Patents by Inventor Koichiro Nishioka
Koichiro Nishioka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230293467Abstract: To provide a medicine useful for protecting renal function or reducing a dietary acid load on the kidney in mammals, particularly humans. Provided is a pharmaceutical composition containing citric acid, a pharmaceutically acceptable salt of citric acid, a hydrate of citric acid, a hydrate of the pharmaceutically acceptable salt of citric acid, or a mixture thereof. Administration of the present pharmaceutical composition makes it possible to protect renal function or reduce a dietary acid load on the kidney.Type: ApplicationFiled: March 25, 2021Publication date: September 21, 2023Inventors: Michiaki Abe, Seizo Koshiba, Koichiro Nishioka, Satomi Yamasaki, Tetsuya Sakurai, Toshiki Nakai
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Publication number: 20220202752Abstract: The present invention relates to a pharmaceutical composition for treating or preventing acidosis in chronic kidney disease with anemia, the pharmaceutical composition containing citric acid, a pharmaceutically acceptable salt of citric acid, a hydrate thereof, or a mixture thereof, in which the pharmaceutical composition is in a form of a tablet.Type: ApplicationFiled: April 24, 2020Publication date: June 30, 2022Inventors: Michiaki Abe, Seizo Koshiba, Koichiro Nishioka, Kazuhiko Kawaguchi, Satomi Yamasaki, Yasuyuki Teranaka
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Publication number: 20210393562Abstract: There is provided a pharmaceutical composition which includes, as an active ingredient, a combination drug formulation of potassium citrate and sodium citrate hydrate or a sodium bicarbonate formulation. The prevention or treatment of nocturnal polyuria is achieved by administering the pharmaceutical composition.Type: ApplicationFiled: October 16, 2019Publication date: December 23, 2021Applicant: NIPPON CHEMIPHAR CO., LTD.Inventors: Seiji ARUGA, Koichiro NISHIOKA, Satomi YAMASAKI
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Publication number: 20210386696Abstract: The present invention relates to a pharmaceutical composition for renal protection in chronic kidney disease, which contains a citric acid, a pharmaceutically acceptable salt of a citric acid, or a hydrate thereof; and a mixture of the citric acid, the pharmaceutically acceptable salt of the citric acid, and the hydrate thereof, and is a tablet.Type: ApplicationFiled: October 17, 2019Publication date: December 16, 2021Applicants: TOHOKU UNIVERSITY, NIPPON CHEMIPHAR CO., LTD.Inventors: Michiaki ABE, Seizo KOSHIBA, Koichiro NISHIOKA, Kazuhiko KAWAGUCHI, Satomi YAMASAKI, Yasuyuki TERANAKA
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Publication number: 20210196747Abstract: Provided is a metabolism improving agent that contains, for example, an alkalizing agent such as an acidosis improving agent or a urinary alkalizing agent as an active ingredient, and has actions such as improvement of insulin resistance, improvement of pituitary and adrenal functions, and reduction of visceral fat accumulation.Type: ApplicationFiled: May 24, 2019Publication date: July 1, 2021Applicants: University of the Ryukyus, Nippon Chemiphar Co., Ltd.Inventors: Hiroaki MASUZAKI, Hideki NAKAMURA, Toshitake HIRAI, Kaoru HARA, Takashi KANDA, Satomi YAMASAKI, Tadashi KOBAYASHI, Koichiro NISHIOKA
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Publication number: 20210121426Abstract: The present invention relates to a food composition comprising an alkalinizing agent, particularly an alkali metal salt of citric acid. Ingestion of the food composition maintains kidney function.Type: ApplicationFiled: March 13, 2018Publication date: April 29, 2021Applicants: TOHOKU UNIVERSITY, NIPPON CHEMIPHAR CO., LTD.Inventors: Michiaki ABE, Seizo KOSHIBA, Koichiro NISHIOKA, Kazuhiko KAWAGUCHI, Satomi YAMASAKI, Yasuyuki TERANAKA
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Patent number: 6706705Abstract: The present invention provides a new compound which shows slow and continuous blood pressure reducing action and is useful as an antihypertensive agent. The invention resides in a quinazoline derivative of the following formula (I) and its pharmaceutically acceptable salt: in which, each of R1 and R2 is H or an alkyl group of 1 to 6 carbon atoms, or R1 and R2 are combined to form an ethylene group; each of R3 and R4 is an alkyl group of 1 to 6 carbon atoms; R5 is a hydrogen atom, a hydroxyl group, an alkyl group of 1 to 6 carbon atoms, or an alkoxy group of 1 to 6 carbon atoms; each of R6 and R7 is a hydrogen atom or an alkyl group of 1 to 6 carbon atoms; and n is 2 or 3. The invention further resides in an antihypertensive agent containing the above compound.Type: GrantFiled: March 28, 1997Date of Patent: March 16, 2004Assignee: Nippon Chemiphar Co., Ltd.Inventors: Koichiro Nishioka, Toshihiro Takahashi, Yutaka Nomura
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Patent number: 6689785Abstract: Novel epoxysuccinamide derivatives represented by the general formula (1) or physiologically acceptable salts thereof, which are useful particularly as remedies for bone diseases and arthritis, wherein R1 and R3 are each hydrogen, alkyl, alkenyl, alkynyl, aryl, aralkyl, a heterocyclic group, or a heterocyclic-alkyl group; R2 is alkyl, alkenyl, alkynyl, aryl, aralkyl, a heterocyclic group, or a hetericyclic-alkyl group; X is —O— or —NR4— (wherein R4 is hydrogen, alkyl, aryl, aralkyl, a heterocyclic group, or a heterocyclic-alkyl group; Y1 is OR5, SR6, or NR7R8 (wherein each of R5, R6 and R7 is hydrogen, alkyl, aryl, aralkyl, acyl, a heterocyclic group, or a heterocyclic-alkyl group, and R8 is the same as defined for R4); and Y2 is hydrogen or alkyl, or alternatively Y1 and Y2 can be combined to form ═O, ═S, ═N—R9, or ═N—OR10 (wherein each of R9 and R10 is the same as defined for R4), provided that each of the alkyl, aryl and heterocyclic groups defined foType: GrantFiled: January 8, 2002Date of Patent: February 10, 2004Assignee: Nippon Chemiphar Co., Ltd.Inventors: Yutaka Nomura, Toshihiro Takahashi, Yasushi Yoshino, Koichiro Nishioka
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Publication number: 20020091131Abstract: Novel epoxysuccinamide derivatives represented by the general formula (1) or physiologically acceptable salts thereof, which are useful particularly as remedies for bone diseases and arthritis, wherein R1 and R3 are each hydrogen, alkyl, alkenyl, alkynyl, aryl, aralkyl, a heterocyclic group, or a heterocyclic-alkyl group; R2 is alkyl, alkenyl, alkynyl, aryl, aralkyl, a heterocyclic group, or a hetericyclic-alkyl group; X is —O— or —NR4— (wherein R4 is hydrogen, alkyl, aryl, aralkyl, a heterocyclic group, or a heterocyclic-alkyl group; Y1 is OR5, SR6, or NR7R8 (wherein each of R5, R6 and R7 is hydrogen, alkyl, aryl, aralkyl, acyl, a heterocyclic group, or a heterocyclic-alkyl group, and R8 is the same as defined for R4); and Y2 is hydrogen or alkyl, or alternatively Y1 and Y2 can be combined to form ═O, ═S, ═N—R9, or ═N—OR10 (wherein each of R9 and R10 is the same as defined for R4), provided that each of the alkyl, aryl and heterocyclic groups defined foType: ApplicationFiled: January 8, 2002Publication date: July 11, 2002Inventors: Yutaka Nomura, Toshihiro Takahashi, Yasushi Yoshino, Koichiro Nishioka
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Patent number: 6387908Abstract: Epoxysuccinamide derivatives of the formula (1): wherein R1 is hydrogen, alkyl, alkenyl, alkynyl, aryl, or aralkyl; R2 is alkyl, alkenyl, alkynyl, aryl, or aralkyl; R3 is hydrogen, alkyl, alkenyl, alkynyl, aryl, aralkyl, heterocyclic, or heterocyclic-alkyl; X is —O— or —NR4— (R4 is hydrogen, alkyl, aryl, aralkyl, heterocyclic, or heterocyclic-alkyl); Y1 is OR5, SR6, or NR7R8; and Y2 is hydrogen or alkyl. The compounds are useful as remedies for bone diseases and arthritis.Type: GrantFiled: May 5, 2000Date of Patent: May 14, 2002Assignee: Nippon Chemiphar Co., Ltd.Inventors: Yutaka Nomura, Toshihiro Takahashi, Yasushi Yoshino, Koichiro Nishioka