Abstract: An acoustic conversion device includes: a driving unit including a pair of magnets disposed so as to face each other, a yoke to which the pair of magnets are attached, a coil to which driving current is supplied, a vibrating portion which vibrates when driving current is supplied to the coil, and an armature disposed between the pair of magnets with the vibrating portion being passed through the coil; and a diaphragm unit including a diaphragm, and a beam portion for propagating the vibration of the vibrating portion to the diaphragm; with a coil attachment portion to which the coil is attached, located in a state in parallel with the vibrating portion, being provided to the armature.

Abstract: A take-up machine is provided. Each of upper and lower conveying devices has an endless rotating body and a plurality of take-up pads provided on the surface of the endless rotating body. The take-up machine is configured to pinch a top face and a bottom face of a resin-molded article with the take-up pads of the upper and lower conveying devices to take up the resin-molded article. The take-up machine is installed along an extrusion line of a resin extruder. In a lateral direction orthogonal to an extrusion line, a length of each of the take-up pads is multiple times a length of the resin-molded article to be taken up. Each of the take-up pads has a plurality of supporting potions which are arranged in the lateral direction and capable of supporting resin-molded articles with different shapes. The upper and lower conveying devices are movable in the lateral direction so as to make one of the supporting portions coincide with the extrusion line.

Abstract: A startup control method of a resin extruder is provided. The resin extruder extrudes supplied resin material to a die as molten resin by rotating a screw. The resin material is supplied with a low supply amount which is smaller than a target supply amount and the screw is rotated at a low rotational frequency which is smaller than a target rotational frequency when starting the resin extruder. A supply amount of the resin material and a rotational frequency of the screw are gradually increased. After elapse of a set startup time, the supply amount of the resin material is brought into a target supply amount and the rotational frequency of the screw is brought into a target rotational frequency.

Abstract: A sizing device is installed on a downstream side in an extrusion direction of a die. A table having two sizing unit attachment portions which are adjacent to each other in a lateral direction orthogonal to the extrusion direction. The table is provided at a device body so as to be laterally movable between a first position where one of the two sizing unit attachment portions is at a production position and the other of the two sizing unit attachment portions is at a standby position, and a second position where the other of the two sizing unit attachment portions is at the production position and the one of the two sizing unit attachment portions is at the standby position. A sizing unit for production configured to perform cooling and sizing in practice is detachably attached to one of the two sizing unit attachment portions at the production position to coincide with an extrusion line.

Abstract: An extrusion molding method of a resin-molded article is provided. A resin extrusion molding apparatus includes an extruder, a die, a sizing device, a take-up device and a cutting machine. During the resin-molded article is extrusion-molded, a replacement die is made to stand by at a standby position laterally adjacent to the die and a replacement sizing unit is made to stand by at a standby position laterally adjacent to a sizing unit which coincides with an extrusion line of the sizing device. After the resin extrusion molding apparatus is stopped, the die is detached from the extruder and the replacement die is moved to and attached to the extruder, and the sizing unit is moved to a position laterally deviated from the extrusion line and the replacement sizing unit is moved to a position which coincides with the extrusion line. Upper and lower endless rotary bodies of the take-up device are laterally moved to make one of a plurality of supporting faces of pads coincide with the extrusion line.

Abstract: A particle beam treatment apparatus and an irradiation nozzle apparatus achieve a beam with a small diameter by a beam scanning irradiation method, and ensure a space for installation of a beam transport chamber in the irradiation nozzle apparatus. An X-ray tube is located outside the scanning type irradiation nozzle apparatus that includes scanning magnets, while an X-ray tube is located in an irradiation nozzle apparatus in a conventional structure. An X-ray detector is located inside the irradiation nozzle apparatus. The thickness of the X-ray detector in the direction of a beam axis is smaller and the structure thereof is simpler than that of the X-ray tube. This makes it possible to ensure the space for installation of the beam transport chamber in the irradiation nozzle apparatus and to increase the length of the beam transport chamber that is included in the irradiation nozzle apparatus.

Abstract: A beam extraction process (interruption and restart) is appropriately performed when a failure occurs during irradiation of a spot group. A charged particle irradiation system includes a synchrotron 12 and a scanning irradiation unit 15 that scans an ion beam extracted from the synchrotron over a subject. The extraction of the ion beam from the synchrotron is stopped on the basis of a beam extraction stop command. Scanning magnets 5A and 5B are controlled to change a point (spot) to be irradiated with the ion beam, while the extraction of the ion beam is stopped. The extraction of the ion beam from the synchrotron is restarted after the change of the spot to be irradiated. When a relatively minor failure in which continuous irradiation would be possible occurs during irradiation of a certain spot with the beam, the extraction of the beam is not immediately stopped.

Abstract: A charged particle beam irradiation system and a charged particle beam extraction method which can prevent erroneous irradiation of a charged particle beam in the direction of advance of the charged particle beam. The system and method are featured in stopping supply of an ion beam to one or more of a plurality of angle zones in each of which a target dose is attained, the angle zones being formed by dividing an RMW in a rotating direction thereof, and in allowing the supply of the ion beam to one or more other angle zones in each of which a target dose is not yet attained. The invention can easily adjust beam doses at various positions in an affected part of the patient body in the direction of advance of the ion beam, and can greatly reduce the probability of erroneous irradiation that the beam dose becomes excessive or deficient at the various positions within the affected part of the patient body in the direction of advance of the ion beam.

Abstract: Provision of a stabilized crystal of 6-(3-chloro-2-fluorobenzyl)-1-[(S)-1-hydroxymethyl-2-methylpropyl]-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (compound A). A crystal of compound A, which shows a particular X-ray powder diffraction pattern of a characteristic diffraction peaks at diffraction angles 2?(°) as measured by X-ray powder diffractometry.

Abstract: A charged particle beam extraction system and method capable of shortening the irradiation time and increasing the number of patients treatable per unit time. The charged particle beam extraction system comprises a synchrotron for cyclically performing patterned operation including four steps of introducing, accelerating, extracting and decelerating an ion beam, an on/off switch for opening or closing connection between an RF knockout electrode and an RF power supply for applying RF power to the RF knockout electrode, and a timing controller for controlling on/off-timing of the on/off switch such that when extraction of the ion beam is stopped at least once during the extraction step of the synchrotron, an amount of the ion beam extracted from the synchrotron in one cycle is held substantially at a setting value.

Abstract: To ensure irradiation accuracy and safety, even when an irradiation device employing a different irradiation method is used, disclosed is herein a charged particle beam irradiation apparatus that irradiates an irradiation target with charged particle beams includes: a charged particle beam generator for generating the charged particle beams; a passive scattering irradiation device and a scanning irradiation device, both for irradiating the irradiation target with the charged particle beams; a beam transport system for transporting the charged particles beam extracted from the charged particle beam generator, to selected one of the two irradiation devices; and a central controller that modifies operating parameters on the charged particle beam generator, according to the irradiation method adopted for the selected irradiation device.

Abstract: To ensure irradiation accuracy and safety, even when an irradiation device employing a different irradiation method is used, disclosed is herein a charged particle beam irradiation apparatus that irradiates an irradiation target with charged particle beams includes: a charged particle beam generator for generating the charged particle beams; a passive scattering irradiation device and a scanning irradiation device, both for irradiating the irradiation target with the charged particle beams; a beam transport system for transporting the charged particles beam extracted from the charged particle beam generator, to selected one of the two irradiation devices; and a central controller that modifies operating parameters on the charged particle beam generator, according to the irradiation method adopted for the selected irradiation device.

Abstract: The present invention provides a compound useful as a synthetic intermediate for an anti-HIV agent having an integrase inhibitory activity, a production method thereof, and a production method of an anti-HIV agent using the synthetic intermediate. Specifically, the present invention provides, for example, compounds represented by the formulas (6), (7-1), (7-2) and (8): wherein R is a fluorine atom or a methoxy group, R1 is a C1-C4 alkyl group, R2 is a hydroxyl-protecting group, and X2 is a halogen atom, a production method thereof, and a production method of an anti-HIV agent using the synthetic intermediate.

Abstract: Provision of a stabilized crystal of 6-(3-chloro-2-fluorobenzyl)-1-[(S)-1-hydroxymethyl-2-methylpropyl]-7-methoxy-4-oxo-1, 4-dihydroquinoline-3-carboxylic acid (compound A). A crystal of compound A, which shows a particular X-ray powder diffraction pattern of a characteristic diffraction peaks at diffraction angles 2?(°) as measured by X-ray powder diffractmetry.

Abstract: A charged particle beam extraction system and method capable of shortening the irradiation time and increasing the number of patients treatable per unit time. The charged particle beam extraction system comprises a synchrotron for cyclically performing patterned operation including four steps of introducing, accelerating, extracting and decelerating an ion beam, an on/off switch for opening or closing connection between an RF knockout electrode and an RF power supply for applying RF power to the RF knockout electrode, and a timing controller for controlling on/off-timing of the on/off switch such that when extraction of the ion beam is stopped at least once during the extraction step of the synchrotron, an amount of the ion beam extracted from the synchrotron in one cycle is held substantially at a setting value.

Abstract: A particle beam irradiation apparatus includes a synchrotron, two scanning electromagnets, a beam delivery apparatus for outputting an ion beam extracted from the synchrotron, and an accelerator and transport system controller, and a scanning controller. These controllers stop the output of the ion beam from the beam delivery apparatus; in a state where the output of the ion beam is stopped, change the irradiation position of the ion beam by controlling the scanning electromagnets; and after this change, control the scanning electromagnets to start the output of the ion beam from the beam delivery apparatus and to perform irradiations of the ion beam to at least one irradiation position a plurality of times based on treatment planning information.

Abstract: The present invention provides a compound useful as a synthetic intermediate for an anti-HIV agent having an integrase inhibitory activity, and a production method thereof, and a production method of an anti-HIV agent using the synthetic intermediate. Specifically, for example, a compound represented by the formula (2?): wherein R is a fluorine atom or a methoxy group, and R400 is a hydrogen atom or a C1-C4 alkyl group, or a salt thereof, and a production method thereof, and a production method of an anti-HIV agent using the synthetic intermediate.

Abstract: Particle beam irradiation equipment and a method of adjusting irradiation nozzle, which can ensure a long range and high dose uniformity at any field size are provided. The particle beam irradiation equipment comprises charged particle beam generation equipment and an irradiation nozzle for irradiating a charged particle beam extracted from the charged particle beam generation equipment to an irradiation target. The irradiation nozzle comprises a first scatterer device including a first scatterer for spreading out the charged particle beam into a Gaussian-like distribution, and multiple stages of second scatterer devices including second scatterers for producing a uniform intensity distribution of the charged particle beam having been spread out into a Gaussian-like distribution by the first scatterer.

Abstract: A particle therapy system capable of confirming energy of an accelerated charged particle beam before the charged particle beam is irradiated to an irradiation target. A beam position monitor is disposed in a synchrotron, and a cavity voltage monitor is associated with an RF cavity for acceleration. An ion beam orbiting within the synchrotron is accelerated with application of an RF voltage applied to the RF cavity and is extracted from the synchrotron with application of an RF voltage applied to an RF knockout electrode. Based on a cavity voltage signal detected by the cavity voltage monitor, a frequency counter measures the frequency of the RF voltage applied to the RF cavity. Based on a voltage detected by the beam position monitor, a beam signal processing unit measures the position of a beam orbit.

Abstract: A particle beam irradiation apparatus includes a synchrotron, two scanning electromagnets, an beam delivery apparatus for outputting an ion beam extracted from the synchrotron, and an accelerator and transport system controller, and a scanning controller. These controllers stop the output of the ion beam from the beam delivery apparatus; in a state where the output of the ion beam is stopped, change the irradiation position of the ion beam by controlling the scanning electromagnets; and after this change, control the scanning electromagnets to start the output of the ion beam from the beam delivery apparatus and to perform irradiations of the ion beam to at least one irradiation position a plurality of times based on treatment planning information.