Abstract: A novel plant belonging to the Stevia Rebaudiana Bertoni variety which contains at least 4 parts by weight or more of Rebaudioside A with respect to one part by weight of Stevioside, and allows a sweetener of a good quality to be easily produced from said plant or dried leaves thereof.

Abstract: A pest repellent is disclosed having long lasting and high repelling efficacy against sanitary insects such as mosquitoes and which is highly harmless to humans. In at lease one embodiment, the pest repellent contains copaiba oil and/or an extract thereof as well as DEET and/or bisabolol.

Abstract: An gene was identified as a RA disease susceptibility gene on Human Chromosome 8, the gene coding a protein that has an amino acid sequence shown in SEQ. ID NO. 1 and that has such mutation that glycine is inserted as a 269th amino acid in the sequence. Moreover, it was found that mutation of the gene and the protein relate to onset of RA. Achieved is a method of evaluating with high accuracy the onset or onset possibility of RA by using the mutation.

Abstract: A novel plant belonging to the Stevia Rebaudiana Bertoni variety which contains at least 4 parts by weight or more of Rebaudioside A with respect to one part by weight of Stevioside, and allows a sweetener of a good quality to be easily produced from said plant or dried leaves thereof.

Abstract: A genomic DNA involved in rheumatoid arthritis, a method of diagnosing rheumatoid arthritis or a method of judging onset risk of rheumatoid arthritis, and a diagnostic kit for diagnosing rheumatoid arthritis or judging onset risk of rheumatoid arthritis, which genomic DNA comprises at least one of the following mutations in genomic DNA consisting of the base sequence of SEQ ID NO: 1: (1) substitution of thymine (t) for cytosine (c) at the position-1987; (2) substitution of guanine (g) for thymine (t) at the position-3664; and (3) substitution of cytosine (c) for adenine (a) at the position-3769.

Abstract: [Object] This invention provides a dispersion containing an insect pest repellent active substance, and an adhesive or bond, ink, resin pellets, a resin product, and a sheet or a film which can exhibit a long term repellent active effect by the particles carrying the dispersion.

Abstract: It was confirmed that the following <1> to <10> substances have an inhibitory activity on histamine release, whereby a histamine release inhibitor containing any of these substances as a major component could be obtained.

Abstract: An gene was identified as a RA disease susceptibility gene on Human Chromosome 8, the gene coding a protein that has an amino acid sequence shown in SEQ. ID NO. 1 and that has such mutation that glycine is inserted as a 269th amino acid in the sequence. Moreover, it was found that mutation of the gene and the protein relate to onset of RA. Achieved is a method of evaluating with high accuracy the onset or onset possibility of RA by using the mutation.

Abstract: A genomic DNA involved in rheumatoid arthritis, a method of diagnosing rheumatoid arthritis or a method of judging onset risk of rheumatoid arthritis, and a diagnostic kit for diagnosing rheumatoid arthritis or judging onset risk of rheumatoid arthritis, which genomic DNA comprises at least one of the following mutations in genomic DNA consisting of the base sequence of SEQ ID NO: 1:

Abstract: As a disease gene for rheumatoid arthritis present in human chromosome X and a method of diagnosing rheumatoid arthritis, a disease gene, which is a mutant of protooncogene Dbl transcribing an mRNA that encodes the cDNA of which the sequence from the 2679th to 2952nd bases is shown in SEQ ID NO: 1, which disease gene transcribes an mRNA encoding the cDNA of which the region from the 20th to 274th bases in SEQ ID NO: 1 is substituted with the sequence of SEQ ID NO: 2, and a method for diagnosing rheumatoid arthritis by detecting the mRNA of the above-described gene or its expression product in a biological specimen, is provided.

Abstract: There is disclosed a method for evaluation of the safety of a chemical compound, which includes the steps of: (a) reacting a chemical compound with recombinant yeast cells expressing, or in other words producing, human cytochrome P450 molecular species P450 1A2, P450 2C9, P450 2E1 and P450 3A4 together with a yeast NADPH-P450 reductase, which may be in the form of a fused enzyme with each of said human cytochrome P450 molecular species, or with the cell free extracts of the yeast cells; and (b) analyzing the resulting metabolite to determine the safety of the compound. According to this method, it can be determined whether a test compound will be converted into a carcinogenic or mutagenic form through the metabolism in the human liver, and whether the test compound or its metabolite has mutagenicity.

Abstract: The present invention provides an antifeedant and a contact insecticide using the components contained in Cyperaceae species. In particular, the present invention provides an insect antifeedant and a contact insecticide comprising as an active ingredient at least one compound selected from the group consisting of scabequinone, remirol, cyperaquinone and the derivatives thereof.

Abstract: The present invention provides:a diagnostic kit for liver diseases such as hepatitis C and alcoholic cirrhosis to be applied to a human serum sample, which contains an antibody capable of recognizing a human cytochrome P450; anda process for determining the concentration of a cytochrome P450 in a human serum for diagnosis of hepatitis C and alcoholic cirrhosis.

Abstract: An oligonucleotide which can hybridize with a human-derived cytochrome P450IIC18 gene, one of the enzymes participating in the metabolic decomposition of medicines, has a GC content of 40-70%, and comprises 8 to 500 nucleotide units. The use of the oligonucleotide in the recognition or amplification of a DNA having the base sequence of this gene enables the presence or absence of mutation to be readily diagnosed and analyzed before the administration of a medicine. Thus it becomes possible to determine a safe dose of a medicine which has been difficult to use because of the occurrence of individual difference in drug-metabolizing ability and to use also a medicine which takes an active form by the action of this enzyme according to individuals.

Abstract: A method of dyeing hair which comprises contacting hair with an iridoid glycoside or an aglycon thereof.

Abstract: A plant growth regulating composition which comprises as an active ingredient at least one diterpene glucoside of the formula: ##STR1## wherein R.sup.1 is a hydrogen atom or any other cation and R.sup.2 is .beta.-glucopyranosyl-(1-2)-.beta.-glucopyranosyl or 2,3-di-O-(.beta.-glucopyranosyl-.beta.-glucopyranosyl, or R.sup.1 is .beta.-glucopyranosyl and R.sup.2 is .alpha.-rhamnopyranosyl-(1-2)-.beta.-glucopyranosyl, .beta.-glucopyranosyl-(1-2)-.beta.-glucopyranosyl, 2,3-di-O-(.beta.-glucopyranosyl)-.beta.-glucopyranosyl or (3-O-.beta.-glucopyranosyl)-(2-O-.alpha.-rhamnosyl-.beta.-glcopyranosyl).