Patents by Inventor Koji Kitaguchi

Koji Kitaguchi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4402948
    Abstract: Oxygenated sterylglycoside derivatives of the formula (I) wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are the same or different and each is hydrogen or lower alkanoyl, Y is ##STR1## and R.sub.5 is 4-methylpentyl, 3-ethyl-4-methylpentyl or 3-ethyl-4-methyl-1-pentenyl are useful for their hemostatic and capillary stabilizing effects.
    Type: Grant
    Filed: January 23, 1981
    Date of Patent: September 6, 1983
    Assignee: Nippon Shinyaku Co., Ltd.
    Inventors: Shingo Matsumura, Hiroshi Enomoto, Koji Kitaguchi, Masakuni Ozaki, Masahiko Kitano, Toshihiro Okamura, Haruo Tanaka
  • Patent number: 4210671
    Abstract: A process for the preparation of amide derivatives of abietic acid, dehydroabietic acid, dihydroabietic acid or tetrahydroabietic acid which comprises reacting abietic acid, dehydroabietic acid, dihydroabietic acid or tetrahydroabietic acid or a reactive derivative thereof with an amine of the following formula:HNRR'wherein R and R' are each hydrogen, a straight chain or branched alkyl group having 3 to 15 carbon atoms, a lower alkenyl group, a cycloalkyl group, a phenyl group, a phenylalkyl group and a phenylalkyl group having a lower alkyl group at the .alpha.-position, with the proviso that such amines where both R and R' are hydrogen or where one of R and R' is hydrogen and the other is phenyl are excluded.The invention further comprises the resulting abietamide derivative reaction products, compositions containing effective blood serum cholesterol-reducing amounts of said abietamide derivatives and their use as anti-arteriosclerotic agents.
    Type: Grant
    Filed: May 12, 1975
    Date of Patent: July 1, 1980
    Inventors: Hiromu Murai, Katsuya Ohata, Hiroshi Enomoto, Kenji Sempuku, Koji Kitaguchi, Yukio Fujita, Yoshiaki Yoshikuni, Kohei Kura, Katsuhide Saito, Tamiki Mori, Yasuo Yasutomi
  • Patent number: 4112218
    Abstract: Sterol glycosides are isolated from sterol glycoside-containing plant material by heating the material in alkaline lower alkanol at elevated temperatures in the presence of an alkali metal carbonate, bicarbonate or nitrate to effect formation and precipitation of a complex which is then isolated.
    Type: Grant
    Filed: December 2, 1976
    Date of Patent: September 5, 1978
    Assignee: Nippon Shinyaku Co., Ltd.
    Inventors: Sho Inoue, Akira Sano, Koji Kitaguchi
  • Patent number: 4031303
    Abstract: Steryl-6-0-palmitoyl-.beta.-D-glucosides are anti-inflammatory agents. The compounds, of which .beta.-sitosteryl-6-0-palmitoyl-.beta.-D-glucoside is a representative embodiment, are prepared through the reaction of a steryl-6-0-sulfonyl-.beta.-D-glucoside with an alkali metal salt of palmitic acid.
    Type: Grant
    Filed: August 8, 1975
    Date of Patent: June 21, 1977
    Assignee: Nippon Shinyaku Co., Ltd.
    Inventors: Hiromu Murai, Koji Kitaguchi, Tatsuo Suminokura, Akira Sano, Masahiro Kise, Masahiko Kitano, Toshio Tomita
  • Patent number: 4024280
    Abstract: Process for the preparation of abietanilides which comprises reacting abietic acid, dihydroabietic acid, tetrahydroabietic acid or a reactive derivative thereof with aniline and the products thereby produced, compositions containing the same for reducing blood serum cholesterol and method of use of such compositions.
    Type: Grant
    Filed: May 12, 1975
    Date of Patent: May 17, 1977
    Assignee: Nippon Shinyaku Co., Ltd.
    Inventors: Hiromu Murai, Katsuya Ohata, Hiroshi Enomoto, Kenji Sempuku, Koji Kitaguchi, Yukio Fujita, Yoshiaki Yoshikuni, Kohei Kura, Katsuhide Saito, Tamiki Mori, Yasuo Yasutomi
  • Patent number: 4009206
    Abstract: Substituted N-phenyl and N-benzyl abietamide derivatives, including the dehydro-, dihydro-, and tetrahydroabietamide derivatives, are cholesterol lowering agents. The abietamide derivatives, of which N-(2,6-dimethylphenyl)-.DELTA..sup.8 -dihydroabietamide is a typical example, are produced by the reaction of abietic acid, dehydroabietic acid, dihydroabietic acid, tetrahydroabietic acid and/or active derivatives thereof with a substituted aniline or benzylamine.
    Type: Grant
    Filed: August 13, 1975
    Date of Patent: February 22, 1977
    Inventors: Hiromu Murai, Katsuya Ohata, Hiroshi Enomoto, Kenji Sempuku, Koji Kitaguchi, Yukio Fujita, Yoshiaki Yoshikuni, Kohei Kura, Katsahide Saito, Tamiki Mori, Yasuo Yasutomi
  • Patent number: 3991186
    Abstract: Steryl-6-O-palnitoyl and -2,3,4,6-O-tetrapalmitoyl-.beta.-D-glucosides are anti-inflammatory agents. The compounds, of which .beta.-sitosteryl-2,3,4,6-O-tetrapalmitoyl-.beta.-D-glucoside is a representative embodiment, are prepared through the reaction of a steryl-.beta.-D-glucoside with a lower alkyl ester of palmitic acid in the presence of a basic catalyst.
    Type: Grant
    Filed: August 8, 1975
    Date of Patent: November 9, 1976
    Assignee: Nippon Shinyaku Co., Ltd.
    Inventors: Hiromu Murai, Koji Kitaguchi, Tatsuo Suminokura, Akira Sano, Massahiro Kise, Masahiko Kitano, Toshio Tomita