Patents by Inventor Kohei Takubo
Kohei Takubo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9969802Abstract: Provided is a detection method for a malignant tumor cell, including measuring a protein marker expressed on a malignant tumor cell surface. The detection method for a malignant tumor cell includes measuring LR11 on a cell surface in a sample to be tested.Type: GrantFiled: July 15, 2011Date of Patent: May 15, 2018Assignee: SEKISUI MEDICAL CO., LTD.Inventors: Hiroyuki Ebinuma, Kohei Takubo, Isamu Fukamachi, Saishu Yoshida, Hideaki Bujo, Chiaki Nakaseko, Yasushi Saito
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Patent number: 9541550Abstract: To provide a method for assaying soluble LR11 in a biological sample, which method realizes a simple and accurate assay of soluble LR11 present in the sample by immunological means without requiring isolation of soluble LR11 from the biological sample (e.g., a serum sample). The method of the invention for immunologically assaying soluble LR11 present in a biological sample, characterized in that the method includes treating the sample with at least one surfactant selected from among one or more sulfobetaine amphoteric surfactants and one or more amidosulfobetaine amphoteric surfactants.Type: GrantFiled: May 9, 2012Date of Patent: January 10, 2017Assignee: SEKISUI MEDICAL CO., LTD.Inventors: Kohei Takubo, Hiroyuki Ebinuma, Isamu Fukamachi, Hideaki Bujo, Yasushi Saito
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Publication number: 20160311895Abstract: Provided is a general-purpose technique capable of measuring the HbA1c content, which is comparable to the IFCC reference method. An antibody which reacts with a peptide or a protein having an amino acid sequence of VHLTPE (SEQ ID NO: 1) at the N-terminus in which the N-terminal valine is not modified, but does not react with a peptide or a protein in which the N-terminal valine of the relevant polypeptide or protein is modified.Type: ApplicationFiled: July 13, 2016Publication date: October 27, 2016Applicant: SEKISUI MEDICAL CO., LTD.Inventors: Osamu MIYAZAKI, Kohei TAKUBO, Syunsuke KURASHITA
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Patent number: 9341633Abstract: There are provided a pre-treatment technique for a glycated hemoglobin-containing sample, which is a simple and convenient treatment, is free from problems in storage stability and environmental aspects, and is capable of exposing an epitope sufficiently in a short time; and an method for an immunological assay of glycated hemoglobin using this technique. A method for pre-treating a glycated hemoglobin-containing sample for an immunological assay of glycated hemoglobin, the method includes treating a glycated hemoglobin-containing sample with a pre-treatment solution containing (A) guanidine or a salt thereof and (B) a nonionic surfactant and/or a nitrite.Type: GrantFiled: December 10, 2009Date of Patent: May 17, 2016Assignee: SEKISUI MEDICAL CO., LTD.Inventors: Osamu Miyazaki, Syunsuke Kurashita, Kohei Takubo
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Publication number: 20160009794Abstract: Provided is a general-purpose technique capable of measuring the HbA1c content, which is comparable to the IFCC reference method. An antibody which reacts with a peptide or a protein having an amino acid sequence of VHLTPE (SEQ ID NO: 1) at the N-terminus in which the N-terminal valine is not modified, but does not react with a peptide or a protein in which the N-terminal valine of the relevant polypeptide or protein is modified.Type: ApplicationFiled: August 5, 2015Publication date: January 14, 2016Applicant: SEKISUI MEDICAL CO., LTD.Inventors: Osamu MIYAZAKI, Kohei Takubo, Syunsuke Kurashita
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Patent number: 9169320Abstract: Provided is a general-purpose technique capable of measuring the HbA1c content, which is comparable to the IFCC reference method. An antibody which reacts with a peptide or a protein having an amino acid sequence of VHLTPE (SEQ ID NO: 1) at the N-terminus in which the N-terminal valine is not modified, but does not react with a peptide or a protein in which the N-terminal valine of the relevant polypeptide or protein is modified.Type: GrantFiled: December 10, 2009Date of Patent: October 27, 2015Assignee: SEKISUI MEDICAL CO., LTD.Inventors: Osamu Miyazaki, Kohei Takubo, Syunsuke Kurashita
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Patent number: 9097714Abstract: To provide a method and a diagnostic kit for determining the presence of a malignant tumor or the severity thereof, a method for selecting a therapeutic method therefor or evaluating the effect of the therapeutic method, or a method for estimating the risk of recurrence of the malignant tumor or determining the presence or absence of the recurrence. The method for determining the presence of a malignant tumor or the severity thereof, method for selecting a therapeutic method therefor or evaluating the effect of the therapeutic method, or method for estimating the risk of recurrence of the malignant tumor or the presence or absence of the recurrence is characterized by including 1) a step of measuring the concentration and/or quantity of soluble LR11 in a sample originating from a subject and 2) a step of comparing the value measured above with a measurement value of soluble LR11 obtained from a healthy subject group.Type: GrantFiled: December 15, 2010Date of Patent: August 4, 2015Assignee: SEKISUI MEDICAL CO., LTD.Inventors: Hiroyuki Ebinuma, Kohei Takubo, Masanao Matsuo, Isamu Fukamachi, Hideaki Bujo, Chiaki Nakaseko, Yasushi Saito
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Publication number: 20140080158Abstract: To provide a method for assaying soluble LR11 in a biological sample, which method realizes a simple and accurate assay of soluble LR11 present in the sample by immunological means without requiring isolation of soluble LR11 from the biological sample (e.g., a serum sample). The method of the invention for immunologically assaying soluble LR11 present in a biological sample, characterized in that the method includes treating the sample with at least one surfactant selected from among one or more sulfobetaine amphoteric surfactants and one or more amidosulfobetaine amphoteric surfactants.Type: ApplicationFiled: May 9, 2012Publication date: March 20, 2014Applicant: SEKISUI MEDICAL CO., LTD.Inventors: Kohei Takubo, Hiroyuki Ebinuma, Isamu Fukamachi, Hideaki Bujo, Yasushi Saito
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Publication number: 20130115229Abstract: Provided is a detection method for a malignant tumor cell, including measuring a protein marker expressed on a malignant tumor cell surface. The detection method for a malignant tumor cell includes measuring LR11 on a cell surface in a sample to be tested.Type: ApplicationFiled: July 15, 2011Publication date: May 9, 2013Applicant: Sekisui Medical Co., Ltd.Inventors: Hiroyuki Ebinuma, Kohei Takubo, Isamu Fukamachi, Saishu Yoshida, Hideaki Bujo, Chiaki Nakaseko, Yasushi Saito
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Publication number: 20130029363Abstract: To provide a method and a diagnostic kit for determining the presence of a malignant tumor or the severity thereof, a method for selecting a therapeutic method therefor or evaluating the effect of the therapeutic method, or a method for estimating the risk of recurrence of the malignant tumor or determining the presence or absence of the recurrence. The method for determining the presence of a malignant tumor or the severity thereof, method for selecting a therapeutic method therefor or evaluating the effect of the therapeutic method, or method for estimating the risk of recurrence of the malignant tumor or the presence or absence of the recurrence is characterized by including 1) a step of measuring the concentration and/or quantity of soluble LR11 in a sample originating from a subject and 2) a step of comparing the value measured above with a measurement value of soluble LR11 obtained from a healthy subject group.Type: ApplicationFiled: December 15, 2010Publication date: January 31, 2013Applicant: Sekisui Medical Co., Ltd.Inventors: Hiroyuki Ebinuma, Kohei Takubo, Masanao Matsuo, Isamu Fukamachi, Hideaki Bujo, Chiaki Nakaseko, Yasushi Saito
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Publication number: 20110318765Abstract: There are provided a pre-treatment technique for a glycated hemoglobin-containing sample, which is a simple and convenient treatment, is free from problems in storage stability and environmental aspects, and is capable of exposing an epitope sufficiently in a short time; and an method for an immunological assay of glycated hemoglobin using this technique. A method for pre-treating a glycated hemoglobin-containing sample for an immunological assay of glycated hemoglobin, the method includes treating a glycated hemoglobin-containing sample with a pre-treatment solution containing (A) guanidine or a salt thereof and (B) a nonionic surfactant and/or a nitrite.Type: ApplicationFiled: December 10, 2009Publication date: December 29, 2011Applicant: Sekisui Medical Co., Ltd.Inventors: Osamu Miyazaki, Syunsuke Kurashita, Kohei Takubo
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Publication number: 20110311989Abstract: Provided is a general-purpose technique capable of measuring the HbA1c content, which is comparable to the IFCC reference method. An antibody which reacts with a peptide or a protein having an amino acid sequence of VHLTPE (SEQ ID NO: 1) at the N-terminus in which the N-terminal valine is not modified, but does not react with a peptide or a protein in which the N-terminal valine of the relevant polypeptide or protein is modified.Type: ApplicationFiled: December 10, 2009Publication date: December 22, 2011Applicant: SEKISUI MEDICAL CO., LTD.Inventors: Osamu Miyazaki, Kohei Takubo, Syunsuke Kurashita