Abstract: A lighting device includes a light source unit that outputs light, an elongated light guide including a first end surface on which the light is incident, a second end surface located opposite to the first end surface, an emitting surface, and at least one held portion provided on at least one of the longitudinal side surfaces different from the emitting surface, the light guide guiding the light from the first end surface to the second end surface, and a housing including an attachment portion to which the light source unit is attached, a housing portion that is open at an end portion on the attachment portion side and includes a housing recess to house the light guide and an exposure opening exposing the emitting surface, and a holding portion that holds the light guide in the housing recess by sandwiching the at least one held portion.

Abstract: The present invention provides identification of sequence polymorphisms in the 5-lipoxygenase gene that are present in general and asthmatic populations. The invention provides methods associated with correlating such polymorphisms with asthmatic phenotype and responsiveness to therapy. In particular, the invention demonstrates that individuals with reduced 5-lipoxygenase expression (or activity) are less responsive to treatment with 5-lipoxygenase inhibiters.

Abstract: The present invention provides identification of sequence polymorphisms in the 5-lipoxygenase gene that are present in general and asthmatic populations. The invention provides methods associated with correlating such polymorphisms with asthmatic phenotype and responsiveness to therapy. In particular, the invention demonstrates that individuals with reduced 5-lipoxygenase expression (or activity) are less responsive to treatment with 5-lipoxygenase inhibiters.