Patents by Inventor Koji Machiya

Koji Machiya has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Production Method of Optically Active Cyclohexane Ether Compounds
    Publication number: 20090005576
    Abstract: The present invention relates to an industrial synthetic method of an optically active cyclohexane ether compound (IIIa) or a salt thereof, which is useful as a pharmaceutical agent, and an intermediate useful for the production method of the present invention. The production method of the present invention is as shown below: wherein each symbol is as defined in the specification. According to the production method of the present invention, efficient and stable supply of an optically active cyclohexane ether compound (IIIa) in a high yield at a lower cost can be afforded. Therefore, an optically active cyclohexane ether compound (IIIa) extremely useful as a pharmaceutical agent can be provided by an industrially highly advantageous method.
    Type: Application
    Filed: January 12, 2006
    Publication date: January 1, 2009
    Applicant: Astellas Pharma Inc.
    Inventors: Koji Machiya, Kazuo Ike, Masaru Watanabe, Toshitaka Yoshino, Takumi Okamoto, Yasuhiro Morinaga, Shoji Mizobata
  • Processes for producing pyridoindole derivatives
    Patent number: 6013653
    Abstract: A process for producing pyridiondole derivatives represented by general formula (III) or their salts (wherein R.sup.1 represents hydrogen, lower alkyl or lower alkenyl; R.sup.2 represents hydrogen, lower alkyl or halogeno; and R.sup.3 represents optionally substituted imidazolyl), which comprises reacting a compound represented by general formula (I) or its salt (wherein R.sup.1 and R.sup.2 are each as defined above) with a compound represented by general formula (II) or its salt (wherein R.sup.3.sub.a represents optionally substituted imidazolyl having an imino protecting group; and X represents halogeno), followed by a reaction for eliminating the imino protecting group); and a process for producing optically active pyridoindole derivatives represented by general formula (IV) or their salts: which comprises reacting a racemic mixture of the pyridoindole derivative represent by formula (III) or its salt with (1R)-(-)-10-camphorsulfonic acid.
    Type: Grant
    Filed: April 21, 1998
    Date of Patent: January 11, 2000
    Assignee: Fujisawa Pharmaceuticals Co., Ltd.
    Inventors: Kooji Kagara, Nobutaka Kawai, Takashi Nakamura, Shigeru Ieda, Koji Machiya, Atsushi Ohigashi
  • Intermediate for synthesis and production of amino acid derivative
    Patent number: 5523410
    Abstract: The present invention relates to synthetic intermediates useful for preparing amino acid derivatives possessing renin-inhibitory activity, and to processes for preparing the amino acid derivatives using the synthetic intermediates.
    Type: Grant
    Filed: January 3, 1995
    Date of Patent: June 4, 1996
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Kooji Kagara, Nobutaka Kawai, Koji Machiya, Tetsuo Furutera, Takashi Nakamura, Hiroki Omori
  • Process for producing an aliphatic amide and salts thereof
    Patent number: 5254733
    Abstract: The present invention relates to a process for producing (.+-.)-(E)-4-ethyl-2-[E-hydroxyimino]-5-nitro-3-hexenamide.
    Type: Grant
    Filed: October 15, 1991
    Date of Patent: October 19, 1993
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Kooji Kagara, Nobutaka Kawai, Koji Machiya, Kiyoaki Takasuka