Abstract: A new car subscription service in which a user is entitled to use a new car by periodically paying a first flat-rate fee and a used vehicle subscription service in which a user is entitled to use a used vehicle by periodically paying a second flat-rate fee are provided. A proposal system includes an obtaining unit that obtains information on the first flat-rate fee for a model and a model year identical to those of a used vehicle and a processor that calculates the second flat-rate fee to be lower than the first flat-rate fee.

Abstract: A terminal apparatus includes a memory configured to store preference information on a user, a display, and a controller. The controller is configured to identify an image selected by the user as a target image, and for each candidate spot selected based on the preference information from among a plurality of spots, control the display to display, as a representative image for the candidate spot, a spot image determined to be similar to the target image by a similar image search from among a plurality of spot images associated with the candidate spot.

Abstract: A proposal system is a proposal system that proposes a method of using a used vehicle that was used in a flat-rate service in which a user is entitled to use a vehicle by making a periodic payment, and the proposal system includes a processor and an output unit. The processor calculates a first expected profit that will be obtained by selling the used vehicle, a second expected profit in a case in which the used vehicle is used in a subscription service, and a threshold value smaller than the first expected profit. When the second expected profit is larger than the threshold value, the processor has the output unit provide an output that the used vehicle be used in the flat-rate service.

Abstract: A new car subscription service in which a user is entitled to use a new car by periodically paying a first flat-rate fee and a used vehicle subscription service in which a user is entitled to use a used vehicle by periodically paying a second flat-rate fee are provided. A proposal system includes an obtaining unit that obtains information on the first flat-rate fee for a model and a model year identical to those of a used vehicle and a processor that calculates the second flat-rate fee to be lower than the first flat-rate fee.

Abstract: An adeno-associated virus (AAV) vector for inserting a desired nucleic acid into a nucleic acid in a cell, wherein the nucleic acid in the cell comprises a region consisting of a first nucleotide sequence and a region consisting of a second nucleotide sequence in order in a direction from a 5? end to a 3? end, wherein the vector comprises a first gRNA target sequence, a region consisting of a first nucleotide sequence, the desired nucleic acid, a region consisting of a second nucleotide sequence, a second gRNA target sequence, a cell-specific promoter, a sequence encoding a Cas9 nuclease, an RNA polymerase III promoter, a sequence encoding a first gRNA recognizing the first gRNA target sequence and a sequence encoding a second gRNA recognizing the second gRNA target sequence, wherein the vector yields a nucleic acid fragment comprising a region consisting of a first nucleotide sequence, the desired nucleic acid and the region consisting of the second nucleotide sequence by the Cas9 nuclease, wherein a first n

Abstract: The invention relates to the use of gene therapy vectors to improve vision by introducing into healthy rod photoreceptor cells of a patient suffering from cone photoreceptor dysfunction and/or degeneration a nucleic acid encoding a gene product that is light-sensitive and/or that modulates endogenous light-sensitive signalling in a photoreceptor cell, such that the range of light intensities to which the rod photoreceptor responds is extended and/or the speed at which the rod photoreceptor responds to light is increased

Abstract: A cleaning blade 1 includes an elastic body 11 that is a molded body of a rubber base material, and which has at least a surface treatment layer 12 in a portion of the elastic body 11, the portion coming into contact with an object to be contacted. The surface treatment layer 12 is formed by impregnating a surface portion of the elastic body 11 with a surface treatment liquid, which contains an isocyanate compound and an organic solvent, and curing the surface treatment liquid; the surface treatment layer 12 has an elastic modulus of 95 MPa or less; the elastic body 11 has an elastic modulus of from 20 MPa to 60 MPa (inclusive); and the difference between the elastic modulus of the surface treatment layer 12 and the elastic modulus of the elastic body 11 is 1 MPa or more.

Abstract: A cleaning blade 1 includes an elastic body 11 that is a molded body of a rubber base material, and which has at least a surface treatment layer 12 in a portion of the elastic body 11, the portion coming into contact with an object to be contacted. The surface treatment layer 12 is formed by impregnating a surface portion of the elastic body 11 with a surface treatment liquid, which contains an isocyanate compound and an organic solvent, and curing the surface treatment liquid; the surface treatment layer 12 has an elastic modulus of 95 MPa or less; the elastic body 11 has an elastic modulus of from 20 MPa to 60 MPa (inclusive); and the difference between the elastic modulus of the surface treatment layer 12 and the elastic modulus of the elastic body 11 is 1 MPa or more.

Abstract: The invention relates to the use of gene therapy vectors to improve vision by introducing into healthy rod photoreceptor cells of a patient suffering from cone photoreceptor dysfunction and/or degeneration a nucleic acid encoding a gene product that is light-sensitive and/or that modulates endogenous light-sensitive signaling in a photoreceptor cell, such that the range of light intensities to which the rod photoreceptor responds is extended and/or the speed at which the rod photoreceptor responds to light is increased.

Abstract: There is provided a model that can evaluate properties of viscoelasticity and also rubber elasticity of an elastic material. A correlation equation between stress and strain that is calculated from: a correlation equation between stress, strain, elastic modulus and relaxation time, calculated based on a Maxwell model in which an elastic element and a viscous element are placed in series; and a correlation equation between strain and elastic modulus, including different moduli depending on properties, the correlation equation between stress and strain including different moduli depending on said properties as parameters is output as a stress-strain curve formula. There is one feature in finding a correlation between the strain and the elastic modulus, and this allows a large deformation behavior of an elastic material having properties of both rubber elasticity and viscoelasticity to be expressed with high quantitative characteristics on simulation.

Abstract: There is provided a model that can evaluate properties of viscoelasticity and also rubber elasticity of an elastic material. A correlation equation between stress and strain that is calculated from: a correlation equation between stress, strain, elastic modulus and relaxation time, calculated based on a Maxwell model in which an elastic element and a viscous element are placed in series; and a correlation equation between strain and elastic modulus, including different moduli depending on properties, the correlation equation between stress and strain including different moduli depending on said properties as parameters is output as a stress-strain curve formula. There is one feature in finding a correlation between the strain and the elastic modulus, and this allows a large deformation behavior of an elastic material having properties of both rubber elasticity and viscoelasticity to be expressed with high quantitative characteristics on simulation.