Abstract: A light source device includes a first light source, a second light source, and a processor. The processor controls, based on spectrum setting information, an emitted light amount of the first light source and an emitted light amount of the second light source so that the emitted light amount of the first light source becomes larger than the emitted light amount of the second light source. The observation object includes a region of interest, a merkmal, and a peripheral portion. The spectrum setting information is set based on a merkmal observed ratio that is a ratio between a spectral reflectance in the merkmal and a spectral reflectance in the peripheral portion. A degree of disassociation of the merkmal observed ratio in the first wavelength region from 1 is greater than a degree of disassociation of the merkmal observed ratio in the second wavelength region from 1.

Abstract: Provided is a biological observation apparatus including irradiating portions that radiate illumination light onto biological tissue, an imaging portion that, of reflected light reflected at the biological tissue due to the illumination light radiated by the irradiating portions, captures reflected light in a wavelength band in which an absorption characteristic of ?-carotene is greater than an absorption characteristic of hemoglobin, thus acquiring a reflected-light image, and a display portion that displays the reflected-light image acquired by the imaging portion.

Abstract: Provided is a biological observation apparatus including: illuminating portions that irradiate biological tissue with illumination light including light in R, G, and B regions, respectively; an image acquisition portion that acquires image signals from reflected light of the illumination light coming from the biological tissue; narrow-band-light generating portions that are disposed in the illuminating portions or the image acquisition portion and that, in wavelength bands of the illumination light, generate two narrow-band beams for at least one of the R, G, and B wavelength bands constituting the illumination light, on either side of a central wavelength of that wavelength band; and an image-generating portion that generates an image on the basis of two or more types of the image signals obtained from the reflected light including two or more narrow bands acquired by the image acquisition portion.

Abstract: A fluorescence-spectrum-recording unit, a fluorescence-image-acquiring unit, and a fluorescent-dye-density-calculating unit are comprised, the calculating unit calculates the densities D1 to Dm of fluorescent dyes 1 to m in each of all the pixels and in all of the pixels with the following equation, and, when there exists a pixel in which one of the calculation values of these densities is smaller than 0, a set value larger than the calculation value smaller than 0 is substituted for the density the calculation value of which is smaller than 0 in the equation, and the densities of the other fluorescent dyes are recalculated, relative to the pixel: ( D ? ? 1 ? Dm ) = ( a ? ? 1 ? ( ? ? ? 1 ) … am ? ( ? ? ? 1 ) ? ? ? a ? ? 1 ? ( ? ? ? n ) … am ? ( ? ? ? n ) ) - 1 ? ( I all ? ( ? ? ? 1 ) ? I all ? ( ? ? ? n ) ) where a1 (?1) to am (?n) denote the coefficients for the flu

Abstract: A fluorescence observation apparatus including: a light source unit that simultaneously irradiates a subject with illumination light and excitation light having a partial wavelength band of the wavelength band of the illumination light; an objective lens unit that forms an image of reflected light reflected at the subject due to being irradiated with the illumination light and an image of fluorescence generated at the subject due to being irradiated with the excitation light; a single image capturing element that simultaneously acquires the images of reflected light and fluorescence; a filter that is disposed between the objective lens unit and the image capturing and that transmits the light, except the excitation light, to the image capturing element; and a light-adjusting unit that adjusts the output intensity of the illumination light and the output intensity of the excitation light from the light source unit independently of each other.

Abstract: A fluoroscopy apparatus includes a light-source configured to irradiate biological tissue with illumination light including excitation light; and a processor including hardware, wherein the processor is configured to implement: a reflected-light-image generating portion configured to generate a reflected-light-image of the biological tissue based on captured reflected light reflected from the biological tissue irradiated with the illumination light from the light-source; and a fluorescence-image generating portion configured to generate a fluorescence image based on captured fluorescence generated at the biological tissue due to irradiation thereof with the excitation light from the light-source, wherein the illumination light is visible light that does not include at least a portion of the wavelength region between 490 nm and 540 nm, and wherein the excitation light includes some wavelengths of the illumination light and generates fluorescence having a wavelength included in the at least a portion of the wav

Abstract: Provided is a biological observation apparatus including irradiating portions that radiate illumination light onto biological tissue, an imaging portion that, of reflected light reflected at the biological tissue due to the illumination light radiated by the irradiating portions, captures reflected light in a wavelength band in which an absorption characteristic of ?-carotene is greater than an absorption characteristic of hemoglobin, thus acquiring a reflected-light image, and a display portion that displays the reflected-light image acquired by the imaging portion.

Abstract: A spectral imaging apparatus includes a variable wavelength spectroscopic element changing a distance between surfaces of a pair of optical substrates opposite to each other to change a peak wavelength, a light splitting unit which splits light transmitted by the variable wavelength spectroscopic element into components in each of the predetermined wavelength ranges, and image-capturing units each of which captures only a spectral image formed by the components in each of the wavelength ranges into which the transmitted light is split by the light splitting unit, the wavelength ranges including the peak wavelengths respectively.

Abstract: An endoscope system includes an spouting portion spouting a fluorescent agent and a cleaning liquid, a light source portion emitting excitation light and irradiation light having different spectral characteristics, an optical system transmitting the excitation light or the irradiation light to the object, an image capture portion disposed in a section inserted into the coelom and picking up fluorescence and light having a different spectrum band that are emitted from the object, a spectroscopic portion disposed in an optical pass between the image capture portion and an end of the inserted section and restraining light having the same spectrum band as the excitation light from entering the image capture portion, and a control portion allowing the light source portion to emit excitation light at least once after the spouting portion spouts the fluorescent agent onto the object and before the spouting portion spouts the cleaning liquid.

Abstract: The number of aberrant crypt foci (ACF) can be readily counted without overlooking the existence of ACF to achieve reduced observation time. A fluorescence observation apparatus includes a light source unit inserted into a body cavity of a biological organism and emitting excitation light onto an inner wall of the body cavity; an image acquisition unit that acquires image information by acquiring an image of fluorescence generated when a fluorescent probe whose fluorescence characteristic changes by reacting with a molecule existing in an ACF formed in the inner wall of the body cavity is excited by the excitation light; a position control unit that moves the light source unit and the image acquisition unit relative to the inner wall of the body cavity; and a counting section that counts the number of fluorescence generation sites included in the image acquired by the image acquisition unit.

Abstract: A spectral imaging apparatus includes: a spectral transmittance variable element having a spectral transmittance characteristics such that a transmittance periodically varies with wavelength and being capable of changing the variation period, for converting light from an object under observation into light having a plurality of peak wavelengths; a light extracting device for extracting, from the light having a plurality of peak wavelengths, light for imaging that contains a peak wavelength proximate to a predetermined command wavelength designated by a user and light for calibration that contains a peak wavelength other than the peak wavelength proximate to the command wavelength; an image sensor for capturing an image of the object under observation formed of the light for imaging; a detector for detecting, from the light for calibration, the peak wavelength other than the peak wavelength proximate to the command wavelength; and a control unit including, an operation processing section that calculates the pe

Abstract: A fluorescence-spectrum-recording unit, a fluorescence-image-acquiring unit, and a fluorescent-dye-density-calculating unit are comprised, the calculating unit calculates the densities D1 to Dm of fluorescent dyes 1 to m in each of all the pixels and in all of the pixels with the following equation, and, when there exists a pixel in which one of the calculation values of these densities is smaller than 0, a set value larger than the calculation value smaller than 0 is substituted for the density the calculation value of which is smaller than 0 in the equation, and the densities of the other fluorescent dyes are recalculated, relative to the pixel: ( D ? ? 1 ? Dm ) = ( a ? ? 1 ? ( ? ? ? 1 ) … am ? ( ? ? ? 1 ) ? ? ? a ? ? 1 ? ( ? ? ? n ) … am ? ( ? ? ? n ) ) - 1 ? ( I all ? ( ? ? ? 1 ) ? I all ? ( ? ? ? n ) ) where a1 (?1) to am (?m) denote the coefficients for the fluor

Abstract: A fluorescence distribution image of each fluorescent agent can be acquired from a fluorescence image that has been captured in a mixed state so as to improve the diagnosability of cancer cells.

Abstract: Provided is a fluorescence endoscope system for observing fluorescence from a fluorochrome attached to or absorbed in biological tissue, including an excitation light source that emits excitation light that excites the fluorochrome; an image-acquisition section that acquires fluorescence emitted from the biological tissue when irradiated with the excitation light from the excitation light source; an autofluorescence signal setting section that sets an autofluorescence signal intensity to be emitted from the biological tissue when irradiated with the excitation light; and an image compensation section that compensates fluorescence image information acquired by the image-acquisition section on the basis of the autofluorescence signal intensity set by the autofluorescence signal setting section.

Abstract: To accurately obtain fluorescence intensity in a variable passband. Provided is a fluorescence observation apparatus including an excitation light source that emits excitation light; a Fabry-Perot resonator including a variable passband in which the wavelength of light that passes therethrough changes with changes in distance between the surfaces of optical members opposing each other with a distance therebetween, a fixed passband in which the wavelength of light that passes therethrough does not change irrespective of changes in the distance between the surfaces, and a transition band therebetween; an excitation-light cut filter that blocks passage of the excitation light; a band cut filter having a cut-off band including the transition band and not including the wavelength of the excitation light; and a photodetector that detects fluorescence that has passed through the Fabry-Perot resonator, the excitation-light cut filter, and the band cut filter.

Abstract: An endoscope system and an observation method using the same includes an agent dispensing portion for dispensing towards an acquisition object a fluorescent agent; a light source portion for emitting excitation light for exciting the fluorescent agent and irradiation light having different spectral characteristics from the excitation light; an optical system for transmitting the excitation light and the irradiation light towards the acquisition object; image-acquisition means, disposed at a portion that is inserted inside a body cavity and capable of acquiring fluorescence excited from the acquisition object by the excitation light, and light in a different wavelength band, which is excited from the acquisition object by the irradiation light; and control means for controlling the agent-dispensing means so that the acquisition object is irradiated with the irradiation light before the fluorescent agent is spouted out towards the acquisition object and for synchronizing at least the operation for spouting the

Abstract: To accurately obtain fluorescence intensity in a variable passband. Provided is a fluorescence observation apparatus including an excitation light source that emits excitation light; a Fabry-Perot resonator including a variable passband in which the wavelength of light that passes therethrough changes with changes in distance between the surfaces of optical members opposing each other with a distance therebetween, a fixed passband in which the wavelength of light that passes therethrough does not change irrespective of changes in the distance between the surfaces, and a transition band therebetween; an excitation-light cut filter that blocks passage of the excitation light; a band cut filter having a cut-off band including the transition band and not including the wavelength of the excitation light; and a photodetector that detects fluorescence that has passed through the Fabry-Perot resonator, the excitation-light cut filter, and the band cut filter.

Abstract: The number of ACF can be readily counted without overlooking the existence of ACF to achieve reduced observation time. A fluorescence observation apparatus includes a light source unit inserted into a body cavity of a biological organism and emitting excitation light onto an inner wall of the body cavity; an image acquisition unit that acquires image information by acquiring an image of fluorescence generated when a fluorescent probe whose fluorescence characteristic changes by reacting with a molecule existing in an ACF formed in the inner wall of the body cavity is excited by the excitation light; a position control unit that moves the light source unit and the image acquisition unit relative to the inner wall of the body cavity; and a counting section that counts the number of fluorescence generation sites included in the image acquired by the image acquisition unit.

Abstract: A spectral imaging apparatus includes: a spectral transmittance variable element having a spectral transmittance characteristics such that a transmittance periodically varies with wavelength and being capable of changing the variation period, for converting light from an object under observation into light having a plurality of peak wavelengths; a light extracting device for extracting, from the light having a plurality of peak wavelengths, light for imaging that contains a peak wavelength proximate to a predetermined command wavelength designated by a user and light for calibration that contains a peak wavelength other than the peak wavelength proximate to the command wavelength; an image sensor for capturing an image of the object under observation formed of the light for imaging; a detector for detecting, from the light for calibration, the peak wavelength other than the peak wavelength proximate to the command wavelength; and a control unit including, an operation processing section that calculates the pe

Abstract: The concentration distribution of a fluorescence dye capable of selectively staining normal tissue and abnormal tissue is accurately observed by eliminating the unevenness due to irregular distance from the distal end of an endoscope to an organism surface or the surface roughness of the organism.