Abstract: An object of the present invention is to provide a microneedle array in which the stability of influenza vaccine during production is satisfactory and the utilization efficiency of the influenza vaccine is high, and a method of producing the same. According to the present invention, provided is a self-dissolving microneedle array including a sheet portion, and a plurality of needle portions which are present on an upper surface of the sheet portion, in which the needle portion contains a saccharide, influenza vaccine, a natural amino acid or a salt thereof, and a surfactant and the influenza vaccine is administered into a body by dissolution of the needle portions.

Abstract: An object of the present invention is to provide a micro-needle array unit that can be miniaturized and can sufficiently puncture the skin even in a case of being pressed by a finger.

Abstract: An object of the present invention is to provide a micro-needle array device that can have the needle part sufficiently dissolved. According to the present invention, there is provided a micro-needle array device including: a micro-needle array having a sheet part and a plurality of needle parts existing on the top face of the sheet part; and a pressing member for pressing a surface of the sheet part, the surface being on the opposite side of the surface having the needle parts, wherein the sheet part has a thickness of 0.1 to 0.6 mm, and an area A of a pressing face of the pressing member for pressing the sheet part of the micro-needle array and an area B of a region where the needle parts of the needle array exist, satisfy the formula: 0.3?A/B?0.75.

Abstract: An object of the present invention is to provide a method of producing a microneedle array that enables concentration of a drug at needle tips of the microneedle array. According to the present invention, provided is a method of producing a microneedle array, including a step of filling a hydrophobic mold with a drug-containing solution to form a needle tip, and a step of filling the mold including the formed needle tip with a liquid which contains a water-soluble polymer or disaccharides to form a needle base and a sheet, in which the drug-containing solution contains 0.01 mg/mL to 5 mg/mL of a surfactant.

Abstract: An object of the present invention is to provide a microneedle array which has strength of withstanding the impact at the time of puncture. According to the present invention, provided is a microneedle array including: a sheet; and a plurality of needles which are present on an upper surface of the sheet, in which the needles contain a water-soluble polymer, the sheet contains a water-soluble polymer, the sheet has a central portion, which is a region where the plurality of needles are formed, and an end portion, and an average film thickness of the end portion is smaller than an average film thickness of the central portion.

Abstract: An object of the present invention is to provide a microneedle array which is formed of a sheet portion and needles and is capable of achieving high drug efficacy. According to the present invention, provided is a microneedle array including: a sheet portion; and a plurality of needles present on an upper surface of the sheet portion, in which the needle contains a water-soluble polymer and a medicament, the water-soluble polymer occupies 50% by mass or greater of the total solid content of the needle, the water-soluble polymer and the medicament are present at a mass ratio of Formula 1, in a needle tip region which includes a needle tip of each needle and has a height corresponding to 20% of the total height of each needle, and the sheet portion contains a water-soluble polymer. water-soluble polymer:medicament=0.05 to 0.

Abstract: To provide a transdermal absorption sheet with which control of a dissolution rate and suppression of drug diffusion can be achieved, and a method of manufacturing the transdermal absorption sheet. A transdermal absorption sheet 100 is provided with a sheet portion 116, a plurality of frustum portions 114 that is disposed on the sheet portion 116, and needle portions 112 that are disposed on the frustum portions 114, each of the plurality of needle portions 112 includes a first layer 120 containing a drug and a second layer 122 not containing a drug, and at least one of the plurality of needle portions 112 contains an air bubble 124.

Abstract: An object is to provide a method of manufacturing a transdermal absorption sheet and a transdermal absorption sheet that can suppress generation of air bubbles. In the method of manufacturing the transdermal absorption sheet that includes a drug solution filling step, a drug solution drying step, a base solution filling step, a base solution drying step, and a peeling-off step in that order, each step of at least from the drug solution filling step to the base solution drying step is performed in an environment with a temperature of 1° C. to 10° C.

Abstract: To provide a transdermal absorption sheet with which control of a dissolution rate and suppression of drug diffusion can be achieved, and a method of manufacturing the transdermal absorption sheet. A transdermal absorption sheet 100 is provided with a sheet portion 116, a plurality of frustum portions 114 that is disposed on the sheet portion 116, and needle portions 112 that are disposed on the frustum portions 114, each of the plurality of needle portions 112 includes a first layer 120 containing a drug and a second layer 122 not containing a drug, and at least one of the plurality of needle portions 112 contains an air bubble 124.