Patents by Inventor Koji Nomoto

Koji Nomoto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11834695
    Abstract: The present invention relates to a method for simply diagnosing the progress of disease condition of a Parkinson's disease patient. Provided are a method for determining Parkinson's disease using the number of one or more intestinal bacteria selected from the group consisting of Bifidobacterium, Bacteroides fragilis group, Lactobacillus brevis, and Lactobacillus plantarum subgroup and/or the total number of intestinal bacteria as a marker, and a method for determining Parkinson's disease using the blood LPS level and/or the blood LBP level of a Parkinson's disease patient as an indicator.
    Type: Grant
    Filed: May 17, 2018
    Date of Patent: December 5, 2023
    Assignees: KABUSHIKI KAISHA YAKULT HONSHA, NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY
    Inventors: Hirokazu Tsuji, Takashi Asahara, Koji Nomoto, Masaaki Hirayama, Kinji Ohno
  • Publication number: 20220316627
    Abstract: An easily polymerizable substance handling device is provided that can prevent generation of irregularities and steps between a pipeline and a cover member due to the cover member being installed at an opening part of the pipeline. A cover part 3 is formed to have a curved surface 3a on a side closer to inside of a pipeline 1. The shape of the surface 3a on the pipeline 1 side is preferably a concave shape when viewed from inside of the pipeline 1. The shape of the surface 3a of the cover part 3 on the pipeline 1 side is more preferably the shape of a curved surface having a curvature radius equal or approximate to that of the internal circumference of the pipeline 1. With this configuration, a polymer material is unlikely to be generated at the cover part 3 and around a gap 1b at an opening part 1a, and the frequency of cleaning can be reduced as compared to conventional cases.
    Type: Application
    Filed: March 24, 2022
    Publication date: October 6, 2022
    Inventors: Shingo NAKAOKA, Koji NOMOTO
  • Publication number: 20210010052
    Abstract: The present invention relates to a method for simply diagnosing the progress of disease condition of a Parkinson's disease patient. Provided are a method for determining Parkinson's disease using the number of one or more intestinal bacteria selected from the group consisting of Bifidobacterium, Bacteroides fragilis group, Lactobacillus brevis, and Lactobacillus plantarum subgroup and/or the total number of intestinal bacteria as a marker, and a method for determining Parkinson's disease using the blood LPS level and/or the blood LBP level of a Parkinson's disease patient as an indicator.
    Type: Application
    Filed: May 17, 2018
    Publication date: January 14, 2021
    Applicants: KABUSHIKI KAISHA YAKULT HONSHA, NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY
    Inventors: Hirokazu TSUJI, Takashi ASAHARA, Koji NOMOTO, Masaaki HIRAYAMA, Kinji OHNO
  • Patent number: 10752961
    Abstract: Disclosed herein is a method for determining whether a test subject has equol-producing ability or not. The method involves measuring equol-producing ability of a test subject, wherein an equol converting enzyme gene derived from enteric bacteria of the test subject is detected using three types of primer sets described herein as the primer sets a) to c).
    Type: Grant
    Filed: October 28, 2016
    Date of Patent: August 25, 2020
    Assignee: KABUSHIKI KAISHA YAKULT HONSHA
    Inventors: Hirokazu Tsuji, Kaoru Moriyama, Koji Nomoto
  • Patent number: 10174386
    Abstract: An object of the present invention is to provide a method of quantitating or detecting a microorganism, capable of detecting a live microorganism at high sensitivity and more precisely. A method of quantitating a microorganism of interest, using as an index the amount of rRNA of the microorganism of interest is provided.
    Type: Grant
    Filed: January 30, 2006
    Date of Patent: January 8, 2019
    Assignee: KABUSHIKI KAISHA YAKULT HONSHA
    Inventors: Hirokazu Tsuji, Kazunori Matsuda, Takashi Asahara, Koji Nomoto, Mayumi Kiwaki
  • Publication number: 20180312906
    Abstract: Disclosed herein is a method for determining whether a test subject has equol-producing ability or not. The method involves measuring equol-producing ability of a test subject, wherein an equol converting enzyme gene derived from enteric bacteria of the test subject is detected using three types of primer sets described herein as the primer sets a) to c).
    Type: Application
    Filed: October 28, 2016
    Publication date: November 1, 2018
    Applicant: KABUSHIKI KAISHA YAKULT HONSHA
    Inventors: Hirokazu TSUJI, Kaoru MORIYAMA, Koji NOMOTO
  • Publication number: 20170196917
    Abstract: An agent for the prevention and treatment of chlamydia infection containing Lactobacillus casei as an active ingredient which is an agent for the prevention and treatment of chlamydia infection that is highly safe and that can be administered over an extended period of time.
    Type: Application
    Filed: May 14, 2015
    Publication date: July 13, 2017
    Applicant: KABUSHIKI KAISHA YAKULT HONSHA
    Inventors: Takashi ASAHARA, Akira TAKAHASHI, Koji NOMOTO, Takashi KURAKAWA, Shoichi KADO, Norikatsu YUKI, Takuya TAKAHASHI
  • Patent number: 9080197
    Abstract: An object of the invention is to provide a medical drug, a food and drink having a role in regulating the concentration of equol in vivo and being capable of taking for a long time with high safety and provide a selective medium for a microorganism having conversion ability to equol and a method of detecting the same. Provided are an equol concentration-raising or reducing agent containing a carbohydrate as an active ingredient; use of a carbohydrate for producing the equol concentration-raising or reducing agent; a method of raising or reducing the concentration of equol by administrating a carbohydrate in an effective dose; a selective medium containing a carbohydrate for a microorganism having conversion ability to equol; and a method of detecting a microorganism having conversion ability to equol by use of the selective medium.
    Type: Grant
    Filed: November 2, 2006
    Date of Patent: July 14, 2015
    Assignee: KABUSHIKI KAISHA YAKULT HONSHA
    Inventors: Hirokazu Tsuji, Koji Nomoto, Hideyuki Akaza
  • Patent number: 8420073
    Abstract: The present invention is directed to a microorganism having an ability of converting daidzein to equol in 24 hours of 50% or higher; a food/beverage or pharmaceutical composition containing the microorganism; an equol production method employing the microorganism; and a nucleic acid fragment which can specifically detect the microorganism.
    Type: Grant
    Filed: February 25, 2010
    Date of Patent: April 16, 2013
    Assignee: Kabushiki Kaisha Yakult Honsha
    Inventors: Hirokazu Tsuji, Koji Nomoto, Kaoru Moriyama, Hideyuki Akaza
  • Publication number: 20110318309
    Abstract: The present invention is directed to a microorganism having an ability of converting daidzein to equol in 24 hours of 50% or higher; a food/beverage or pharmaceutical composition containing the microorganism; an equol production method employing the microorganism; and a nucleic acid fragment which can specifically detect the microorganism.
    Type: Application
    Filed: February 25, 2010
    Publication date: December 29, 2011
    Applicant: KABUSHIKI KAISHA YAKULT HONSHA
    Inventors: Hirokazu Tsuji, Koji Nomoto, Kaoru Moriyama, Hideyuki Akaza
  • Publication number: 20090253643
    Abstract: An object of the invention is to provide a medical drug, a food and drink having a role in regulating the concentration of equal in vivo and being capable of taking for a long time with high safety and provide a selective medium for a microorganism having conversion ability to equal and a method of detecting the same. Provided are an equal concentration-raising or reducing agent containing a carbohydrate as an active ingredient; use of a carbohydrate for producing the equal concentration-raising or reducing agent; a method of raising or reducing the concentration of equal by administrating a carbohydrate in an effective dose; a selective medium containing a carbohydrate for a microorganism having conversion ability to equal; and a method of detecting a microorganism having conversion ability to equal by use of the selective medium.
    Type: Application
    Filed: November 2, 2006
    Publication date: October 8, 2009
    Applicant: KABUSHIKI KAISHA YAKULT HONSHA
    Inventors: Hirokazu Tsuji, Koji Nomoto, Hideyuki Akaza
  • Publication number: 20090170078
    Abstract: An object of the present invention is to provide a method of quantitating or detecting a microorganism, capable of detecting a live microorganism at high sensitivity and more precisely. A method of quantitating a microorganism of interest, using as an index the amount of rRNA of the microorganism of interest is provided.
    Type: Application
    Filed: January 30, 2006
    Publication date: July 2, 2009
    Applicant: KABUSHIKI KAISHA YAKULT HONSHA
    Inventors: Hirokazu Tsuji, Kazunori Matsuda, Takashi Asahara, Koji Nomoto, Mayumi Kiwaki
  • Patent number: 5601999
    Abstract: An antitumor agent is provided by including, as an active ingredient, a polysaccharide-glycan complex obtained by treating a Gram-positive bacteria such as lactic acid bacteria and Bifidobacterium strains with a cell wall lytic enzyme produced by a bacterium belonging to the genus Achromobacter.The polysaccharide-glycan complex has no toxicity and causes no side effect. Being water-soluble, it is easily formulated into any arbitrary dose form, such as an injectable solution. It can easily be prepared from an easily available starting material.
    Type: Grant
    Filed: September 1, 1994
    Date of Patent: February 11, 1997
    Assignee: Kabushiki Kaisha Yakult Honsha
    Inventors: Takeshi Matsuzaki, Masato Nagaoka, Koji Nomoto, Shusuke Hashimoto, Teruo Yokokura