Abstract: A viral mutation prediction device has an acquisition unit which acquires gene sequence data of a genome of a virus, an extraction unit which extracts C (cytosine) or G (guanine) from the acquired gene sequence data of the genome and extracts contexts in which a mutation from C or G to U (uracil) occurs or has occurred, a separation unit which checks whether there is an amino acid mutation when C or G has changed to U and which separates sequences with the amino acid mutation as nonsynonymous substitutions and separates sequences without the amino acid mutation as synonymous substitutions, a learning unit which learns using the sequence data of the synonymous substitutions for learning data and a prediction unit which predicts a mutation of the virus using the learned results.

Abstract: To provide a therapy and a diagnosis of cancer or an infection using recognition mechanism of a T-cell receptor.

Abstract: Provided is a method for treating and diagnosing an autoimmune disease, organ transplant rejection and allergic disease by using a method of regulating antigen-specific MHC expression. An agent for decreasing T-cell function for suppressing an autoimmune disease, organ transplant rejection or allergic disease, having a T-cell receptor or chimeric protein being a fusion protein of a T-cell receptor variable region recognizing a complex of an autoimmune disease-specific antigen and an MHC molecule, a complex of a specific antigen causing an organ transplant rejection and an MHC molecule, or a complex of an allergic disease-specific antigen and an MHC molecule and an immunoglobulin Fc region, as an active ingredient; and regulating expression of the MHC molecule.

Abstract: The present invention is intended to provide a method of amplifying a target gene without bias and an adapter DNA use therefor. The adapter DNA of the present invention is double-stranded adapter DNA, which is used for unbiased gene amplification.

Abstract: To provide a therapy and a diagnosis of cancer or an infection using recognition mechanism of a T-cell receptor.

Abstract: The present invention is intended to provide a method of amplifying a target gene without bias and an adapter DNA use therefor.

Abstract: The present invention relates to methods and compositions for treating and/or preventing inflammation associated with viral infection and solid organ transplant rejection. In particular, the present invention provides therapeutics for impairing the expansion and function of autoreactive T cells, NK cells and/or NKT cells, by modulating NKG2D.

Abstract: The present invention relates to methods and compositions for treating and/or preventing autoimmune and/or inflammatory disease. In particular, the present invention provides therapeutics for impairing the expansion and function of autoreactive T cells, NK cells and/or NKT cells, by modulating NKG2D.

Abstract: The present invention relates to methods and compositions for treating and/or preventing autoimmune and/or inflammatory disease. In particular, the present invention provides therapeutics for impairing the expansion and function of autoreactive T cells, NK cells and/or NKT cells, by modulating NKG2D.

Abstract: The present invention relates to methods and compositions for treating or preventing autoimmune and/or inflammatory disease. In particular, the present invention provides therapeutics for impairing the expansion and function of autoreactive T cells and/or NK cells, by modulating NKG2D.