulating transcription
    Publication number: 20030061632
    Abstract: The invention provides polynucleotides for expression of genes in suspensor cells in plants and methods for using such polynucleotides.
    Type: Application
    Filed: November 28, 2001
    Publication date: March 27, 2003
    Inventors: Koen Weterings, Nestor R. Apuya, Tatiana Tatarinova, Robert B. Goldberg