Abstract: The present invention provides a method for treating or preventing a renal injury-related disease such as diabetic nephropathy comprising administering to a mammal a therapeutically effective amount of 2-({[7-hydroxy-5-(2-phenylethyl)-[1,2,4]triazolo[1,5-a]pyridin-8-yl]carbonyl}amino)acetic acid or a pharmaceutically acceptable salt thereof, and a novel pharmaceutical use of the aforementioned compound such as a pharmaceutical composition for treating or preventing a renal injury-related disease and the like comprising the aforementioned compound or a pharmaceutically acceptable salt thereof.

Abstract: Disclosed is a composition for use for topical administration onto the upper and/or lower eyelid of a subject. The composition includes a polyaphron, and the polyaphron includes: at least one hydrophilic phase; at least one hydrophobic phase; and at least one surfactant selected from ionic surfactants and/or non-ionic surfactants.

Abstract: Provided is an aqueous ophthalmic solution comprising diquafosol or a salt thereof at a concentration of 0.1% to 10% (w/v) and a chlorhexidine at a concentration of 0.0001% to 0.1% (w/v).

Abstract: Regarding Diquafosol ophthalmic solution comprising a chelating agent at a concentration of 0.0001 to 1% (w/v), formation of insoluble precipitates found in Diquafosol ophthalmic solution during storage of the solution, as well as deterioration of the filtration performance in the course of production (course of filtration sterilization), have been inhibited. Further, in Diquafosol ophthalmic solution comprising a chelating agent, reduction of eye irritation and enhancement of the preservative effectiveness have been confirmed, in comparison to Diquafosol ophthalmic solution comprising no chelating agent. Accordingly, the present invention has been confirmed to provide physicochemical properties that are stable during the courses of production and distribution as well as the course of storage by a patient, and also reduce eye irritation and enhance preservative effectiveness.

Abstract: [Task] To provide a method that makes it possible to easily, inexpensively and accurately manufacture a machined part with a simple configuration and an excellent strength. [Means for Solution] In a method for manufacturing a machined part according to the invention, a dislocation is partially introduced (S3), through shot peening, only into a surface layer of a raw material 1 in a region 1a to be machined, graphite is partially deposited (S4), through heating, only in the surface layer of the region 1a to be machined, and then, the surface layer of the region 1a where graphite is deposited is removed, through machining (S5), only by an amount corresponding to a working margin 1c, thereby manufacturing a machined part 1?.

Abstract: Regarding Diquafosol ophthalmic solution comprising a chelating agent at a concentration of 0.0001 to 1% (w/v), formation of insoluble precipitates found in Diquafosol ophthalmic solution during storage of the solution, as well as deterioration of the filtration performance in the course of production (course of filtration sterilization), have been inhibited. Further, in Diquafosol ophthalmic solution comprising a chelating agent, reduction of eye irritation and enhancement of the preservative effectiveness have been confirmed, in comparison to Diquafosol ophthalmic solution comprising no chelating agent. Accordingly, the present invention has been confirmed to provide physicochemical properties that are stable during the courses of production and distribution as well as the course of storage by a patient, and also reduce eye irritation and enhance preservative effectiveness.

Abstract: A method of manufacturing a ferrous metal component includes: performing an element removal treatment on a workpiece formed of a ferrous metal material; and performing a surface hardening treatment on the workpiece through a carburizing treatment after the element removal treatment. In this method, the element removal treatment is performed under a condition of a higher temperature and a lower pressure than in the carburizing treatment.

Abstract: A distorted image (S) is acquired through a photographing operation using a wide-angle lens or an omnidirectional mirror. A cutting reference point (P) for cutting a partial cut region from the distorted image is set. The cut region is set according to the cutting reference point. An eye vector (n) corresponding to the cutting reference point is set with a photographing viewpoint of the distorted image as a base point. The cut region is shifted by a predetermined distance from the cutting reference point. The shifted cut region is transformed through image transformation to transform the distorted image into a planar regular image (T?) according to the eye vector. The shifted cut region (E?) is transformed.

Abstract: A manufacturing method of steel in which an element of the treatment gas is dissolved and diffused includes heating the steel, making a treatment gas contact a surface of the steel such that an element of the treatment gas dissolves and diffuses from the surface of the steel into a surface layer thereof, and reducing a concentration of the treatment gas near a non-treatment surface that is a portion of the surface of the steel.

Abstract: A method of heat treating metal articles includes a heating process of heating a metal workpiece under a predetermined heating condition, a cooling process of cooling the workpiece by spraying mist of cooling water to the workpiece under a predetermined cooling condition after heating the workpiece, and a surface treatment process of adjusting a surface roughness of the workpiece prior to the heating process in line with a thermal distribution in the workpiece heated during the heating process.

Abstract: [Task] To provide a method that makes it possible to easily, inexpensively and accurately manufacture a machined part with a simple configuration and an excellent strength. [Means for Solution] In a method for manufacturing a machined part according to the invention, a dislocation is partially introduced (S3), through shot peening, only into a surface layer of a raw material 1 in a region 1a to be machined, graphite is partially deposited (S4), through heating, only in the surface layer of the region 1a to be machined, and then, the surface layer of the region 1a where graphite is deposited is removed, through machining (S5), only by an amount corresponding to a working margin 1c, thereby manufacturing a machined part 1?.

Abstract: Regarding Diquafosol ophthalmic solution comprising a chelating agent at a concentration of 0.0001 to 1% (w/v), formation of insoluble precipitates found in Diquafosol ophthalmic solution during storage of the solution, as well as deterioration of the filtration performance in the course of production (course of filtration sterilization), have been inhibited. Further, in Diquafosol ophthalmic solution comprising a chelating agent, reduction of eye irritation and enhancement of the preservative effectiveness have been confirmed, in comparison to Diquafosol ophthalmic solution comprising no chelating agent. Accordingly, the present invention has been confirmed to provide physicochemical properties that are stable during the courses of production and distribution as well as the course of storage by a patient, and also reduce eye irritation and enhance preservative effectiveness.

Abstract: A distorted image (S) is acquired through a photographing operation using a wide-angle lens or an omnidirectional mirror. A cutting reference point (P) for cutting a partial cut region from the distorted image is set. The cut region is set according to the cutting reference point. An eye vector (n) corresponding to the cutting reference point is set with a photographing viewpoint of the distorted image as a base point. The cut region is shifted by a predetermined distance from the cutting reference point. The shifted cut region is transformed through image transformation to transform the distorted image into a planar regular image (T?) according to the eye vector. The shifted cut region (E?) is transformed.

Abstract: Regarding Diquafosol ophthalmic solution comprising a chelating agent, formation of insoluble precipitates found in Diquafosol ophthalmic solution during its storage, as well as deterioration of the filtration performance in the course of production (filtration sterilization), have been inhibited. Further, in Diquafosol ophthalmic solution comprising a chelating agent, enhancement of preservative effectiveness has been confirmed. Accordingly, the present invention provides Diquafosol ophthalmic solution having physicochemical properties that are stable during the courses of production and distribution as well as the course of storage by a patient. Particularly in the course of production, the solution can be subjected to efficient filtration sterilization. Moreover, the solution has excellent preservative effectiveness.

Abstract: An image converter for performing processes of cutting out a part of a distorted circular image photographed by use of a fisheye lens and converting the part into a planar regular image. The image converter includes a distorted circular image memory, a planar regular image memory, a parameter input unit, a corresponding coordinate calculating unit, and a planar regular image forming unit.

Abstract: An aqueous ophthalmic solution containing hyaluronic acid or a salt thereof at a concentration from 0.03 to 0.5% (w/v) and propylene glycol at a concentration from 0.1 to 1.0% (w/v) comprises as a sole preservative, benzalkonium chloride at a concentration from 0.001 to 0.002% (w/v) and comprises an ionic tonicity agent at such a concentration that an osmotic pressure ratio of the ophthalmic solution becomes from 0.9 to 1.1.

Abstract: To provide a conference system, a monitoring system, an image processing apparatus, an image processing method and A non-transitory computer-readable storage medium that stores a computer-image processing program capable of accurately and effectively recognizing an object based on a fisheye-distorted image photographed at a wide angle. When an instruction of selecting an arbitrary point Ci(ui, vi) of a 2D-viewable planar regular image generated based on a fisheye-distorted image S photographed by a fisheye lens is received, point Si(xi, yi) on the fisheye-distorted image S is calculated as a coordinate corresponding to Ci(ui, vi), and a pixel information group configuring the planar regular image is newly generated based on a pixel information group configuring the fisheye-distorted image S.

Abstract: It is to provide a novel head-and-neck tumor proliferation inhibitor, head-and-neck tumor metastasis inhibitor and pharmaceutical composition for treating a head-and-neck tumor. The present invention is characterized by using an inhibitory substance of a microRNA whose expression increases in a head-and-neck tumor and/or a promoting substance of a microRNA whose expression decreases in a head-and-neck tumor. Preferred examples of the microRNA whose expression increases in a head-and-neck tumor include miR-455-3p, miR-455-5p, miR-130b, miR-130b*, miR-801, miR-196a, miR-21 and miR-31. Preferred examples of the microRNA whose expression decreases in a head-and-neck tumor include miR-133b, miR-145 and miR-375.

Abstract: Any given part is cut out from a distorted circular image photographed by use of a fisheye lens and converted into a planar regular image with less distortion. A virtual sphere H having a radius R on a distorted circular image S on an XY plane is defined, thereby allowing a user to designate a cut-out center point P, a magnification m, and a planar inclination angle ?. A visual line vector n passing through an intersecting point Q immediately above the point P is determined to define an UV orthogonal coordinate system having an orientation depending on the angle ? on a plane orthogonal to a visual line vector n at a point G in which a distance between two points OG is given as m·R. The UV orthogonal coordinate system is curved along the side face C of a “virtual cylindrical column in which the point G forms one point on the side face to have a straight line V? parallel to the V axis and also passing through the point O as a central axis,” thereby defining the UV curved coordinate system.

Abstract: To provide a method of manufacturing a carburized part contributable to cost reduction, a portion intended for a non-carburizing portion is treated to a surface roughness corresponding to Rz 50 like a first work surface and a portion intended for a carburizing portion is treated to a surface roughness corresponding to Rz 1.5 like a second work surface.