Abstract: An object of the present invention is to provide methods of discovering drugs effective for tough targets, which have conventionally been discovered only with difficulty. The present invention relates to novel methods for cyclizing peptide compounds, and novel peptide compounds and libraries comprising the same, to achieve the above object.

Abstract: A continuous method of press forming a sheet resin, which is capable of subjecting to a consecutive process the steps of extruding a molten resin, forming the molten resin into a sheet resin strip, cutting the sheet resin strip into sheet resin pieces and press forming the sheet resin pieces. These steps are continuously carried out synchronously with one another by means of synchronizing devices, while the sheet resin is maintained at the desired temperature so as to possess proper thermoplasticity and surface stiffness through the medium of two thermal controls.

Abstract: A method of press forming plastic material by a press having upper and lower moulds, in which melt plastic material is extruded from an extruder and is supplied to a metering chamber. The metering chamber supplies a metered amount of material into a movable arm which moves over the mould surface area of the lower mould and injects the material from an injection port of the arm, while the arm is moving. By suitably controlling the movement of the arm and material supply from the metering chamber, a desired charge pattern formed by a parapet shaped injected material can be formed. Automatic programming by a microprocessing unit is also easy.