Patents by Inventor Koichi Fujimoto

Koichi Fujimoto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6052945
    Abstract: A strong metal plate having flexibility includes a flat portion, a plurality of first protuberances projecting from the flat portion in one direction of the thickness direction of the flat portion and a plurality of second protuberances projecting from the flat portion in the other direction of the thickness.
    Type: Grant
    Filed: March 7, 1997
    Date of Patent: April 25, 2000
    Assignee: Aisin Seiki Kabushiki Kaisha
    Inventors: Sukekazu Asada, Yukio Isomura, Kazuhide Itagaki, Hiroyuki Yamamoto, Koichi Fujimoto
  • Patent number: 5977365
    Abstract: Compounds of formula (I): ##STR1## [wherein: X represents an unsubstituted or substituted indolyl, indolinyl, azaindolyl, azaindolinyl, imidazopyridyl or imidazopyrinidinyl group; Y represents an oxygen or sulfur atom; Z represents a 2,4-dioxo-thiazolidin-5-ylidenylmethyl, 2,4-dioxothiazolidin-5-ylmethyl, 2,4-dioxooxazolidin-5-ylmethyl, 3,5-dioxo-oxadiazolidin-2-ylmethyl or N-hydroxyureidom ethyl group; R represents a hydrogen atom, an alkyl group, an alkoxy group, a halogen atom, a hydroxy group, a nitro group, an aralkyl group or a unsubstituted or substituted amino group; and m is an inzeger of from 1 to 5] have hypoglycemic and anti-diabetic activities.
    Type: Grant
    Filed: July 7, 1998
    Date of Patent: November 2, 1999
    Assignee: Sankyo Company, Limited
    Inventors: Takashi Fujita, Takao Yoshioka, Toshihiko Fujiwara, Minoru Oguchi, Hiroaki Yanagisawa, Hiroyoshi Horikoshi, Kunio Wada, Koichi Fujimoto
  • Patent number: 5972959
    Abstract: Compounds of formula (I): ##STR1## wherein: R.sup.1 is hydrogen or alkyl; R.sup.2 is alkylene; R.sup.3 is hydrogen, alkyl, alkoxy, alkylthio, halogen, nitro group, amino group, monoalkylamino, dialkylamino, aryl, or aralkyl; X is aryl, or aromatic heterocyclic; Y is oxygen, sulfur or a group of formula >N--R.sup.4, in which R.sup.4 is hydrogen, alkyl or acyl; and Z is a group of formula (Za), (Zb), (Zc) or (Zd): ##STR2## and salts thereof can be used to treat or prevent are included those arising from hyperlipidemia, hyperglycemia, obesity, impaired glucose tolerance (IGT), insulin resistant non-IGT (NGT), non-diagnostic glucose tolerance, insulin resistance, diabetic complications, fatty liver, polycystic ovary syndrome (PCOS) and gestational diabetes mellitus (GDM); in addition the compounds of the present invention have aldose reductase inhibitory activity.
    Type: Grant
    Filed: April 21, 1998
    Date of Patent: October 26, 1999
    Assignee: Sankyo Company, Limited
    Inventors: Hiroaki Yanagisawa, Takashi Fujita, Koichi Fujimoto, Takao Yoshioka, Kunio Wada, Minoru Oguchi, Toshihiko Fujiwara, Hiroyoshi Horikoshi
  • Patent number: 5962470
    Abstract: Compounds of formula (I): ##STR1## ?wherein: X represents an unsubstituted or substituted indolyl, indolinyl, azaindolyl, azaindolinyl, imidazopyridyl or imidazopyrimidinyl group; Y represents an oxygen or sulfur atom; Z represents a 2,4-dioxo-thiazolidin-5-ylidenylmethyl, 2,4-dioxothiazolidin-5-ylmethyl, 2,4-dioxooxazolidin-5-ylmethyl, 3,5-dioxo-oxadiazolidin-2-ylmethyl or N-hydroxyureidomethyl group; R represents a hydrogen atom, an alkyl group, an alkoxy group, a halogen atom, a hydroxy group, a nitro group, an aralkyl group or a unsubstituted or substituted amino group; and m is an integer of from 1 to 5! have hypoglycemic and anti-diabetic activities.
    Type: Grant
    Filed: December 30, 1997
    Date of Patent: October 5, 1999
    Assignee: Sankyo Company, Limited
    Inventors: Takashi Fujita, Takao Yoshioka, Toshihiko Fujiwara, Minoru Oguchi, Hiroaki Yanagisawa, Hiroyoshi Horikoshi, Kunio Wada, Koichi Fujimoto
  • Patent number: 5886014
    Abstract: Compounds of formula (I): ##STR1## ?wherein: X represents an optionally substituted benzimidazole group; Y represents an oxygen or sulfur atom; Z represents a 2,4-dioxothiazolidin-5-ylidenylmethyl, 2,4-dioxothiazolidin-5-ylmethyl, 2,4-dioxooxazolidin-5-ylmethyl, 3,5-dioxooxadiazolidin-2-ylmethyl or N-hydroxyureidomethlyl group; R represents hydrogen, alkyl, alkoxy, halogen, hydroxy, nitro, amino or aralkyl; and m is an integer from 1 to 5!; have valuable activity for the treatment and/or prophylaxis of a variety of disorders, including one or more of: hyperlipemia, hyperglycemia, obesity, impaired glucose tolerance (IGT), insulin resistance and diabetic complications.
    Type: Grant
    Filed: May 31, 1996
    Date of Patent: March 23, 1999
    Assignee: Sankyo Company, Limited
    Inventors: Takashi Fujita, Kunio Wada, Minoru Oguchi, Hiroaki Yanagisawa, Koichi Fujimoto, Toshihiko Fujiwara, Hiroyoshi Horikoshi, Takao Yoshioka
  • Patent number: 5843983
    Abstract: Compounds of formula (I): ##STR1## wherein: R.sup.1 represents a saturated heterocyclic group attached to the bond or group represented by A through a ring carbon atom; R.sup.2a, R.sup.2b, R.sup.2c, R.sup.3a, R.sup.3b, R.sup.3c and R.sup.3d are hydrogen or various other groups or atoms; and A represents a single bond or an alkylene group having from 1 to 6 carbon atoms are serotonin 2 receptor antagonists and have the ability to inhibit the activity of squalene synthase. They can not only prevent and inhibit the development and progression of arteriosclerosis but can also inhibit thrombosis in arteriosclerotic lesions and can improve hemodynamics.
    Type: Grant
    Filed: February 10, 1997
    Date of Patent: December 1, 1998
    Assignee: Sankyo Company, Limited
    Inventors: Koichi Fujimoto, Naoki Tanaka, Fumitoshi Asai, Taketoshi Ogawa, Teiichiro Koga, Tatsuo Tanimoto, Yoshio Tsujita, Hiroyuki Koike
  • Patent number: 5834501
    Abstract: Compounds of formula (I): ##STR1## wherein: X represents an unsubstituted or substituted indolyl, indolinyl, azaindolyl, azaindolinyl, imidazopyridyl or imidazopyrimidinyl group; Y represents an oxygen or sulfur atom; Z represents a 2,4-dioxo-thiazolidin-5-ylidenylmethyl, 2,4-dioxothiazolidin-5-ylmethyl, 2,4-dioxooxazolidin-5-ylmethyl, 3,5-dioxo-oxadiazolidin-2-ylmethyl or N-hydroxyureidom ethyl group; R represents a hydrogen atom, an alkyl group, an alkoxy group, a halogen atom, a hydroxy group, a nitro group, an aralkyl group or a unsubstituted or substituted amino group; and m is an integer of from 1 to 5 have hypoglycemic and anti-diabetic activities.
    Type: Grant
    Filed: September 13, 1996
    Date of Patent: November 10, 1998
    Assignee: Sankyo Company, Limited
    Inventors: Takashi Fujita, Takao Yoshioka, Toshihiko Fujiwara, Minoru Oguchi, Hiroaki Yanagisawa, Hiroyoshi Horikoshi, Kunio Wada, Koichi Fujimoto
  • Patent number: 5826376
    Abstract: A window regulator for a vehicle has a lift arm pivotally mounted on a door panel of a vehicle. A gear plate including teeth on the periphery thereof is connected to one end of the lift arm. A driving device engages with the teeth and moves the gear plate. A movable rail is connected to a window glass, the movable rail engaging with the other end of the lift arm. Holes are disposed in one end of the lift arm and convex portions are disposed in said gear plate, the convex portions being inserted into said holes and pressed into a flat shape.
    Type: Grant
    Filed: October 23, 1996
    Date of Patent: October 27, 1998
    Assignee: Aisin Seiki Kabushiki Kaisha
    Inventors: Hiroyuki Yamamoto, Koichi Fujimoto, Yukio Isomura
  • Patent number: 5780490
    Abstract: Compounds of formula (I): ##STR1## wherein: R.sup.1 is hydrogen or alkyl; R.sup.2 is alkylene; R.sup.3 is hydrogen, alkyl, alkoxy, alkylthio, halogen, nitro group, amino group, monoalkylamino, dialkylamino, aryl, or aralkyl; X is aryl, or aromatic heterocyclic; Y is oxygen, sulfur or a group of formula >N--R.sup.4, in which R.sup.4 is hydrogen, alkyl or acyl; and Z is a group of formula (Za), (Zb), (Zc) or (Zd): ##STR2## and salts thereof can be used to treat or prevent are included those arising from hyperlipidemia, hyperglycemia, obesity, impaired glucose tolerance (IGT), insulin resistant non-IGT (NGT), non-diagnostic glucose tolerance, insulin resistance, diabetic complications, fatty liver, polycystic ovary syndrome (PCOS) and gestational diabetes mellitus (GDM); in addition the compounds of the present invention have aldose reductase inhibitory activity.
    Type: Grant
    Filed: June 18, 1997
    Date of Patent: July 14, 1998
    Assignee: Sankyo Company, Limited
    Inventors: Hiroaki Yanagisawa, Takashi Fujita, Koichi Fujimoto, Takao Yoshioka, Kunio Wada, Minoru Oguchi, Toshihiko Fujiwara, Hiroyoshi Horikoshi
  • Patent number: 5739345
    Abstract: Compounds of formula (I): ##STR1## ?wherein: X represents an unsubstituted or substituted indolyl, indolinyl, azaindolyl, azaindolinyl, imidazopyridyl or imidazopyrimidinyl group; Y represents an oxygen or sulfur atom; Z represents a 2,4-dioxo-thiazolidin-5-ylidenylmethyl, 2,4-dioxothiazolidin-5-ylmethyl, 2,4-dioxooxazolidin-5-ylmethyl, 3,5-dioxooxadiazolidin-2-ylmethyl or N-hydroxyureidomethyl group; R represents a hydrogen atom, an alkyl group, an alkoxy group, a halogen atom, a hydroxy group, a nitro group, an aralkyl group or a unsubstituted or substituted amino group; and m is an integer of from 1 to 5! have hypoglycemic and anti-diabetic activities. Disclosed also are intermediate compounds for the preparation of compounds of formula I.
    Type: Grant
    Filed: November 8, 1996
    Date of Patent: April 14, 1998
    Assignee: Sankyo Company, Limited
    Inventors: Takashi Fujita, Takao Yoshioka, Toshihiko Fujiwara, Minoru Oguchi, Hiroaki Yanagisawa, Hiroyoshi Horikoshi, Kunio Wada, Koichi Fujimoto
  • Patent number: 5703096
    Abstract: Compounds of formula (I): ##STR1## wherein: R.sup.1 is hydrogen or alkyl; R.sup.2 is alkylene; R.sup.3 is hydrogen, alkyl, alkoxy, alkylthio, halogen, nitro group, amino group, monoalkylamino, dialkylamino, aryl, or aralkyl; X is aryl, or aromatic heterocyclic; Y is oxygen, sulfur or a group of formula >N-R.sup.4, in which R.sup.4 is hydrogen, alkyl or acyl; and Z is a group of formula (Za), (Zb), (Zc) or (Zd): ##STR2## and salts thereof can be used to treat or prevent are included those arising from hyperlipidemia, hyperglycemia, obesity, impaired glucose tolerance (IGT), insulin resistant non-IGT (NGT), non-diagnostic glucose tolerance, insulin resistance, diabetic complications, fatty liver, polycystic ovary syndrome (PCOS) and gestational diabetes mellitus (GDM); in addition the compounds of the present invention have aldose reductase inhibitory activity.
    Type: Grant
    Filed: October 5, 1995
    Date of Patent: December 30, 1997
    Assignee: Sankyo Company, Limited
    Inventors: Hiroaki Yanagisawa, Takashi Fujita, Koichi Fujimoto, Takao Yoshioka, Kunio Wada, Minoru Oguchi, Toshihiko Fujiwara, Hiroyoshi Horikoshi
  • Patent number: 5688823
    Abstract: Compounds of formula (I): ##STR1## Z is a group of formula (iii), (iv),: ##STR2## and salts, esters and solvates thereof and pro-drugs therefor are useful for the treatment and/or prophylaxis of a variety of disorders, including one or more of: hyperlipemia, hyperglycemia, obesity, glucose tolerance insufficiency, insulin resistance and diabetic complications.
    Type: Grant
    Filed: February 21, 1996
    Date of Patent: November 18, 1997
    Assignee: Sankyo Company, Limited
    Inventors: Takashi Fujita, Koichi Fujimoto, Takao Yoshioka, Hiroaki Yanagisawa, Toshihiko Fujiwara, Hiroyoshi Horikoshi, Minoru Oguchi, Kunio Wada
  • Patent number: 5624935
    Abstract: Compounds of formula (I): ##STR1## [wherein: X represents an unsubstituted or substituted indolyl, indolinyl, azaindolyl, azaindolinyl, imidazopyridyl or imidazopyrimidinyl group; Y represents an oxygen or sulfur atom; Z represents a 2,4-dioxothiazolidin-5-ylidenylmethyl, 2,4-dioxothiazolidin-5-ylmethyl, 2,4-dioxooxazolidin-5-ylmethyl, 3,5-dioxooxadiazolidin-2-ylmethyl or N-hydroxyureidomethyl group; R represents a hydrogen atom, an alkyl group, an alkoxy group, a halogen atom, a hydroxy group, a nitro group, an aralkyl group or a unsubstituted or substituted amino group; and m is an integer of from 1 to 5] have hypoglycemic and anti-diabetic activities.
    Type: Grant
    Filed: April 11, 1995
    Date of Patent: April 29, 1997
    Assignee: Sankyo Company, Limited
    Inventors: Takashi Fujita, Takao Yoshioka, Toshihiko Fujiwara, Minoru Oguchi, Hiroaki Yanagisawa, Hiroyoshi Horikoshi, Kunio Wada, Koichi Fujimoto
  • Patent number: 5616599
    Abstract: Compounds of the following formula (I) or the formula (I).sub.p : ##STR1## wherein R.sup.1 is alkyl or alkenyl; R.sup.2 and R.sup.3 are hydrogen, alkyl, alkenyl, cycloalkyl, aralkyl, aryl, or aryl fused to cycloalkyl; R.sup.4 is hydrogen, alkyl, alkanoyl, alkenoyl, arylcarbonyl, alkoxycarbonyl, tetrahydropyranyl, tetrahydrothiopyranyl, tetrahydrothienyl, tetrahydrofuryl, a group of formula --SiR.sup.a R.sup.b R.sup.c, in which R.sup.a, R.sup.b and R.sup.c are alkyl or aryl, alkoxymethyl, (alkoxyalkoxy)methyl, haloalkoxymethyl, aralkyl, aryl or alkanoyloxymethoxycarbonyl; R.sup.5 is carboxy or --CONR.sup.8 R.sup.9, wherein R.sup.8 and R.sup.9 hydrogens or alkyl, or R.sup.8 and R.sup.9 together form alkylene; R.sup.6 is hydrogen, alkyl, alkoxy or halogen; R.sup.7 is carboxy or tetrazol-5-yl; R.sub.p.sup.1 is hydrogen, alkyl, cycloalkyl or alkanoyl; R.sub.p.sup.2 is a single bond, alkylene or alkylidene; R.sub.p.sup.3 and R.sub.p.sup.4 are each hydrogen or alkyl; R.sub.p.sup.6 is carboxy or tetrazol-5-yl; and X.
    Type: Grant
    Filed: January 26, 1995
    Date of Patent: April 1, 1997
    Assignee: Sankyo Company, Limited
    Inventors: Hiroaki Yanagisawa, Koichi Fujimoto, Yoshiya Amemiya, Yasuo Shimoji, Takuro Kanazaki, Hiroyuki Koike, Toshio Sada
  • Patent number: 5578620
    Abstract: Compounds of formula (I): ##STR1## and salts, esters and solyates thereof and pro-drugs therefor are useful for the treatment and/or prophylaxis of a variety of disorders, including one or more of: hyperlipemia, hyperglycemia, obesity, glucose tolerance insufficiency, insulin resistance and diabetic complications.
    Type: Grant
    Filed: March 23, 1995
    Date of Patent: November 26, 1996
    Assignee: Sankyo Company, Limited
    Inventors: Takashi Fujita, Koichi Fujimoto, Takao Yoshioka, Hiroaki Yanagisawa, Toshihiko Fujiwara, Hiroyoshi Horikoshi, Minoru Oguchi, Kunio Wada
  • Patent number: 5556864
    Abstract: Compounds of formula (I): ##STR1## [wherein: R.sup.1 is aryl; R.sup.2 is hydrogen, alkyl, alkoxy, halogen or cyano; R.sup.3 is a group of formula --B--NR.sup.4 R.sup.5, where R.sup.4 and R.sup.5 are independently hydrogen, alkyl or substituted alkyl or R.sup.4 and R.sup.5, together with the nitrogen to which they are attached, form a heterocycle, and B is alkylene or a group of formula --CH.sub.2 CH(OR.sup.6)CH.sub.2 --, where R.sup.6 is hydrogen, alkanoyl, substituted alkanoyl or arylcarbonyl, or a group of formula --D--R.sup.7, where D is a single bond or alkylene and R.sup.7 is a heterocycle; and A is alkylene; and pharmaceutically acceptable salts and esters thereof] are useful for the treatment and prevention of circulatory diseases and psychosis.
    Type: Grant
    Filed: January 5, 1995
    Date of Patent: September 17, 1996
    Assignee: Sankyo Company, Limited
    Inventors: Koichi Fujimoto, Naoki Tanaka, Fumitoshi Asai, Tomiyoshi Ito, Hiroyuki Koike
  • Patent number: 5002942
    Abstract: Compounds of formula (I): ##STR1## in which: R.sup.1 is aryl or aromatic heterocyclic; R.sup.2 and R.sup.3 are hydrogen, alkyl, alkoxy, halogen, phenyl, phenoxy, C.sub.1 -C.sub.6 alkylthio, phenylthio, C.sub.1 -C.sub.6 haloalkyl, cyano or nitro, or together are alkylene optionally containing oxygen; R.sup.4 is hydrogen, aliphatic acyl, cycloalkylcarbonyl, cycloalkoxycarbonyl, aromatic acyl, alkoxycarbonyl or benzyloxycarbonyl; R.sup.5 and R.sup.6 are alkyl; and X is oxygen, sulfur or methylene, have calcium channel blocking activity and can serve for the treatment or prophylaxis of cardiovascular diseases and disorders. They may be prepared by reacting a corresponding compound where R.sup.4 is hydrogen and the aminoethyl group is replaced by hydrogen with a compound providing the aminoethyl group and the, if required, acylating the product.
    Type: Grant
    Filed: July 21, 1989
    Date of Patent: March 26, 1991
    Assignee: Sankyo Company, Limited
    Inventors: Hiroaki Yanagisawa, Koichi Fujimoto, Yasuo Shimoji, Takuro Kanazaki, Hiroyuki Koike, Hiroshi Nishino
  • Patent number: 4805024
    Abstract: A still image pickup camera has a solid state image pickup device comprising an image pickup area, a temporary storage area, and a horizontal shift register. The signal charges in the image pickup area are transferred to the temporary storage area by the transfer pulses which are given for a vertical blanking period. Clear pulses which are equivalent to the transfer pulses are given at a desired timing in the interval between the vertical sync signals so as to enable the photo sensing interval (storage interval) in the image pickup area to be reduced and varied, thereby transferring the signal charges in the image pickup area to the temporary storage area and clearing the image pickup area.
    Type: Grant
    Filed: April 27, 1987
    Date of Patent: February 14, 1989
    Assignee: Omron Tateisi Electronics Co.
    Inventors: Masatoshi Suzuki, Yoshimasa Fujikawa, Koichi Fujimoto
  • Patent number: 4791196
    Abstract: A storage stable form of the crystalline sulfate of 7-[2-(2-aminothiazol-4-yl)-(Z)-2-methoxyiminoacetamido]-3-[5-(2-hydroxyeth yl)-4-methylthiazoliomethyl]-3-cephem-4-carboxylate has a specified X-ray diffraction pattern and is prepared by adding aqueous sulfuric acid to an aqueous solution of the compound under controlled conditions.
    Type: Grant
    Filed: September 23, 1987
    Date of Patent: December 13, 1988
    Assignee: Sankyo Company Limited
    Inventors: Junya Ide, Koichi Fujimoto
  • Patent number: 4716158
    Abstract: Compounds of formula (I): ##STR1## wherein: R.sup.1 represents a lower alkyl group selected from methyl groups and ethyl groups;R.sup.2 represents a hydrogen atom or a methyl group; andR.sup.3 represents a group selected from C.sub.1 --C.sub.5 alkoxy groups,and pharmaceutically acceptable acid addition salts thereof have valuable antibiotic activity and are suitable for oral administration. They may be prepared by a variety of synthetic routes.
    Type: Grant
    Filed: June 10, 1986
    Date of Patent: December 29, 1987
    Assignee: Sankyo Company Limited
    Inventors: Hideo Nakao, Koichi Fujimoto, Sadao Ishihara, Shinichi Sugawara, Isamu Igarashi