Patents by Inventor Koichi Koshimizu

Koichi Koshimizu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Superoxide eliminating agent
    Patent number: 5447721
    Abstract: Disclosed is a superoxide eliminating agent comprising a component extracted from natural lichens or lichen cultures, and a process for producing the same. Cosmetics containing the superoxide eliminating agent are also disclosed.
    Type: Grant
    Filed: August 30, 1994
    Date of Patent: September 5, 1995
    Assignee: Nippon Paint Co., Ltd.
    Inventors: Yasutaka Miura, Masako Higuchi, Yasuhiro Knoshita, Yoshikazu Yamamoto, Hajime Ohigashi, Koichi Koshimizu
  • Porphyrin derivatives, and their production and use
    Patent number: 4996312
    Abstract: A porphyrin compound of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are each --CH.dbd.CH.sub.2, --CH.sub.2 CHJ.sub.3, --CH(O-lower alkanoyl)CH.sub.3, --CH(OR)CH.sub.3 or --CH(O-lower alkylene-OR)CH.sub.3 ; R.sub.3 is --H, --COOH, --COO-lower alkyl, --COO-lower alkylene-OR or --COO-lower alkylene-OOC-Z; R.sub.4 is --H, -lower alkyl or -lower alkylene-OR; R is --H, -lower alkyl or a residue of a polyfunctional carboxyl compound excluding a hydrogen atom therefrom; Z is a residue of the compound of the formula (I) excluding R.sub.3 therefrom; A is --CH.sub.2 -- or --CO--; and the dotted line from the gamma-position indicates no bonding or a single direct bond; and the dotted line between the 7- and 8-positions indicates the presence of a single bond or a double bond; and its complexes with a metal(s) in the porphine skeleton and/or at the residue of the polyfunctional carboxyl compound, at least one of R.sub.1, R.sub.2, R.sub.3 and R.sub.
    Type: Grant
    Filed: April 19, 1989
    Date of Patent: February 26, 1991
    Assignees: Nihon Medi-Physics Co., Ltd., Toyo Hakka Kogyo Co., Ltd.
    Inventors: Isao Sakata, Susumu Nakajima, Koichi Koshimizu, Natsuki Samejima, Kazumi Inohara, Hiroyuki Takata, Hirohiko Yamauchi, Nobuo Ueda, Masaaki Hazue
  • Porphyrin derivatives
    Patent number: 4849207
    Abstract: A porphyrin compound of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are each --CH.dbd.CH.sub.2, --CH.sub.2 CH.sub.3, --CH(O-lower alkanoyl)CH.sub.3, --CH(OR)CH.sub.3 or --CH(O-lower alkylene-OR)CH.sub.3 ; R.sub.3 is --H, --COOH, --COO-lower alkyl, --COO-lower alkylene-OR or --COO-lower alkylene-OOC-Z; R.sub.4 is --H, -lower alkyl or -lower alkylene-OR; R is --H, -lower alkyl or a residue of a polyfunctional carboxyl compound excluding a hydrogen atom therefrom; Z is a residue of the compound of the formula (I) excluding R.sub.3 therefrom; A is --CH.sub.2 -- or --CO--; and the dotted line from the gamma-position indicates no bonding or a single direct bond; and the dotted line between the 7- and 8-positions indicates the presence of a single bond or a double bond; and its complexes with a metal(s) in the porphine skeleton and/or at the residue of the polyfuntional carboxyl compound, at least one of R.sub.1, R.sub.2, R.sub.3 and R.sub.
    Type: Grant
    Filed: October 23, 1986
    Date of Patent: July 18, 1989
    Assignees: Nihon Medi-Physics Co., Ltd., Toyo Hakka Kogyo Co., Ltd.
    Inventors: Isao Sakata, Susumu Nakajima, Koichi Koshimizu, Natsuki Samejima, Kazumi Inohara, Hiroyuki Takata, Hirohiko Yamauchi, Nobuo Ueda, Masaaki Hazue
  • 9-desoxo-9-hydroxy-pheophorbide derivatives and alkaline salts thereof
    Patent number: 4604241
    Abstract: Nine-desoxo-hydroxy-pheophorbide derivatives and alkaline salts thereof represented by the general formula: ##STR1## wherein R.sub.1 represents CH.sub.3 or CH.sub.2 OH,R.sub.2 represents H or Ac, andR.sub.3 represents H or alkali metal,are useful for treating cancer having a strong preferential affinity for cancer cells over normal cells and exerting upon irradiation a destructive effect on such cancer cells.
    Type: Grant
    Filed: October 24, 1984
    Date of Patent: August 5, 1986
    Inventors: Isao Sakata, Susumu Nakajima, Koichi Koshimizu, Natsuki Samejima, Kazumi Inohara, Hiroyuki Takata