Abstract: An object of the present invention is to find a novel pharmaceutical that has an excellent tryptophanase inhibitory effect and suppresses worsening of renal function to preserve the kidney by reducing production of indoxyl sulfate in the blood. The present invention provides a pharmaceutical composition containing, as an active ingredient, a compound represented by the following formula, or a pharmacologically acceptable salt thereof: wherein R1 and R2 are the same or different, and represent a C1-C6 alkyl group or the like, and Ar represents an optionally substituted phenyl group or an optionally substituted thienyl group.

Abstract: An endoscope system according to the present invention includes: a second illumination unit that emits second illumination light; a first illumination unit that emits, simultaneously with the second illumination light, first illumination light that is light of a different wavelength band from the second illumination light and is for imaging two sets of image information about a subject different depths; an imaging unit that simultaneously images a first illumination image of the subject illuminated with the first illumination light and a second illumination image of the subject illuminated with the second illumination light; a separation processing unit that separates the two sets of image information from the first illumination image; and a separated-image creating unit that processes the second illumination image using the two sets of image information to create separated images.

Abstract: A light treatment system includes: a probe configured to be inserted into a bladder, the probe including an optical fiber configured to propagate light, and a light emitter that is provided at a distal end of the optical fiber, the light emitter being configured to emit the light; and a balloon catheter into which the probe is inserted, the balloon catheter being configured to be inserted into the bladder, the balloon catheter including a distal end portion that is to be dilated in the bladder, a wall configured to divide inside of the distal end portion into two regions, and a reflector configured to reflect the light emitted by the light emitter, the reflector being provided on a surface of the wall, the surface facing a region of the two regions, the region being where the light emitter is positioned.

Abstract: A light treatment system includes: a probe configured to be inserted into a body cavity, the probe including an optical fiber configured to propagate light, and a light emitter that is provided at a distal end of the optical fiber, the emitter being configured to emit the light; a balloon catheter into which the probe is inserted, the balloon catheter including a distal end portion that is to be inserted into the body cavity and that is to be dilated by being supplied with a liquid including air bubbles; and an air bubble generator configured to generate the air bubbles to be included in the liquid and change a property of the air bubbles.

Abstract: Diffusion of a group III material into an Si substrate is suppressed during the time when a group III nitride semiconductor layer is grown on the Si substrate, with an AlN buffer layer being interposed therebetween. A method for manufacturing a group III nitride semiconductor substrate comprises: a step for growing a first AlN buffer layer on an Si substrate; a step for growing a second AlN buffer layer on the first AlN buffer layer at a temperature higher than a growth temperature of the first AlN buffer layer; and a step for growing a group III nitride semiconductor layer on the second AlN buffer layer. The growth temperature of the first AlN buffer layer is 400-600° C.

Abstract: There is provided a digital micrometer suitable for measuring an object to be measured that is a strong magnet. A digital micrometer includes a main-body frame, a spindle, a thimble part, and a displacement detector that detects displacement of the spindle. The main-body frame includes an U-shaped frame part, and a spindle holding part provided on the other end side of the U-shaped frame part and having a length in a direction away from an anvil. The spindle is held by a spindle holding part, provided to be movable forward and backward in an axial direction with respect to the anvil, and includes a contactor on one end face. The main-body frame and the spindle are formed of a non-magnetic material.

Abstract: An endoscope system includes: an illumination portion that includes a light source and that is configured to radiate an illumination light beam having a spatially nonuniform intensity distribution onto an imaging subject; a first imager and a second imager disposed at positions that are different from each other and configured to respectively acquire a first illumination image and a second illumination image of the imaging subject being illuminated with the illumination light beam; and at least one processor configured to: create a first deep-layer image and a first surface-layer image from the first illumination image and create a second deep-layer image and a second surface-layer image from the second illumination image; and create a combined deep-layer image by combining the first deep-layer image and the second deep-layer image on the basis of pixel values of the first and second surface-layer images.

Abstract: An object of the present invention is to find a novel pharmaceutical that has an excellent tryptophanase inhibitory effect, and suppresses worsening of renal function to preserve the kidney by reducing production of indoxyl sulfate in the blood. The present invention provides a pharmaceutical composition containing, as an active ingredient, a compound represented by the following formula, or a pharmacologically acceptable salt thereof: wherein R1 and R2 are the same or different, and represent a C1-C6 alkyl group or the like, and Ar represents an optionally substituted phenyl group or an optionally substituted thienyl group.

Abstract: An endoscope system according to the present invention includes: an illumination unit that radiates illumination light onto a subject, the illumination light having a spatially non-uniform intensity distribution including a light section and a dark section in a beam cross section orthogonal to an optical axis; an imaging unit that images an illumination image of the subject irradiated with the illumination light; and a separation processor that generates two separate images from the illumination image. Among intensity values of pixels within the illumination image respectively corresponding to the light section, the dark section, and a section having intermediate intensity between the light section and the dark section, the separation processor generates the two separate images based on at least two of the intensity values.

Abstract: An object of the present invention is to find a novel pharmaceutical that has an excellent tryptophanase inhibitory effect, and suppresses worsening of renal function to preserve the kidney by reducing production of indoxyl sulfate in the blood. Provided is a pharmaceutical composition containing, as an active ingredient, a compound represented by formula (I) or a pharmacologically acceptable salt thereof. In the formula (I), R1 and R2 are the same or different, and represent a C1-C6 alkyl group, a halogeno C1-C6 alkyl group or a C3-C6 cycloalkyl group; n represents 0, 1 or 2; each X represents a C1-C6 alkyl group, a C3-C6 cycloalkyl group, a halogen atom or the like; and Y represents a hydrogen atom, a C1-C6 alkoxy group, a C3-C6 cycloalkoxy group or a halogeno C1-C6 alkoxy group.

Abstract: An endoscope system of the present invention includes: a first illumination unit that emits first illumination light for imaging two sets of image information about a subject at different depths; a second illumination unit that emits second illumination light having a wide band covering a visible band from a position different from the position of the first illumination light; an imaging unit that images a first illumination image and a second illumination image of the subject that is illuminated with the first illumination light and the second illumination light; a separation processing unit that separates the two sets of image information from the first illumination image; and a separated-image generating unit that generates two separated images by processing the second illumination image using the two sets of image information.

Abstract: An interference fringe generating optical system generates an interference fringe, and a magnifying optical system magnifies the interference fringe and projects the interference fringe on an object surface. The magnifying optical system includes an incident-side lens group on the side where a light beam forming the interference fringe is incident and an exit-side lens group on the side where the light beam is emitted and the interference fringe is projected towards the object surface. The expression f1/f2>3 holds, where f1 is the focal length of the incident-side lens group, and f2 is the focal length of the exit-side lens group. The incident-side and exit-side lens groups each have a positive refractive power. The expression xd/(f1+f2)<2 is satisfied, where xd is the distance from the exit-side principal point of the incident-side lens group to the incident-side principal point of the exit-side lens group.

Abstract: A manufacturing method for a group III nitride semiconductor substrate is provided with a first step of forming a second group III nitride semiconductor layer on a substrate; a second step of forming a protective layer on the second group III nitride semiconductor layer; a third step of selectively forming pits on dislocation portions of the second group III nitride semiconductor layer by gas-phase etching applied to the protective layer and the second group III nitride semiconductor layer; and a fourth step of forming a third group III nitride semiconductor layer on the second group III nitride semiconductor layer and/or the remaining protective layer so as to allow the pits to remain.

Abstract: It is intended to provide a novel bisphosphonic acid compound or a salt thereof which shows a remarkable inhibitory effect on ectopic calcification, and a pharmaceutical composition comprising the same. The present invention provides a bisphosphonic acid compound represented by the following formula (1) or a pharmaceutically acceptable salt thereof: wherein represents a single bond or a double bond; A represents a saturated cyclic hydrocarbon or a saturated heterocyclic ring comprising a sulfur atom or an oxygen atom; and R1 and R2 each independently represent an alkyl group, an alkenyl group, an alkynyl group, an alkoxy group, an aryloxy group, a haloalkoxy group, a haloalkyl group, a halogen atom or a hydrogen atom.

Abstract: A measurement probe is configured to be detachably connected to a bio-optical measurement apparatus and includes: an illuminating fiber configured to irradiate body tissues with illumination light; light receiving fibers configured to receive return light of the illumination light reflected and/or scattered from the body tissues; an optical element configured to transmit the illumination light and the return light and to keep distances between the body tissues and distal ends of the illuminating fiber and the light receiving fibers, constant; and a contact detecting fiber configured to receive the return light to detect contact between a distal end face of the optical element and the body tissues, and detect the return light at a detection region on the distal end face through which the illumination light and the return light pass. The detection region is located outside an illumination region of the illuminating fiber.

Abstract: A constant-velocity universal joint including a generally cup-shaped outer joint member and an inner joint member that cooperate with each other to define first and second groove portions. A pinch angle by which a ball is pinched in the first groove portion is open toward an opening end of the outer joint member. A pinch angle by which the ball is pinched in the second groove is open toward a bottom wall of the outer joint member. An absolute value of the pinch angle in the first groove portion is larger than an absolute value of the pinch angle in the second groove portion in a reference state in which centerlines of the outer joint member and the inner joint member lie in a straight line.

Abstract: An endoscope system according to the present invention includes: a second illumination unit that emits second illumination light; a first illumination unit that emits, simultaneously with the second illumination light, first illumination light that is light of a different wavelength band from the second illumination light and is for imaging two sets of image information about a subject different depths; an imaging unit that simultaneously images a first illumination image of the subject illuminated with the first illumination light and a second illumination image of the subject illuminated with the second illumination light; a separation processing unit that separates the two sets of image information from the first illumination image; and a separated-image creating unit that processes the second illumination image using the two sets of image information to create separated images.

Abstract: An endoscope system according to the present invention includes: an illumination unit that radiates illumination light onto a subject, the illumination light having a spatially non-uniform intensity distribution including a light section and a dark section in a beam cross section orthogonal to an optical axis; an imaging unit that images an illumination image of the subject irradiated with the illumination light; and a separation processor that generates two separate images from the illumination image. Among intensity values of pixels within the illumination image respectively corresponding to the light section, the dark section, and a section having intermediate intensity between the light section and the dark section, the separation processor generates the two separate images based on at least two of the intensity values.

Abstract: An endoscope system of the present invention includes: a first illumination unit that emits first illumination light for imaging two sets of image information about a subject at different depths; a second illumination unit that emits second illumination light having a wide band covering a visible band from a position different from the position of the first illumination light; an imaging unit that images a first illumination image and a second illumination image of the subject that is illuminated with the first illumination light and the second illumination light; a separation processing unit that separates the two sets of image information from the first illumination image; and a separated-image generating unit that generates two separated images by processing the second illumination image using the two sets of image information.

Abstract: An object of the present invention is to find a novel pharmaceutical that has an excellent tryptophanase inhibitory effect, and suppresses worsening of renal function to preserve the kidney by reducing production of indoxyl sulfate in the blood. The present invention provides a pharmaceutical composition containing, as an active ingredient, a compound represented by the following formula, or a pharmacologically acceptable salt thereof: wherein R1 and R2 are the same or different, and represent a C1-C6 alkyl group or the like, and Ar represents an optionally substituted phenyl group or an optionally substituted thienyl group.