Patents by Inventor Koert Gerzon

Koert Gerzon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Derivatives of ryanodine and dehydroryanodine
    Patent number: 5679701
    Abstract: Novel O.sub.10eq -derivatives of ryanodine and dehydroryanodine characterized as binding strongly to ryanodine receptor, useful in affecting Ca.sup.++ efflux in tissue and also in isolating ryanodine receptor from sarcoplasmic reticulum. Also described are novel radio-iodinated alanine derivatives useful to radio label ryanodine and dehydroryanodine derivatives.
    Type: Grant
    Filed: April 23, 1996
    Date of Patent: October 21, 1997
    Assignee: Indiana University Foundation
    Inventors: Koert Gerzon, Rod A. Humerickhouse, Henry R. Besch, Jr., Keshore R. Bidasee
  • Derivatives of ryanodine and dehydroryanodine
    Patent number: 5510500
    Abstract: Novel O.sub.10eq -derivatives of ryanodine and dehydroryanodine characterized as binding strongly to ryanodine receptor, useful in affecting Ca.sup.++ efflux in tissue and also in isolating ryanodine receptor from sarcoplasmic reticulum. Also described are novel radio-iodinated alanine derivatives useful to radio label ryanodine and dehydroryanodine derivatives.
    Type: Grant
    Filed: May 17, 1995
    Date of Patent: April 23, 1996
    Assignee: Indiana University Foundation
    Inventors: Koert Gerzon, Rod A. Humerickhouse, Henry R. Besch, Jr., Keshore R. Bidasee
  • Derivatives of ryanodine and dehydroryanodine
    Patent number: 5432288
    Abstract: Novel O.sub.10eq -derivatives of ryanodine and dehydroryanodine characterized as binding strongly to ryanodine receptor, useful in affecting Ca.sup.++ efflux in tissue and also in isolating ryanodine receptor from sarcoplasmic reticulum. Also described are novel radio-iodinated alanine derivatives useful to radio label ryanodine and dehydroryanodine derivatives.
    Type: Grant
    Filed: March 2, 1993
    Date of Patent: July 11, 1995
    Assignee: Indiana University Foundation
    Inventors: Koert Gerzon, Rod A. Humerickhouse, Henry R. Bensch, Jr., Keshore R. Bidasee
  • Use of vindesine in treating acute lymphatic leukemia and _other susceptible neoplasms
    Patent number: 4479957
    Abstract: This invention relates to a method of treating neoplasms which comprises administering to a mammal suffering from a vindesinesusceptible neoplasm selected from the group consisting of acute lymphatic leukemia, acute granulocytic leukemia, chronic myeloid leukemia, non-small cell lung cancer, Hodgkin's disease, non-Hodgkin's lymphoma, malignant melanoma carcinoma of the breast, esophageal carcinoma and testicular carcinoma an anti-neoplastically-effective amount of vindesine or a pharmaceutically-acceptable acid addition salt thereof.
    Type: Grant
    Filed: April 2, 1981
    Date of Patent: October 30, 1984
    Assignee: Eli Lilly and Company
    Inventors: George J. Cullinan, Koert Gerzon
  • Herpes treatment
    Patent number: 4415590
    Abstract: L-lysine L-glutamate, when injected intradermally in the form of a sterile aqueous solution, or applied topically in the form of a cream, ointment, or lotion, is effective for treating and relieving the symptons of Herpes simplex I and II infections.
    Type: Grant
    Filed: April 26, 1982
    Date of Patent: November 15, 1983
    Assignee: BetaMED Pharmaceuticals, Inc.
    Inventor: Koert Gerzon
  • Vinblastine oxazolidinedione disulfides and related compounds
    Patent number: 4362664
    Abstract: Thioalkyl derivatives of vinblastine 3-spiro-5"-oxazolidine-2",4"-dione, mitotic inhibitors.
    Type: Grant
    Filed: December 29, 1980
    Date of Patent: December 7, 1982
    Assignee: Eli Lilly and Company
    Inventors: Koert Gerzon, Jean C. Miller
  • Antineoplastic 4'-formylamino and 4'-acetylamino VLB, and derivatives thereof
    Patent number: 4322351
    Abstract: 4'-Substituted VLB and vincristine, 4-desacetyl VLB, 4-desacetylvincristine and amides and hydrazides thereof, prepared by action of HCN or acetonitrile under strongly acidic conditions.
    Type: Grant
    Filed: August 25, 1980
    Date of Patent: March 30, 1982
    Assignee: Eli Lilly and Company
    Inventors: Jean C. Miller, Koert Gerzon
  • Amide derivatives of VLB, leurosidine, leurocristine and related dimeric alkaloids
    Patent number: 4203898
    Abstract: Amide derivatives of VLB, leurosidine, leurocristine and related dimeric alkaloids are useful as anti viral and anti-neoplastic agents or as intermediates in the preparation of such agents.
    Type: Grant
    Filed: October 25, 1978
    Date of Patent: May 20, 1980
    Assignee: Eli Lilly and Company
    Inventors: George J. Cullinan, Koert Gerzon
  • Bridged cathranthus alkaloid dimers
    Patent number: 4199504
    Abstract: Bridged vinca dimers in which two indole-dihydro-indole C-3 carboxamides are linked through the nitrogen atom of a carboxamide group, useful as oncolytic agents.
    Type: Grant
    Filed: May 15, 1978
    Date of Patent: April 22, 1980
    Assignee: Eli Lilly and Company
    Inventors: Robert A. Conrad, Koert Gerzon
  • Amides of leurosine, leuroformine, desacetylleurosine and desacetylleuroformine
    Patent number: 4191688
    Abstract: C-3 Carboxamides of leurosine, leuroformine, 4-desacetylleurosine and 4-desacetylleuroformine, useful as antitumor agents.
    Type: Grant
    Filed: June 12, 1978
    Date of Patent: March 4, 1980
    Assignee: Eli Lilly and Company
    Inventors: Robert A. Conrad, George J. Cullinan, Jean C. Miller, Koert Gerzon
  • Derivatives of 4-desacetyl VLB C-3 carboxyhydrazide
    Patent number: 4166810
    Abstract: N.sup.2 derivatives of 4-desacetyl VLB (vinblastine) C-3 carboxyhydrazide, active anti-tumor agents.
    Type: Grant
    Filed: April 20, 1978
    Date of Patent: September 4, 1979
    Assignee: Eli Lilly and Company
    Inventors: George J. Cullinan, Koert Gerzon
  • Method for treating psoriasis
    Patent number: 3937822
    Abstract: Psoriasis is treated topically, orally or parenterally with pyrazofurin.
    Type: Grant
    Filed: July 22, 1974
    Date of Patent: February 10, 1976
    Assignee: Eli Lilly and Company
    Inventors: Donald C. DeLong, Koert Gerzon