Abstract: The present invention relates to a pharmaceutical composition and method for preventing or treating a zoster-associated pain. The inventors found that an N-{2-[(4-substituted phenyl)amino]-2-oxoethyl}tetrahydro-2H-thiopyran-4-carboxamide compound useful as a varicella-zoster virus (VZV) unexpectedly has the effect to prevent an irreversible nerve degeneration accompanied by herpes virus infection, and therefore is also useful as an agent for preventing or treating zoster-associated pain, and thus accomplished the present invention.

Abstract: [Problems] To provide an agent useful for the prevention or treatment of various diseases associated with the infection with acyclovir-resistant viruses of the family Herpesviridae, specifically various infectious caused by herpes viruses, such as varicella associated with varicella-zoster virus infection, herpes zoster associated with recurrent infection with latent varicella-zoster virus, and herpes labialis, herpes encephalitis and genital herpes associated with HSV-1 and HSV-2 infection, and the like. [Means for Solving Problems] An N-[2-[(4-substituted phenyl)amino]-2-oxoethyl]tetrahydro-2H-thiopyran-4-carboxamide derivative in which the phenyl group is substituted at position 4 by a specific 5- or 6-membered heteroaryl group. This derivative has an excellent anti-viral activity against acyclovir-resistant herpes viruses and, therefore, is effective for the treatment of the diseases as mentioned above.

Abstract: A method of producing a pore-free polynorbornene article having thick-walled portions is provided. The method comprises providing a monomer charge containing at least one norbornene monomer having a tricyclic or higher cyclic structure; introducing the monomer charge into a mold at a temperature greater than the inside mold temperature; polymerizing the monomer charge under pressure via a ring-opening catalyst system; cooling the molded article; and removing the molded article from the mold.

Abstract: An organic fluorine compound as a mold release agent wherein at least one norbornene compound is polymerized by ring opening in a mold coated with said release agent. The organic fluorine compound release agent can be used in combination with a conventional mold release agent.

Abstract: Process for preparing a pore-free polynorbornene product by bulk polymerizing a monomer charge containing at least one norbornene monomer having tricyclic or higher cyclic structure with a metathesis catalyst by controlling maximum exotherm temperature to a level of 160.degree. C. or below or by controlling the temperature difference to 80.degree. C. or below between the inner and exterior temperatures during the cooling period of said product from the maximum exotherm to the glass transition temperature of said product.