Patents by Inventor Kohji Ohki

Kohji Ohki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210401928
    Abstract: [Problem] The purpose of the present invention is to provide a novel technique associated with anti-obesity improvement. [Solution] The present invention relates to an anti-obesity agent comprising lactononadecapeptide (LNDP, Asn-Ile-Pro-Pro-Leu-Thr-Gln-Thr-Pro-Val-Val-Val-Pro-Pro-Phe-Leu-Gln-Pro-Glu) or a salt thereof. The present invention also relates to a pollakiuria improving agent and an autonomic nerve activity regulator each comprising LNDP.
    Type: Application
    Filed: October 17, 2019
    Publication date: December 30, 2021
    Applicant: ASAHI GROUP HOLDINGS, LTD.
    Inventors: Kohji OHKI, Koki SATO, Kazuhito OHSAWA
  • Patent number: 10583165
    Abstract: There is provided a method comprising orally administering a composition before and/or during exercise. The composition contains a casein hydrolysate containing a free amino acid and a peptide, or a mixture of the free amino acid and the peptide. The casein hydrolysate is produced by hydrolyzing an animal milk casein, and has an average chain length of 2.1 or less in terms of the number of amino acid residues. There is further provided an oral composition for use in the method. The oral composition contains, as an active ingredient, a casein hydrolysate containing a free amino acid and a peptide, or a mixture of the free amino acid and the peptide. The casein hydrolysate is produced by hydrolyzing an animal milk casein, and has an average chain length of 2.1 or less in terms of the number of amino acid residues. There is still further provided the use of the oral composition for inhibiting increase in heart rate during exercise.
    Type: Grant
    Filed: May 13, 2016
    Date of Patent: March 10, 2020
    Assignee: ASAHI CALPIS WELLNESS CO., LTD.
    Inventors: Hidetoshi Miyazaki, Kohji Ohki
  • Publication number: 20180085419
    Abstract: There is provided a method comprising orally administering a composition before and/or during exercise. The composition contains a casein hydrolysate containing a free amino acid and a peptide, or a mixture of the free amino acid and the peptide. The casein hydrolysate is produced by hydrolyzing an animal milk casein, and has an average chain length of 2.1 or less in terms of the number of amino acid residues. There is further provided an oral composition for use in the method. The oral composition contains, as an active ingredient, a casein hydrolysate containing a free amino acid and a peptide, or a mixture of the free amino acid and the peptide. The casein hydrolysate is produced by hydrolyzing an animal milk casein, and has an average chain length of 2.1 or less in terms of the number of amino acid residues. There is still further provided the use of the oral composition for inhibiting increase in heart rate during exercise.
    Type: Application
    Filed: May 13, 2016
    Publication date: March 29, 2018
    Applicant: ASAHI CALPIS WELLNESS CO., LTD.
    Inventors: Hidetoshi MIYAZAKI, Kohji OHKI
  • Patent number: 9523109
    Abstract: The invention provides a method for preparing a peptide for improving brain function, comprising hydrolyzing milk casein with an enzymatic catalyst comprising a protease to produce a hydrolysate comprising: (i) a peptide consisting of the amino acid sequence shown in SEQ ID NO: 1 or a variant thereof; (ii) a peptide consisting of the amino acid sequence shown in SEQ ID NO: 2 or a variant thereof; or (iii) a mixture of the peptides of (i) and (ii), wherein the production yield of each of the peptides is 2% or more, or the total production yield of the mixture is 10% or more. The invention also provides a food or drink or a pharmaceutical composition containing the hydrolysate.
    Type: Grant
    Filed: June 13, 2012
    Date of Patent: December 20, 2016
    Assignee: CALPIS CO., LTD.
    Inventors: Naoto Uchida, Hiroaki Goto, Kazuhito Ohsawa, Kohji Ohki
  • Publication number: 20150307549
    Abstract: Provided is an agent having at least one of an improving effect on vascular endothelial functions and an inhibitory effect on vascular intimal thickening, as well as a prophylactic of arteriosclerosis, which have excellent safety, improve functions associated with the vascular endothelium, have effects of preventing various diseases associated with vascular endothelial functions and of inhibiting vascular intimal thickening, and may be expected to provide prophylactic effect on arteriosclerosis. The agents of the present invention contain, as an active component: (a) Xaa-Pro-Pro, (b) a hydrolysate of animal milk casein containing Xaa-Pro-Pro, or a concentrate thereof, or (c) a fermentation product containing Ile-Pro-Pro and/or Val-Pro-Pro obtained by fermenting a starting material containing milk protein with a bacterial strain of the species Lactobacillus helveticus.
    Type: Application
    Filed: July 8, 2015
    Publication date: October 29, 2015
    Applicant: CALPIS Co., LTD
    Inventors: Tatsuhiko HIROTA, Teppei NAKAMURA, Kohji OHKI, Akihiro MASUYAMA, Toshiaki TAKANO, Toshikazu YOSHIKAWA, Yuji NAITO, Hiroshi ICHIKAWA, Satomi AKAGIRI
  • Patent number: 9067972
    Abstract: The present invention provides a peptide and a composition which are suitable for oral ingestion, and which have a skin aging-inhibiting activity, a collagen-production promoting activity, an epidermal turnover promoting activity, and a cutaneous cell-proliferating effect. The present invention also provides a medicament and a functional food which have a skin aging-inhibiting activity, a collagen-production promoting activity, and a cutaneous cell-proliferation promoting activity. The present invention provides a composition including at least one peptide of Asn-lle-Pro-Pro-Leu, lle-Pro-Pro-Leu, lle-Pro-Pro, Pro-Val-Val-Val-Pro-Pro, Val-Pro-Pro-Phe, Val-Pro-Pro, Phe-Pro-Pro-Gln, and Leu-Pro-Pro-Thr.
    Type: Grant
    Filed: September 2, 2010
    Date of Patent: June 30, 2015
    Assignee: CALPIS CO., LTD.
    Inventors: Kazuhito Ohsawa, Naoto Uchida, Hidehiko Baba, Michio Hatori, Kohji Ohki
  • Patent number: 8916524
    Abstract: The present invention provides a composition which may be ingested orally in a small dose for the purpose of improving brain function, and a method for improving brain function. The present invention is a composition for improving brain function, comprising, as an active ingredient, X-Pro-Pro-Y or a salt thereof, wherein X represent Val, Ile or Asn-Ile and Y represent Phe or Leu.
    Type: Grant
    Filed: September 15, 2011
    Date of Patent: December 23, 2014
    Assignee: Calpis Co., Ltd.
    Inventors: Kazuhito Ohsawa, Naoto Uchida, Kohji Ohki
  • Patent number: 8895512
    Abstract: The present invention provides a composition which may be ingested orally in a small dose for the purpose of improving brain function, and a method for improving brain function. The present invention is a composition for improving brain function, comprising, as an active ingredient, Phe-Pro.
    Type: Grant
    Filed: September 15, 2011
    Date of Patent: November 25, 2014
    Assignee: Calpis Co., Ltd.
    Inventors: Kazuhito Ohsawa, Naoto Uchida, Kohji Ohki
  • Publication number: 20140342991
    Abstract: The present invention provides a composition which may be ingested orally in a small dose for the purpose of improving brain function, and a method for improving brain function. The present invention is a composition for improving brain function, comprising, as an active ingredient, X-Pro-Pro-Y or a salt thereof, wherein X represent Val, Ile or Asn-Ile and Y represent Phe or Leu.
    Type: Application
    Filed: July 31, 2014
    Publication date: November 20, 2014
    Inventors: Kazuhito OHSAWA, Naoto UCHIDA, Kohji OHKI
  • Patent number: 8673854
    Abstract: The present invention provides an agent having a suppressive action against the thickening of the heart wall, a prophylactic agent for heart failure containing the above described agent, and functional foods expected to have a prophylactic effect for heart failure. The agent for suppressing heart wall thickening comprises Xaa Pro Pro as an active ingredient.
    Type: Grant
    Filed: November 10, 2011
    Date of Patent: March 18, 2014
    Assignee: Calpis Co., Ltd.
    Inventors: Tatsuhiko Hirota, Kohji Ohki, Teppei Nakamura, Toshiaki Takano
  • Patent number: 8569241
    Abstract: Provided are a composition for improving the brain function, which can be orally taken at a low dose, and a method therefor. The composition for improving the brain function contains, as the active ingredient, X-Pro-Pro-Leu-Thr-Gln-Thr-Pro-Val-Val-Val-Pro-Pro-Phe-Leu-Gln-Pro-Glu-Y (wherein X is nil or represents Ile or Asn-Ile; and Y is nil or represents Val-Met), X-Val-Val-Val-Pro-Pro-Phe-Leu-Gln-Pro-Glu-Y (wherein X is abscent or represents Thr-Gln-Thr-Pro, Pro-Leu-Thr-Gln-Thr-Pro, Leu-Thr-Gln-Thr-Pro or Pro; and Y is abscent or represents Val-Met), or a salt of the same. The method for improving the brain function comprises administering said peptide or a salt of the same.
    Type: Grant
    Filed: June 25, 2012
    Date of Patent: October 29, 2013
    Assignee: Calpis Co., Ltd.
    Inventors: Kazuhito Ohsawa, Naoto Uchida, Kohji Ohki, Hiroaki Goto
  • Patent number: 8367614
    Abstract: There is provided a rheumatoid arthritis inhibitor for oral intake that has an inhibitory effect on rheumatoid arthritis and is excellent in safety. The rheumatoid arthritis inhibitor for oral intake of the present invention contains, as an active component, a casein hydrolysate containing free amino acids and peptides obtained by hydrolyzing animal milk casein to have an average chain length of not longer than 2.1 in terms of the number of amino acid residues, or a mixture of free amino acids and peptides contained in the hydrolysate.
    Type: Grant
    Filed: June 15, 2011
    Date of Patent: February 5, 2013
    Assignee: Calpis Co., Ltd
    Inventors: Michio Hatori, Kohji Ohki, Naomi Hashimura, Tatsuhiko Hirota, Kazuhito Ohsawa
  • Patent number: 8344101
    Abstract: The present invention provides a composition which may be ingested orally in a small dose for the purpose of improving brain function, and a method for improving brain function. The present invention is a composition for improving brain function, the composition comprising, as an active ingredient, X-Met-His-Gln-Pro-His-Gln-Pro-Leu-Pro-Pro-Thr-Val-Met-Phe-Pro-Pro-Gln-Ser-Val-Leu (SEQ ID NO: 6) or a salt thereof, wherein X is absent or represents Ser-Trp or Leu-Gln-Ser-Trp (SEQ ID NO: 7).
    Type: Grant
    Filed: September 24, 2010
    Date of Patent: January 1, 2013
    Assignee: Calpis Co., Ltd.
    Inventors: Kazuhito Ohsawa, Naoto Uchida, Kohji Ohki
  • Patent number: 8343925
    Abstract: The present invention provides a composition which may be ingested orally in a small dose for the purpose of improving brain function, and a method for improving brain function. The present invention is a composition for improving brain function, the composition comprising, as an active ingredient, Xaa-Pro-Pro (wherein Xaa represents Ile, Leu or Ser).
    Type: Grant
    Filed: September 24, 2010
    Date of Patent: January 1, 2013
    Assignee: Calpis Co., Ltd.
    Inventors: Kazuhito Ohsawa, Naoto Uchida, Kohji Ohki
  • Patent number: 8343924
    Abstract: The present invention provides a composition which may be ingested orally in a small dose for the purpose of improving brain function, and a method for improving brain function. The present invention is a composition for improving brain function, comprising, as an active ingredient, X-Val-Arg-Gly-Pro-Phe-Pro-Ile-Ile-Val (SEQ ID NO: 5), wherein X is absent or represents Pro.
    Type: Grant
    Filed: September 24, 2010
    Date of Patent: January 1, 2013
    Assignee: Calpis Co., Ltd.
    Inventors: Kazuhito Ohsawa, Naoto Uchida, Kohji Ohki
  • Publication number: 20120329722
    Abstract: The invention provides a method for preparing a peptide for improving brain function, comprising hydrolyzing milk casein with an enzymatic catalyst comprising a protease to produce a hydrolysate comprising: (i) a peptide consisting of the amino acid sequence shown in SEQ ID NO: 1 or a variant thereof; (ii) a peptide consisting of the amino acid sequence shown in SEQ ID NO: 2 or a variant thereof; or (iii) a mixture of the peptides of (i) and (ii), wherein the production yield of each of the peptides is 2% or more, or the total production yield of the mixture is 10% or more. The invention also provides a food or drink or a pharmaceutical composition containing the hydrolysate.
    Type: Application
    Filed: June 13, 2012
    Publication date: December 27, 2012
    Inventors: Naoto Uchida, Hiroaki Goto, Kazuhito Ohsawa, Kohji Ohki
  • Publication number: 20120328735
    Abstract: The present invention relates to a method for preparing a casein-derived peptide by fermentation of a lactic acid bacterium. The present invention also relates to a composition containing the peptide, and a method for preparing a functional food.
    Type: Application
    Filed: June 13, 2012
    Publication date: December 27, 2012
    Inventors: Naoto Uchida, Hiroaki Goto, Kazuhito Ohsawa, Kohji Ohki
  • Publication number: 20120277160
    Abstract: Provided are a composition for improving the brain function, which can be orally taken at a low dose, and a method therefor. The composition for improving the brain function contains, as the active ingredient, X-Pro-Pro-Leu-Thr-Gln-Thr-Pro-Val-Val-Val-Pro-Pro-Phe-Leu-Gln-Pro-Glu-Y (wherein X is nil or represents Ile or Asn-Ile; and Y is nil or represents Val-Met), X-Val-Val-Val-Pro-Pro-Phe-Leu-Gln-Pro-Glu-Y (wherein X is abscent or represents Thr-Gln-Thr-Pro, Pro-Leu-Thr-Gln-Thr-Pro, Leu-Thr-Gln-Thr-Pro or Pro; and Y is abscent or represents Val-Met), or a salt of the same. The method for improving the brain function comprises administering said peptide or a salt of the same.
    Type: Application
    Filed: June 25, 2012
    Publication date: November 1, 2012
    Inventors: Kazuhito OHSAWA, Naoto UCHIDA, Kohji OHKI, Hiroaki GOTO
  • Publication number: 20120083451
    Abstract: The present invention provides a composition which may be ingested orally in a small dose for the purpose of improving brain function, and a method for improving brain function. The present invention is a composition for improving brain function, comprising, as an active ingredient, X-Pro-Pro-Y or a salt thereof, wherein X represent Val, Ile or Asn-Ile and Y represent Phe or Leu.
    Type: Application
    Filed: September 15, 2011
    Publication date: April 5, 2012
    Inventors: Kazuhito OHSAWA, Naoto Uchida, Kohji Ohki
  • Publication number: 20120077735
    Abstract: The present invention provides an agent having a suppressive action against kidney glomerular disease and renal arteriosclerosis, a prophylactic agent for renal failure containing the above described agent, and functional foods expected to have a prophylactic effect for renal failure. The agent for preventing kidney glomerular disease and renal arteriosclerosis comprises Xaa Pro Pro as an active ingredient.
    Type: Application
    Filed: November 10, 2011
    Publication date: March 29, 2012
    Inventors: Tatsuhiko Hirota, Kohji Ohki, Teppei Nakamura, Toshiaki Takano