Abstract: Provided are a method of simply detecting Alzheimer's disease (AD) and a method of simply stratifying AD pathological phases, and a reagent that can be used for the methods, based on the fact that measurement of a protein contained in extracellular vesicles enables detection of Alzheimer's disease and stratification of AD pathological phases.

Abstract: There are provided a method for detecting amyloid-? bound to a brain-neuronal-cell-derived exosome in blood, the method including: a step of binding amyloid-? bound to the brain-neuronal-cell-derived exosome in blood to an amyloid-?-specific binding substance that specifically binds to amyloid-?, labeled with a nucleic acid fragment; and a step of detecting the amyloid-?-specific binding substance, and a method for evaluating an accumulation level of amyloid-? in a brain, the method including: a step of detecting amyloid-? bound to the brain-neuronal-cell-derived exosome in blood; and a step of evaluating an accumulation level of amyloid-? in a brain based on the detected amount of the amyloid-?.

Abstract: The purpose of the present invention is to provide an agent for preventing or ameliorating Alzheimer's disease, said agent being able to effectively suppress the accumulation of amyloid ? proteins using a safe material, which has been used in foods for many years, and improve spontaneous alternation behavior change ratio. Ceramides (in particular, a glucosylceramide originating in Amorphophallus konjac) can effectively suppress the accumulation of amyloid ? proteins and thus enables the prevention or amelioration of Alzheimer's disease.

Abstract: The purpose of the present invention is to provide an agent for preventing or ameliorating Alzheimer's disease, said agent being able to effectively suppress the accumulation of amyloid ? proteins using a safe material, which has been used in foods for many years, and improve spontaneous alternation behavior change ratio. Ceramides (in particular, a glucosylceramide originating in Amorphophallus konjac) can effectively suppress the accumulation of amyloid ? proteins and thus enables the prevention or amelioration of Alzheimers disease.

Abstract: The purpose of the present invention is to provide an agent for promoting exosome production with which exosome production can be easily promoted.

Abstract: The purpose of the present invention is to provide an agent for preventing or ameliorating Alzheimer's disease, said agent being able to effectively suppress the accumulation of amyloid ? proteins using a safe material, which has been used in foods for many years, and improve spontaneous alternation behavior change ratio. Ceramides (in particular, a glucosylceramide originating in Amorphophallus konjac) can effectively suppress the accumulation of amyloid ? proteins and thus enables the prevention or amelioration of Alzheimers disease.

Abstract: The present invention is directed to providing a medicament for treating or preventing a condition, disorder or disease associated with amyloid ?. Provided is a method for screening a medicament for treating or preventing a disease associated with amyloid ?, the method comprising: A) subjecting at least one of elements selected from the group consisting of 1) exosome; 2) neutral sphingomyelinase 2 (N-SMase2); and 3) sphingomyelin synthetic enzyme 2 (SMS2), and a candidate of the medicament in a condition in which they can interact with each other; and B) examining an influence by the candidate of the medicament to the element, wherein at least one of the elements is used as an index for determining as to whether or not the candidate is the medicament.

Abstract: An ink composition for sensing carbon dioxide gas contains a pH indicator formed using a combination of two or more types of pH indicator components, binder, and solvent and allows easy visual observation of color changes of an indicating portion caused by the concentration of carbon dioxide gas. When the ink composition is applied to a carbon dioxide indicator and package, a pinhole and poor seal of a carbon-dioxide-ambient package are easily found.

Abstract: An ink composition for sensing carbon dioxide gas contains a pH indicator formed using a combination of two or more types of pH indicator components, binder, and solvent and allows easy visual observation of color changes of an indicating portion caused by the concentration of carbon dioxide gas. When the ink composition is applied to a carbon dioxide indicator and package, a pinhole and poor seal of a carbon-dioxide-ambient package are easily found.