Abstract: The purpose of the present invention is to provide a novel stereoselective method for preparing a cyclic dinucleotide derivative and a production intermediate therefor, which can be used for an antibody-immunostimulant conjugate. Also provided is a method for producing a cyclic dinucleotide-linker and an antibody-immunostimulant conjugate while using the above production method. Further provided is a method for preparing a cyclic dinucleotide derivative, the method including the step of subjecting a compound (I) and a compound (IV) to stereoselective condensation using an optically active phosphitylating agent (Rc-II) or (Sc-II).

Abstract: The purpose of the present disclosure is to provide a method for manufacturing a polyimide (PI) precursor resin composition that has excellent resolution performance, a broad range of available exposure and good handling properties. Provided is a method for manufacturing a PI precursor resin composition that comprises a PI precursor resin, an exposure light absorber, a photopolymerization initiator and a solvent. The PI precursor resin is selected from among materials having an absorbance parameter Xp for a light species within a range of 0.001-0.20, the exposure light absorber is selected from among materials having an absorbance parameter Xt for the light species within a range of 0.01-0.05, and the photopolymerization initiator is selected from among materials having an absorbance parameter Xr for the light species within a range of 0-0.04.

Abstract: A hydraulic excavator is provided which can suppress the fuel consumption amount and improve the work efficiency by reducing the hydraulic pressure loss generated when a plurality of hydraulic actuators different in load are operated simultaneously.

Abstract: [Problem] In a control system for a work vehicle, safety when a backward work permission switch is operated OFF is further enhanced. [Solution] A control system for a work vehicle includes a control device that controls driving of a work implement in accordance with an operation of a work operation unit and forcibly stops the work implement when the work vehicle travels backward, and a backward work permission switch that disables forced stopping of the work implement at a start of backward traveling of the work vehicle by an ON operation performed by a user.

Abstract: An electric work vehicle includes at least one motor configured to drive one or both of a travelling device and a working device included in a vehicle; an operation section configured to direct a rotational speed or actuation of the motor; a control section configured to control the motor according to an operation of the operation section; and a battery configured to supply power to the motor. The control section decreases an upper limit of rotational speed of the motor, based on a detected result with regard to a battery condition including a voltage of the battery.

Abstract: A work machine includes a flow control valve that controls a flow rate of a hydraulic fluid supplied to a hydraulic actuator, a center bypass line that introduces the hydraulic fluid from a pump through a center bypass passage section of the flow control valve into the tank, a bypass cutoff valve that controls an opening of the center bypass line, a solenoid proportional valve that generates a pilot pressure for controlling the bypass cutoff valve, a pilot valve that generates a pilot pressure for controlling the flow control valve on the basis of an amount of operation of an operation device, and a controller that controls the solenoid proportional valve on the basis of the amount of operation.

Abstract: A transmission structure of the present invention causes, during a period from a time point when a rotational speed of a drive rotational power reaches a predetermined first/second speed stage shift-up start speed until a first/second speed stage shift-up end time point, one of an input-side clutch mechanism pair and an output-side clutch mechanism pair to be in a double transmitting state, and causes, in the double transmitting state, a first clutch mechanism and a second clutch mechanism of the other one of the input-side clutch mechanism pair and the output-side clutch mechanism pair to be shifted to a disengagement sate and an engagement state, respectively, while having frictional plate slid.

Abstract: An electric work vehicle includes a traveling motor to drive wheels, a working motor to drive a work machine, a manipulator to direct a target rotation speed of the traveling motor and operation of the work machine, a controller to control the traveling motor and the working motor according to operation of the manipulator, and a temperature sensor to detect temperature of the working motor. The controller maintains or changes a target torque range of the working motor according to a detected temperature of the working motor, and the controller maintains or changes a target rotation speed of the traveling motor so that a calculated output torque value of the working motor falls within the target torque range.

Abstract: A transmission structure of the present invention causes, during a period from a time point when a rotational speed of a drive rotational power reaches a predetermined first/second speed stage shift-up start speed until a first/second speed stage shift-up end time point, one of an input-side clutch mechanism pair and an output-side clutch mechanism pair to be in a double transmitting state, and causes, in the double transmitting state, a first clutch mechanism and a second clutch mechanism of the other one of the input-side clutch mechanism pair and the output-side clutch mechanism pair to be shifted to a disengagement sate and an engagement state, respectively, while having frictional plate slid.

Abstract: The present invention enables generating a desired target travel path intended by a user or the like without the need for various input works for the type, width, and the like of a work machine.

Abstract: An electric vehicle includes a body frame, a seat disposed on the body frame, a wheel attached to the body frame to be driven by an electric motor, a battery to supply electric power to the electric motor via an inverter and an electrical component, a plate member placed inside a covered space with a top being covered and on which the inverter and the electrical component are mounted, and a guide supported by the body frame to drawably guide the plate member from a position inside the covered space to a position outside the covered space.

Abstract: This invention provides a cell population comprising mesenchymal cells capable of forming a cell sheet that can be spontaneously detached from a substrate. In such cell population comprising mesenchymal cells, the proportion of cells positive for CD324 is 70% or more and the proportion of mesenchymal cells positive for CD90 is 90% or more.

Abstract: An air-conditioning apparatus includes a refrigeration circuit, a first shut-off device, a leakage detection device, and a controller configured to perform a refrigerant recovery operation in a case where refrigerant leakage is detected. At the time of the refrigerant recovery operation, the controller performs control to perform a first operation of recovering refrigerant from a load-side heat exchanger into an accumulator and a heat-source-side heat exchanger, and a second operation of moving refrigerant in the heat-source-side heat exchanger to the accumulator. In the first operation, the first shut-off device is closed, a flow passage switching device is brought into a first connection state, and a compressor is driven. The second operation is performed after the first operation, and in the second operation, the connection state of the flow passage switching device is switched to a second connection state in a state where the compressor is being operated.

Abstract: This autonomous travel system is provided with a farm field acquisition unit, a reference auxiliary line creation unit, an adjacent auxiliary line creation unit, and a travel control unit. The farm field acquisition unit acquires information regarding a farm field that includes a work area and a headland area. The reference auxiliary line creation unit creates first reference auxiliary lines within the headland area at positions spaced apart from the farm field peripheral edge on the inner side thereof by a first reference interval. The adjacent auxiliary line creation unit creates, at each of auxiliary line intervals, first adjacent auxiliary lines at positions spaced apart from the first reference auxiliary lines on the inner sides thereof.

Abstract: An air-conditioning apparatus includes a refrigeration circuit, a first shut-off device provided at a pipe connecting a heat-source-side heat exchanger and an expansion device, a refrigerant leak detection device, and a controller. The controller controls a flow switching device to switch a connection state between a first connection state in which a discharge side of a compressor is connected to the heat-source-side heat exchanger, and a second connection state in which a suction side of the compressor is connected to the heat-source-side heat exchanger via an accumulator. When a refrigerant leak is detected, the controller performs a refrigerant retrieval operation and a refrigerant transfer operation.

Abstract: A hydraulic excavator is provided which can suppress the fuel consumption amount and improve the work efficiency by reducing the hydraulic pressure loss generated when a plurality of hydraulic actuators different in load are operated simultaneously.

Abstract: A control system of a lawn mowing vehicle, includes at least one continuously variable transmission drivingly connected to two left and right wheels, a revolution speed detection unit, an acceleration instruction unit, a parking brake instruction sensor, a lawn mower, and a control device. The control device, during the drive of the lawn mower, stops the drive of the lawn mower after the revolution speed of each of the two wheels or the revolution speed of the at least one continuously variable transmission has become zero (0) or within a predetermined range near zero (0), and during stop control of the lawn mower, drives the lawn mower when a target revolution speed, issued by the acceleration instruction unit, of the two wheels or of the at least one continuously variable transmission is not zero (0) and the operation of the parking brake is not instructed.

Abstract: To provide a vehicle including a left continuously variable transmission connected to a left wheel and a right continuously variable transmission connected to a right wheel, at least one operation tool operated to instruct driving of the left wheel and the right wheel, a control device configured to control driving of the left continuously variable transmission and the right continuously variable transmission according to an operation of the at least one operation tool, and a turn operation tool provided on each of the at least one operation tool. If the turn operation tool is operated, the control device controls the left continuously variable transmission and the right continuously variable transmission so that the vehicle is turned to a side of the operated turn operation tool.

Abstract: A lawn mower includes a traveling driver, a mower motor, and at least one controller. At least one controller is configured to control the traveling driver in accordance with an operation of a user getting on the lawn mower, control the traveling driver to cause the lawn mower to travel autonomously, on a basis of information detected on the lawn mower, and control the mower motor. The lawn mower includes a lawn detection device configured to detect a condition of a portion of lawn on a front side in a traveling direction, and a position acquisition device configured to acquire self-position information. The at least one controller controls the traveling driver in such a manner that the lawn mower preferentially travels on a portion of lawn that needs to be mowed.

Abstract: An air-conditioning apparatus includes a refrigeration circuit, a first shut-off device provided at a pipe connecting a heat-source-side heat exchanger and an expansion device, a refrigerant leak detection device, and a controller. The controller controls a flow switching device to switch a connection state between a first connection state in which a discharge side of a compressor is connected to the heat-source-side heat exchanger, and a second connection state in which a suction side of the compressor is connected to the heat-source-side heat exchanger via an accumulator. When a refrigerant leak is detected, the controller performs a refrigerant retrieval operation and a refrigerant transfer operation.