Abstract: There has been a demand in the marketplace for medicines, functional foods and so on which can relieve subjective symptoms of fatigue in persons having these subjective symptoms, and enabling the persons to have productive days. That is, an object of the present invention is to provide a composition for relieving subjective symptoms of fatigue. According to the present invention, a safe and effective composition for relieving subjective symptoms of fatigue which contains ornithine or a salt thereof as an active ingredient can be provided.

Abstract: An optically active form of the quinazolinone derivatives represented by the general formula (1): [wherein Y represents a phenyl group or C2-C7 alkyl group; E represents —CH? or nitrogen atom; and R represents a C1-C4 alkyl group and so on], or pharmaceutically acceptable salts thereof, has a selective antagonism for the M3 muscarinic receptor and depressant action on the frequency of rhythmic bladder contractions, and it is useful for the treatment of pollakiuria and urinary incontinence.

Abstract: Orally administered agents, foods and drinks, feeds, food additives or feed additives for preventing or treating a dry state of the skin accompanied by atopic dermatitis, xeroderma, chapped hand, chapped skin and the like are provided. The present invention can provide orally administered agents, foods and drinks, feeds, food additives or feed additives for preventing or treating a dry state of the skin, which comprise hydroxyproline, an N-acyl derivative of hydroxyproline, especially an N-acetyl derivative, an N-propionyl derivative, an N-butyryl derivative, an N-isobutyryl derivative, or a salt thereof as an active ingredient.

Abstract: It is desirable to provide a medicament or nutritional food to improve feeling of cold and to create fulfilling life for people who are suffering from feeling of cold. Specifically, one object of the present invention is to provide an, agent, a food and drink, or a food additive which can be used for improving feeling of cold. An agent, a food and drink, or a food additive for improving feeling of cold containing ornithine or a salt thereof as an active ingredient can be provided according to the present invention.

Abstract: It is desirable to provide a medicament and a nutritional food to improve skin conditions and to create fulfilling life for people who are not satisfactory about their skin conditions. Specifically, one object of the present invention is to provide an orally administered agent, a food and drink, or a food additive which can be used for improving skin condition. An orally administered agent, a food and drink, or a food additive for improving skin condition, comprising ornithine or a salt thereof as an active ingredient can be provided according to the present invention.

Abstract: The invention is a sterilizing apparatus that reads information from an information recording section provided in an endoscope, sets a sterilizing process condition for sterilizing the endoscope on the basis of the read information, and controls a sterilizing process in accordance with the sterilizing process condition that is set.

Abstract: An optically active form of the quinazolinone derivatives represented by the general formula (1): [wherein Y represents a phenyl group or C2-C7 alkyl group; E represents —CH? or nitrogen atom; and R represents a C1-C4 alkyl group and so on], or pharmaceutically acceptable salts thereof, has a selective antagonism for the M3 muscarinic receptor and depressant action on the frequency of rhythmic bladder contractions, and it is useful for the treatment of pollakiuria and urinary incontinence.

Abstract: A high temperature and pressure steam sterilization container for an endoscope, which contains the endoscope to perform a high temperature and pressure steam sterilization, is contained in a cleaner so that cleaning is possible in a state in which the endoscope is stored.

Abstract: A compound given by general formula (1): [wherein T represents oxygen or sulfur atom, Y represents alkyl, cycloalkyl group, etc., ring W represents benzene ring, etc., R1 and R2 represent independently hydrogen atom, lower alkyl group, etc., and R3 represents hydrogen atom, alkyl group, etc. Z represents a group given by formula: {wherein A1 and A2 represent independently hydrogen atom, alkyl group, etc. and G represents straight chain alkylene having 1-6 of the carbon number, etc.} or a group given by formula: {wherein n represents 0, 1 or 2, ring E represents 4-8 membered saturated heterocyclic ring containing nitrogen atom(s), and A3 represents hydrogen atom, alkyl group, etc.}], its prodrug or pharmaceutically acceptable salt thereof is an antagonist against muscarinic receptor that is useful as anticholinergic medicaments, and therefore it is useful as pollakiuria or urinary incontinence remedy.

Abstract: The present invention provides a therapeutic or preventing agent for diseases caused by a decrease in the expression level of Klotho protein in animals or humans and a feed or food and drink for the treatment or prevention of such diseases, which comprise ornithine or a salt thereof as an active ingredient. Also provided are a therapeutic or preventing agent for premature aging-like syndrome of homozygous klotho mutant animals and a feed for the treatment or prevention of the syndrome, which comprise ornithine or a salt thereof as an active ingredient, as well as a method for the treatment or prevention of premature aging-like syndrome of homozygous klotho mutant animals which comprises feeding the animals with the above feed.

Abstract: A process for preparing a pyridone derivative (4), which comprises reacting the compound (1) with a hypochlorite or a hypobromite or with lead tetraacetate to give the compound (2), and reacting the compound (2) with the compound (3). Said process is preferably especially from the standpoint of safety. wherein R1 is hydrogen, alkyl, substituted alkyl, etc.; Y1 is hydrogen, alky, substituted alky, etc.; Y2 and Y3 are indenpently hydrogen, halogen, etc.; and L is alkyl, substituted alkyl, etc.

Abstract: A process for preparing a pyridone derivative (4), which comprises reacting the compound (1) with a hypochlorite or a hypobromite or with lead tetraacetate to give the compound (2), and reacting the compound (2) with the compound (3). Said process is preferably especially from the standpoint of safety.

Abstract: A nourishing composition for animals according to the present invention comprises dextrin and at least one amino acid. When given to animals as a drink, the nourishing composition for animals can improve the nutritional conditions of the animals without causing browning in the aqueous solution.

Abstract: A process for preparing a pyridone derivative (4), which comprises reacting the compound (1) with a hypochlorite or a hypobromite or with lead tetraacetate to give the compound (2), and reacting the compound (2) with the compound (3). Said process is preferably especially from the standpoint of safety. wherein R1 is hydrogen, alkyl, substituted alkyl, etc.; Y1 is hydrogen, alky, substituted alky, etc.; Y2 and Y3 are indenpently hydrogen, halogen, etc.; and L is alkyl, substituted alky, etc.

Abstract: LDL receptor gene expression promoters containing a 1,2,4-triazine derivative of the formula (I): ##STR1## wherein R.sup.1 is optionally substituted phenyl or heterocycle; R.sup.2 is optionally substituted phenyl, naphthyl, aralkyl, 5- or 6-membered aromatic heterocycle, alkyl, or alkenyl; X is O, S or NR.sup.4 ; R.sup.3 is optionally substituted phenyl, naphthyl, aralkyl, 5- to 6-membered aromatic heterocycle, alkyl, cycloalkyl or alkenyl, provided that when X is NR.sup.4, then it may form an optionally substituted nitrogen-containing heterocycle, or a pharmaceutically acceptable salt thereof, which can increase the expression dose (the amount of mRNA) of LDL receptor gene, and thus increase the amount of LDL receptor, and reduce the serum cholesterol level, and are useful in the treatment of hyperlipidemia.

Abstract: Disclosed is a construction of a flexible tube, which is applied to an insertion section of an endoscope, adapted to be inserted into the body cavity. The flexible tube comprises a spiral tube formed by transforming a belt-shaped metal member into a spiral, a braid formed of fibers intertwined like a net, and fitted on the outer peripheral surface of the spiral tube, and a sheath covering the outer peripheral surface of the braid, and having a multilayer structure composed of inner and outer layers, at least for part of its length. The inner layer is a tube member which is formed of a high-polymer material, and is fitted on the outer peripheral surface of the braid. The outer layer is formed by applying a molten high-polymer material to the outer peripheral surface of the tube member, for cross-linking.

Abstract: A method of measuring the moving velocity of a linear object which is moving while vibrating, the method comprising the steps of illuminating the linear object with a flat laser beam having a width larger than the amplitude of vibration, the linear object moving in the direction of its length and vibrating perpendicular to the longitudinal direction; receiving the scattered light from the linear object by a photoelectric conversion device through a finite-sized elliptic or slit aperture disposed with the direction of its minor axis matching the direction of movement of the linear object; and cutting off the d.c. component of a speckle signal from the photoelectric conversion device, counting the number of zero-crossings per second of the resulting signal and converting the count value to a signal representing the longitudinal moving velocity of the linear object.

Abstract: A process for producing a substrate for optical recording medium (optical disk recording medium), which comprises coating at least one inner surface of a casting mold with a radiation-curable or thermosetting resin, curing the resin to form a coating film on the mold surface or surfaces, casting into the mold an epoxy resin composition comprising an alicyclic epoxy resin or a mixture of an alicyclic epoxy resin and an aromatic epoxy resin, an organic polybasic acid anhydride, a curing accelerator and an anti-discoloring (anti-oxidative) agent, curing the epoxy resin composition to transfer the coating film of the mold to the surface of the cured product of the epoxy resin composition, thereby forming a double or triple layer cast laminate. The above casting mold may have a mold-releasing film on the inner surfaces and the coating film may be formed on this mold-releasing film.