Patents by Inventor Koichi Kokame

Koichi Kokame has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substrate polyeptides for von Willebrand factor cleaving protease ADAMTS-13
    Patent number: 7718763
    Abstract: The present invention relates to specific substrates for a von Willebrand factor cleaving enzyme, ADAMTS-13, as well as to diagnosis of ADAMTS-13 deficient patients, diagnostic compositions, and kits employing the substrates. Particularly preferable substrate polypeptides for ADAMTS-13 are the polypeptide which begins at amino acid 1587 and ends at amino acid 1668 of SEQ ID NO: 1 in the Sequence Listing, and the polypeptide which begins at amino acid 1596 and ends at amino acid 1668 of SEQ ID NO: 1 in the Sequence Listing. These substrate polypeptides for ADAMTS-13 have high substrate specificity and also superior quantitativeness, and a suitable size for production by recombinant methods.
    Type: Grant
    Filed: October 18, 2002
    Date of Patent: May 18, 2010
    Assignee: Japan as Represented by the President of National Cardiovascular Center
    Inventors: Toshiyuki Miyata, Koichi Kokame
  • Substrates specific to von willebrand factor cleaving protease and method of assaying the activity
    Publication number: 20070065895
    Abstract: The present invention relates to specific substrates for a von Willebrand factor cleaving enzyme, ADAMTS-13, as well as to diagnosis of ADAMTS-13 deficient patients, diagnostic compositions, and kits employing the substrates. Particularly preferable substrate polypeptides for ADAMTS-13 are the polypeptide which begins at amino acid 1587 and ends at amino acid 1668 of SEQ ID NO: 1 in the Sequence Listing, and the polypeptide which begins at amino acid 1596 and ends at amino acid 1668 of SEQ ID NO: 1 in the Sequence Listing. These substrate polypeptides for ADAMTS-13 have high substrate specificity and also superior quantitativeness, and a suitable size for production by recombinant methods.
    Type: Application
    Filed: October 18, 2002
    Publication date: March 22, 2007
    Inventors: Toshiyuki Miyata, Koichi Kokame