Patents by Inventor Koenraad Van Acker

Koenraad Van Acker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • (1,10B-Dihydro-2-(Aminocarbonyl-Phenyl)-5h-Pyrazolo[1,5-C][1,3]Benzoxazin-5-Yl)Phenyl Methanone Derivatives as Hiv Viral Replication Inhibitors
    Publication number: 20070248624
    Abstract: The present invention relates to 5H-pyrazolo[1,5-c][1,3]benzoxazin-5-yl)phenyl methanone derivatives as inhibitors of the viral replication of the HIV virus, processes for their preparation as well as pharmaceutical compositions, their use as medicines, and diagnostic kits comprising them. The present invention also concerns combinations of the present HIV inhibitors with other anti-retroviral agents. It further relates to their use in assays as reference compounds or as reagents. The compounds of the present invention are useful for preventing or treating infection by HIV and for treating AIDS.
    Type: Application
    Filed: May 4, 2005
    Publication date: October 25, 2007
    Inventors: Abdellah Tahri, Lieve Emma Jan Michiels, Koenraad Van Acker, Dominique Louis Nestor Ghislain Surleraux
  • Entry inhibitors of the hiv virus
    Publication number: 20070066623
    Abstract: The present invention relates to small molecules as entry inhibitors of the HIV virus, processes for their preparation as well as pharmaceutical compositions, their use as medicines, and diagnostic kits comprising them. The present invention also concerns combinations of the present entry inhibitors with other anti-retroviral agents. It further relates to their use in assays as reference compounds or as reagents. The compounds of the present invention are useful for preventing or treating infection by HIV and for treating AIDS.
    Type: Application
    Filed: September 10, 2004
    Publication date: March 22, 2007
    Inventors: Koenraad Van Acker, Piet Wigerinck, Lieve Michiels, Abdellah Tahri
  • Fluorogenic enzyme substrates and methods of preparation
    Publication number: 20070037234
    Abstract: This invention relates to hydrolase fluorogenic substrates with improved cell permeability, methods for the preparation thereof, and methods of measuring activities of hydrolases, particularly in cell-based assays. The substrates easily diffuse into the cells, where they are enzymatically processed to yield photostable fluorescent products, and are particularly fitted for visualising enzyme-derived activities in cell-based assays.
    Type: Application
    Filed: December 26, 2003
    Publication date: February 15, 2007
    Inventors: Jan Goeman, Koenraad Van Acker, Johan Van Der Eycken, Inge Dierynck
  • Time-of-addition assay for identifying anti-viral compounds
    Publication number: 20060286547
    Abstract: The present invention relates to a multi-well assay for identifying a compound inhibiting the replication cycle of a micro-organism, for example, HIV, and to an apparatus for carrying out an assay according to the present invention. The invention further relates to compounds identifiable with an assay according to the invention and pharmaceutical compositions comprising a therapeutically effective amount of such compounds. The identified compounds may be used as medicaments, and in particular for the manufacture of a medicament for treating infectious diseases and in method for treating infectious diseases including AIDS.
    Type: Application
    Filed: September 20, 2004
    Publication date: December 21, 2006
    Inventors: Koenraad Van Acker, Lieve Bunkens, Gery Dams, Kurt Hertogs, Tania Ivens, Erik Nijs