Patents by Inventor Koichiro Saruhashi
Koichiro Saruhashi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230383245Abstract: The present invention provides a culture method of cells and/or tissues including culturing cells and/or tissues in a suspended state by using a medium composition having an effect of preventing sedimentation of cells and/or tissues, which is afforded by substantially retaining the cells and/or tissues, without substantially increasing the viscosity of the solution, by nanofibers which have been added to the solution and uniformly dispersed in the liquid medium, and the like.Type: ApplicationFiled: August 8, 2023Publication date: November 30, 2023Applicant: NISSAN CHEMICAL CORPORATIONInventors: Hisato HAYASHI, Misayo OTANI, Koichiro SARUHASHI, Taito NISHINO, Takehisa IWAMA, Tatsuro KANAKI, Ayako AIHARA
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Patent number: 11555080Abstract: The present invention provides a method for removing a divalent metal cation from a macromolecular compound having an anionic functional group and containing the divalent metal cation, including (1) suspending a macromolecular compound having an anionic functional group and containing a divalent metal cation in a solution in which an electrolyte that releases an alkali metal ion is dissolved at a concentration at which the macromolecular compound is salted out, and (2) performing, in the obtained suspension, an ion exchange reaction to exchange the divalent metal cation contained in the macromolecular compound with the alkali metal ion.Type: GrantFiled: May 1, 2018Date of Patent: January 17, 2023Assignee: NISSAN CHEMICAL CORPORATIONInventors: Koichiro Saruhashi, Yoko Okuni, Keisuke Morodome, Jun Takeoka
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Publication number: 20220306985Abstract: The present invention provides a culture method of cells and/or tissues including culturing cells and/or tissues in a suspended state by using a medium composition wherein indeterminate structures are formed in a liquid medium, the structures are uniformly dispersed in the solution and substantially retain the cells and/or tissues without substantially increasing the viscosity of the solution, thus affording an effect of preventing sedimentation thereof, and the likeType: ApplicationFiled: May 23, 2022Publication date: September 29, 2022Applicants: Nissan Chemical Industries, Ltd., Kyoto UniversityInventors: Taito NISHINO, Tatsuro KANAKI, Ayako OTANI, Koichiro SARUHASHI, Misayo Tomura, Takehisa IWAMA, Masato HORIKAWA, Norio NAKATSUJI, Tomomi OTSUJI
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Publication number: 20220267480Abstract: The present invention provides a method capable of easily mixing any liquid containing a linking substance such as a divalent metal cation and the like with a liquid containing a particular compound at a high concentration, and capable of producing a liquid medium composition comprising fine structures dispersed therein, and a production device therefor and a kit therefor. The first liquid containing a particular compound is passed through a through-hole having a given cross-sectional area formed in a nozzle part at a given flow rate and injected into the second liquid at a given flow rate. By this simple operation, a structure in which the particular compound is bonded via the linking substance is formed, and the structure is preferably dispersed in a mixture of the both liquids.Type: ApplicationFiled: May 11, 2022Publication date: August 25, 2022Applicant: NISSAN CHEMICAL INDUSTRIES, LTD.Inventors: Hisato HAYASHI, Koichiro SARUHASHI, Tatsuro KANAKI
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Patent number: 11371013Abstract: The present invention provides a culture method of cells and/or tissues including culturing cells and/or tissues in a suspended state by using a medium composition wherein indeterminate structures are formed in a liquid medium, the structures are uniformly dispersed in the solution and substantially retain the cells and/or tissues without substantially increasing the viscosity of the solution, thus affording an effect of preventing sedimentation thereof, and the like.Type: GrantFiled: February 26, 2020Date of Patent: June 28, 2022Assignees: Nissan Chemical Industries, Ltd., Kyoto UniversityInventors: Taito Nishino, Tatsuro Kanaki, Ayako Otani, Koichiro Saruhashi, Misayo Tomura, Takehisa Iwama, Masato Horikawa, Norio Nakatsuji, Tomomi Otsuji
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Patent number: 11345762Abstract: The present invention provides a method capable of easily mixing any liquid containing a linking substance such as a divalent metal cation and the like with a liquid containing a particular compound at a high concentration, and capable of producing a liquid medium composition comprising fine structures dispersed therein, and a production device therefor and a kit therefor. The first liquid containing a particular compound is passed through a through-hole having a given cross-sectional area formed in a nozzle part at a given flow rate and injected into the second liquid at a given flow rate. By this simple operation, a structure in which the particular compound is bonded via the linking substance is formed, and the structure is preferably dispersed in a mixture of the both liquids.Type: GrantFiled: April 7, 2016Date of Patent: May 31, 2022Assignee: NISSAN CHEMICAL INDUSTRIES, LTD.Inventors: Hisato Hayashi, Koichiro Saruhashi, Tatsuro Kanaki
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Publication number: 20200208101Abstract: The present invention provides a culture method of cells and/or tissues including culturing cells and/or tissues in a suspended state by using a medium composition wherein indeterminate structures are formed in a liquid medium, the structures are uniformly dispersed in the solution and substantially retain the cells and/or tissues without substantially increasing the viscosity of the solution, thus affording an effect of preventing sedimentation thereof, and the likeType: ApplicationFiled: February 26, 2020Publication date: July 2, 2020Applicants: Nissan Chemical Industries, Ltd., Kyoto UniversityInventors: Taito NISHINO, Tatsuro KANAKI, Ayako OTANI, Koichiro SARUHASHI, Misayo Tomura, Takehisa IWAMA, Masato HORIKAWA, Norio NAKATSUJI, Tomomi OTSUJI
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Publication number: 20200165194Abstract: The present invention provides a medium additive composition containing a compound represented by the following formula (I), or a salt thereof: {wherein each symbol is as defined in the DESCRIPTION.Type: ApplicationFiled: July 27, 2018Publication date: May 28, 2020Applicant: NISSAN CHEMICAL CORPORATIONInventors: Taito NISHINO, Ayako AIHARA, Keiichiro OTSUKA, Koichiro SARUHASHI, Takumi MIKASHIMA, Masahiro KAMAURA
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Publication number: 20200095542Abstract: The present invention provides a culture method of cells and/or tissues including culturing cells and/or tissues in a suspended state by using a medium composition having an effect of preventing sedimentation of cells and/or tissues, which is afforded by substantially retaining the cells and/or tissues without substantially increasing the viscosity of the solution by nanofibers which have been added to the solution and uniformly dispersed in the liquid medium, and the like.Type: ApplicationFiled: October 24, 2019Publication date: March 26, 2020Applicant: NISSAN CHEMICAL CORPORATIONInventors: Hisato HAYASHI, Misayo OTANI, Koichiro SARUHASHI, Taito NISHINO, Takehisa IWAMA, Tatsuro KANAKI, Ayako AIHARA
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Patent number: 10590380Abstract: The present invention provides a culture method of cells and/or tissues including culturing cells and/or tissues in a suspended state by using a medium composition wherein indeterminate structures are formed in a liquid medium, the structures are uniformly dispersed in the solution and substantially retain the cells and/or tissues without substantially increasing the viscosity of the solution, thus affording an effect of preventing sedimentation thereof, and the like.Type: GrantFiled: March 2, 2017Date of Patent: March 17, 2020Assignees: Nissan Chemical Industries, Ltd., Kyoto UniversityInventors: Taito Nishino, Tatsuro Kanaki, Ayako Otani, Koichiro Saruhashi, Misayo Tomura, Takehisa Iwama, Masato Horikawa, Norio Nakatsuji, Tomomi Otsuji
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Publication number: 20200055962Abstract: The present invention provides a method for removing a divalent metal cation from a macromolecular compound having an anionic functional group and containing the divalent metal cation, including (1) suspending a macromolecular compound having an anionic functional group and containing a divalent metal cation in a solution in which an electrolyte that releases an alkali metal ion is dissolved at a concentration at which the macromolecular compound is salted out, and (2) performing, in the obtained suspension, an ion exchange reaction to exchange the divalent metal cation contained in the macromolecular compound with the alkali metal ion.Type: ApplicationFiled: May 1, 2018Publication date: February 20, 2020Applicant: NISSAN CHEMICAL CORPORATIONInventors: Koichiro SARUHASHI, Yoko OKUNI, Keisuke MORODOME, Jun TAKEOKA
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Patent number: 10544181Abstract: A novel gelator including a sugar derivative; a gelator including a compound of Formula (1) or Formula (2): wherein R1 is a linear or branched alkyl group having a carbon atom number of 9 to 20, a cyclic alkyl group having a carbon atom number of 13 to 20, or a linear or branched alkenyl group having a carbon atom number of 9 to 20, R2 is a hydrogen atom, a linear or branched alkyl group having a carbon atom number of 1 to 10, or an aryl group optionally having a substituent, and R3 and R4 are hydroxy groups.Type: GrantFiled: August 25, 2016Date of Patent: January 28, 2020Assignees: KYUSHU UNIVERSITY, INSTITUTE OF SYSTEMS, INFORMATION TECHNOLOGIES AND NANOTECHNOLOGIES, NISSAN CHEMICAL INDUSTRIES, LTD.Inventors: Fumiyasu Ono, Koichiro Saruhashi, Osamu Hirata, Seiji Shinkai, Tatsuhiro Yamamoto
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Patent number: 10519419Abstract: The present invention provides a production method of a medium composition, including previously removing divalent metal cations contained in a polymer compound having an anionic functional group, preparing a dry powder of the polymer compound, and mixing the dry powder and the medium, and the like. The present invention also provides a purification method of a polymer compound having an anionic functional group, which includes mixing a suspension of the polymer compound having an anionic functional group in water and a cation exchanger that exchanges a divalent metal cation with a monovalent metal cation to give a polymer compound having an anionic functional group, which shows a reduced amount of contaminating divalent metal cations.Type: GrantFiled: January 23, 2015Date of Patent: December 31, 2019Assignee: NISSAN CHEMICAL CORPORATIONInventors: Misayo Otani, Koichiro Saruhashi, Taito Nishino, Ayako Aihara, Hisashi Ishii, Keigo Matsumoto
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Patent number: 10487308Abstract: The present invention provides a culture method of cells and/or tissues including culturing cells and/or tissues in a suspended state by using a medium composition having an effect of preventing sedimentation of cells and/or tissues, which is afforded by substantially retaining the cells and/or tissues without substantially increasing the viscosity of the solution by nanofibers which have been added to the solution and uniformly dispersed in the liquid medium, and the like.Type: GrantFiled: January 23, 2015Date of Patent: November 26, 2019Assignee: NISSAN CHEMICAL CORPORATIONInventors: Hisato Hayashi, Misayo Otani, Koichiro Saruhashi, Taito Nishino, Takehisa Iwama, Tatsuro Kanaki, Ayako Aihara
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Publication number: 20190264158Abstract: A method for producing a liquid medium composition, including mixing a first liquid A1 containing a particular compound and a second liquid B1 containing a linking substance, and the method is carried out using a production apparatus. The production apparatus has a container 1 provided with at least two openings 2, 3 in a wall, the two openings are connected to each other by a tube 4 outside the container, and the tube has a part with a shape and flexibility that render the tube placeable as a pumping tube into a peristaltic pump 5. In the production method, the peristaltic pump is operated, and the first liquid and the second liquid are mixed by circulating them to form the object liquid medium composition in the container.Type: ApplicationFiled: July 21, 2017Publication date: August 29, 2019Applicants: NISSAN CHEMICAL CORPORATION, KOHJIN BIO CO., LTD.Inventors: Yoshio TAKEUCHI, Tatsuro KANAKI, Koichiro SARUHASHI
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Publication number: 20180280296Abstract: A stable high-water-content W/O-type emulsion gel comprising: a gelator composed of a compound of Formula (1) or (2) below (wherein, R1 and R3 are each independently a linear or branched alkyl group having a carbon atom number of 1 to 20, a cyclic alkyl group having a carbon atom number of 3 to 20, or a linear or branched alkenyl group having a carbon atom number of 2 to 20, n is an integer of 0 or 1 to 4, R2 is a hydrogen atom, a linear or branched alkyl group having a carbon atom number of 1 to 10, or an aryl group optionally having a substituent, and R4 and R5 are a hydroxyl group); a surfactant; and a mixed solvent of a hydrophobic organic solvent and water, wherein the content of the gelator is 0.1-20% by mass with respect to the mass of the mixed solvent.Type: ApplicationFiled: August 25, 2016Publication date: October 4, 2018Applicants: NISSAN CHEMICAL INDUSTRIES, LTD., KYUSHU UNIVERSITY, INSTITUTE OF SYSTEMS, INFORMATION TECHNOLOGIES AND NANOTECHNOLOGIESInventors: Koichiro SARUHASHI, Osamu HIRATA, Fumiyasu ONO, Seiji SHINKAI, Tatsuhiro YAMAMOTO
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Publication number: 20180208618Abstract: A novel gelator including a sugar derivative; a gelator including a compound of Formula (1) or Formula (2): wherein R1 is a linear or branched alkyl group having a carbon atom number of 9 to 20, a cyclic alkyl group having a carbon atom number of 13 to 20, or a linear or branched alkenyl group having a carbon atom number of 9 to 20, R2 is a hydrogen atom, a linear or branched alkyl group having a carbon atom number of 1 to 10, or an aryl group optionally having a substituent, and R3 and R4 are hydroxy groups.Type: ApplicationFiled: August 25, 2016Publication date: July 26, 2018Applicants: KYUSHU UNIVERSITY, Institute of Systems, Information Technologies and Nanotechnologies, NISSAN CHEMICAL INDUSTRIES, LTD.Inventors: Fumiyasu ONO, Koichiro SARUHASHI, Osamu HIRATA, Seiji SHINKAI, Tatsuhiro YAMAMOTO
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Patent number: 10017805Abstract: The present invention relates to a protein production accelerating agent that has enabled to largely increase the produced amount of a desired protein by adding polysaccharides to a medium for animal cells containing a serum or serum alternative, and a production method of a protein using a medium containing the protein production accelerating agent.Type: GrantFiled: August 23, 2013Date of Patent: July 10, 2018Assignees: Nissan Chemical Industries, Ltd., Institute of National Colleges of Tehcnology, JapanInventors: Misayo Tomura, Takehisa Iwama, Koichiro Saruhashi, Taito Nishino, Masato Horikawa, Hiroharu Kawahara
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Publication number: 20180112013Abstract: The present invention provides a method capable of easily mixing any liquid containing a linking substance such as a divalent metal cation and the like with a liquid containing a particular compound at a high concentration, and capable of producing a liquid medium composition comprising fine structures dispersed therein, and a production device therefor and a kit therefor. The first liquid containing a particular compound is passed through a through-hole having a given cross-sectional area formed in a nozzle part at a given flow rate and injected into the second liquid at a given flow rate. By this simple operation, a structure in which the particular compound is bonded via the linking substance is formed, and the structure is preferably dispersed in a mixture of the both liquids.Type: ApplicationFiled: April 7, 2016Publication date: April 26, 2018Applicant: NISSAN CHEMICAL INDUSTRIES, LTD.Inventors: Hisato HAYASHI, Koichiro SARUHASHI, Tatsuro KANAKI
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Publication number: 20170175077Abstract: The present invention provides a culture method of cells and/or tissues including culturing cells and/or tissues in a suspended state by using a medium composition wherein indeterminate structures are formed in a liquid medium, the structures are uniformly dispersed in the solution and substantially retain the cells and/or tissues without substantially increasing the viscosity of the solution, thus affording an effect of preventing sedimentation thereof, and the likeType: ApplicationFiled: March 2, 2017Publication date: June 22, 2017Applicants: Nissan Chemical Industries, Ltd., Kyoto UniversityInventors: Taito NISHINO, Tatsuro KANAKI, Ayako OTANI, Koichiro SARUHASHI, Misayo Tomura, Takehisa IWAMA, Masato HORIKAWA, Norio NAKATSUJI, Tomomi OTSUJI