Abstract: A lens barrel includes a first fixed member and a second fixed member fixed to each other, a lens disposed inside the first fixed member, and an elastic member disposed between the first fixed member and the second fixed member in an optical axis direction. The elastic member has a first area that is disposed between the second fixed member and the lens and biases the lens, and a second area whose entire circumference is sandwiched between the first fixed member and the second fixed member. A surface of the first area that biases the lens is different from a surface of the second area that biases the first fixed member.

Abstract: Disclosed are methods of treating cancer comprising administering to a subject a treatment regimen comprising a compound of Formula (I): or a pharmaceutically acceptable salt thereof, and a taxane anticancer agent.

Abstract: An overcurrent protection integrated circuit includes: a current input including a first resistor receiving an input current; a current sense amplifier circuitry including a differential amplifier, a switching element, a second resistor, and a current mirror circuit; and an overcurrent determiner including a third resistor and an overcurrent protection comparator. The current sense amplifier circuitry controls, through the differential amplifier, a voltage of the second resistor to be equal to a voltage of the first resistor, and sends out, from the switching element toward the current mirror circuit, a current decreased to a predetermined ratio relative to the input current. The overcurrent determiner compares a voltage of the third resistor and a voltage of a direct-current power supply, and outputs a signal when the voltage of the third resistor exceeds the voltage of the direct-current power supply. The first resistor and the second resistor include the same metal material.

Abstract: A printing apparatus includes a print engine, a data transfer, and a controller. The data transfer has a data storage to store image data, and generates printing data using the image data stored in the data storage. The print engine prints the image on a print medium based on the printing data. The controller instructs the data transfer to execute a predetermined process with respect to the image data and to transfer the printing data to the print engine. After executing the predetermined process with respect to the image data, the data transfer executes an obtaining process of obtaining position information indicating a print position of the image in the print medium, and generates the printing data based on the position information and the image data after the predetermined process.

Abstract: An electronic apparatus includes a first operation unit and a second operation unit each operable by a user. The first operation unit is configured to change a state of at least one switch when operated. The second operation unit is configured to change a state of a first switch according to a first operation, and a state of a second switch according to a second operation following the first operation, with an operating force greater than that of the first operation. A maximum value of the operating force for the second operation with the second operation unit is different from a maximum operating force for operating the first operation unit.

Abstract: In a card edge type printed wiring board including a terminal portion provided to reach a vicinity of an edge of a base layer, an abrasion resistance layer made of metal is provided on a portion of an electric insulation layer between a board edge and an end portion of the terminal portion on a side of the board edge, and the abrasion resistance layer is spaced at an interval from the end portion of the terminal portion.

Abstract: A display apparatus according to the present invention, includes: a display panel; a display optical system for looking at the display panel; an image sensor for capturing an eye of an user looking at the display panel, the image sensor having a rectangular imaging plane; and an imaging optical system for forming an optical image of the eye on the imaging plane, wherein the imaging optical system has an optical axis that is nonparallel to an optical axis of the display optical system, and a projected line of the optical axis of the display optical system on the imaging plane is substantially parallel to a long side of the imaging plane.

Abstract: An illumination optical system that irradiates a target object with light from a light source unit includes an integrator optical system, a condenser lens, and a bandpass filter. The integrator optical system is disposed on an optical path of the light emitted from the light source unit and uniformizes an illuminance distribution of the light with which the target object is to be irradiated. The condenser lens includes a plurality of lenses and irradiates the target object with the light emitted from the integrator optical system. The bandpass filter is disposed between any two of the plurality of lenses included in the condenser lens.

Abstract: Disclosed herein is a lighting optical system comprising: a light source having a plurality of light-emitting elements configured to emit light from light-emitting surfaces, respectively; a relay optical system configured to convert a luminous intensity distribution of light emitted from each of the light-emitting elements into an irradiance distribution and to superimpose a plurality of the irradiance distributions corresponding to the plurality of light-emitting elements on each other on a superimposed surface; an optical integrator having a plurality of wavefront splitting elements arranged in parallel to each other, the plurality of wavefront splitting elements being configured to wavefront split irradiated light through the relay optical system and to transmit the wavefront split light as a plurality of pencils of light rays; and a condenser optical system configured to superimpose the plurality of pencils of light rays on each other on a surface to be irradiated.

Abstract: An electronic apparatus includes a proximity detector configured to detect proximity of an object to a viewfinder, a line-of-sight detector configured to detect line-of-sight information for a first display unit disposed inside the viewfinder, a memory storing instructions, and a processor configured to execute the instructions to determine an eye proximity state or an eye absence state based on a detection result of the line-of-sight detector, and start driving the proximity detector in a case where the processor determines the eye absence state, and stop driving the line-of-sight detector in a case where the proximity detector does not detect the proximity of the object.

Abstract: The present invention provides an image processing method capable of intuitively recognizing the three-dimensional shape of an organ by limiting the inspection range to the vicinity of the diagnostic target organ in image diagnosis. Given binary three-dimensional data representing an object in three-dimensional space, the image processing method partitions the object into individual segments with boundaries on narrow parts of the object's shape. A series of organs with no numerical differences in the boundaries on the image data can be segmented into individual organs at geometrically constricted locations because the connected organs can be identified by their shape. As a result, it is possible to examine a limited area specific to the target organ during image diagnosis, and to perform the examination while viewing the intuitive 3D shape of the organ during image interpretation.

Abstract: The present disclosure provides antibody drug conjugates and drug-linker compounds comprising one or more degrader compounds which comprise a target protein binding moiety and an E3 ubiquitin ligase binding moiety that binds a Von Hippel-Lindau E3 Ubiquitin Ligase or a Cereblon E3 Ubiquitin Ligase, and methods of use thereof.

Abstract: A three-dimensional memory device includes an alternating stack of insulating layers and electrically conductive layers, where the electrically conductive layers include word lines and drain select gate electrodes that contain plurality of drain-select-level electrically conductive strips which are located above the word lines, memory stack structures vertically extending through the alternating stack, drain-select-level isolation structures located between a respective neighboring pair of drain-select-level electrically conductive strips, and a first laterally-insulated contact via assembly including a first layer contact via structure and a first tubular insulating spacer. The first laterally-insulated contact via assembly contacts a top surface of a first word line of the word lines, and the first laterally-insulated contact via assembly laterally contacts a first drain-select-level isolation structure of the drain-select-level isolation structures.

Abstract: A display apparatus according to the present invention, includes: a display panel; a display optical system for looking at the display panel; an image sensor for capturing an eye of an user looking at the display panel, the image sensor having a rectangular imaging plane; and an imaging optical system for forming an optical image of the eye on the imaging plane, wherein the imaging optical system has an optical axis that is nonparallel to an optical axis of the display optical system, and a projected line of the optical axis of the display optical system on the imaging plane is substantially parallel to a long side of the imaging plane.

Abstract: A line-of-sight detection device according to the present invention includes: a lens; an image sensor disposed on an edge of the lens; and a plurality of light sources disposed along the edge of the lens, wherein in a 360° range around an optical axis of the lens, a number of light sources per degree is the maximum in a range on opposite side of the image sensor with respect to the optical axis of the lens.

Abstract: A semiconductor structure includes a first-tier alternating stack of first-tier insulating layers and first-tier electrically conductive layers, a second-tier alternating stack of second-tier insulating layers and second-tier electrically conductive layers that overlies the first-tier alternating stack, a memory opening vertically extending through the first-tier alternating stack and the second-tier alternating stack, a memory opening fill structure located in the memory opening and including a memory film and a vertical semiconductor channel, a first contact via structure contacting one of the first-tier electrically conductive layers, a first-tier tubular dielectric spacer including a first inner sidewall contacting the first contact via structure and contacting each first-tier electrically conductive layer that overlies said one of the first-tier electrically conductive layers, and a first-tier pillar structure vertically extending through each first-tier electrically conductive layer and having a top sur

Abstract: A semiconductor device used to control a current resonant power supply includes: a load detection circuit detecting a load state of the current resonant power supply; a frequency setting signal generation circuit generating first and second signals according to a feedback signal changing oppositely to an output signal of the current resonant power supply during a light load state and generating a frequency setting signal according to the first and second signals, and the first signal is a signal obtained by multiplying the feedback signal by a value N; a burst oscillation circuit generating a burst oscillation start signal according to the frequency setting signal; a switch control circuit generating a signal driving a first switching element and a second switching element connected in series with the current resonant power supply to turn on and off alternately according to the frequency setting signal and the burst oscillation start signal.

Abstract: Disclosed are methods of treating cancer comprising administering to a subject a treatment regimen comprising a compound of Formula (I): or a pharmaceutically acceptable salt thereof, and gemcitabine, or a pharmaceutically acceptable salt thereof.

Abstract: Disclosed are methods of treating cancer comprising administering to a subject a treatment regimen comprising a compound of Formula (I): or a pharmaceutically acceptable salt thereof, and a PD-1 inhibitor.

Abstract: A line-of-sight detection device according to the present invention includes: a lens; an image sensor disposed on an edge of the lens; and a plurality of light sources disposed along the edge of the lens, wherein in a 360° range around an optical axis of the lens, a number of light sources per degree is the maximum in a range on opposite side of the image sensor with respect to the optical axis of the lens.