Patents by Inventor Koko Sugawara

Koko Sugawara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds produced by a strain of Streptomyces exfoliatus
    Patent number: 5332574
    Abstract: Disclosed are active compounds BU-4726G-A and BU-4726G-B which contain a quinone chromophore and hydroquinone chromophore, respectively. The compounds are produced by fermentation of Streptomyces exfoliatus AA4510. The compounds possess antimicrobial, and K.sub.ATP channel blocking activities.
    Type: Grant
    Filed: February 11, 1993
    Date of Patent: July 26, 1994
    Assignee: Bristol-Myers Squibb Company
    Inventors: Koko Sugawara, Koji Tomita, Michael R. Kozlowski, Yosuke Sawada
  • BU-3292T antibiotics
    Patent number: 5114920
    Abstract: New antibiotics designated BU-3292T A and B are provided which exhibit antimicrobial activity and also inhibit the growth of tumors in experimental animal systems. BU-3292T A is produced by fermentation of Elytrosporangium sp. nov. (ATCC 53784) while the BU-3292T B compound is obtained by oxidation of BU-3292T A.
    Type: Grant
    Filed: September 14, 1988
    Date of Patent: May 19, 1992
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Koko Sugawara, Yuji Nishiyama, Koji Tomita, Masataka Konishi, Toshikazu Oki
  • BU-3862T antitumor antibiotic
    Patent number: 5093248
    Abstract: A new antitumor antibiotic designated herein as BU-3862T is produced by fermentation of Streptomyces hygroscopicus ATCC 53709. BU-3862T and its diacetyl and dihydro derivatives inhibit the growth of tumors in experimental animals.
    Type: Grant
    Filed: November 13, 1989
    Date of Patent: March 3, 1992
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Koko Sugawara, Masami Hatori, Hideo Kamei, Masataka Konishi, Toshikazu Oki, Koji Tomita
  • BU-4146T antibiotic
    Patent number: 5037836
    Abstract: A novel antibiotic designated BU-4146T is produced by fermentation of Streptomyces amphibiosporus strain R310-104 (ATCC-53964). The antibiotic possesses both antifungal and antitumor activity.
    Type: Grant
    Filed: July 23, 1990
    Date of Patent: August 6, 1991
    Assignee: Bristol-Myers Squibb Company
    Inventors: Masataka Konishi, Koko Sugawara, Masaru Ohbayashi, Takeo Miyaki
  • BU-4146T antibiotic
    Patent number: 5002959
    Abstract: A novel antibiotic designated BU-4146T is produced by fermentation of Streptomyces amphibiosporus strain R310-104 (ATCC-53964). The antibiotic possesses both antifungal and antitumor activity.
    Type: Grant
    Filed: December 11, 1989
    Date of Patent: March 26, 1991
    Assignee: Bristol-Myers Squibb Company
    Inventors: Masataka Konishi, Koko Sugawara, Masaru Ohbayashi, Takeo Miyaki
  • BU-3862T antitumor antibiotic
    Patent number: 4912133
    Abstract: A new antitumor antibiotic designated herein as BU-3862T is produced by fermentation of Streptomyces hygroscopicus ATCC 53709. BU-3862T and its diacetyl and dihydro derivatives inhibit the growth of tumors in experimental animals.
    Type: Grant
    Filed: March 7, 1988
    Date of Patent: March 27, 1990
    Assignee: Bristol-Myers Company
    Inventors: Koko Sugawara, Masami Hatori, Hideo Kamei, Masataka Konishi, Toshikazu Oki, Koji Tomita
  • Biologically pure culture of the microorganism Streptomycas tropolofaciens used for producing 3,7-dihydroxytropolone and antitumor use
    Patent number: 4883758
    Abstract: The compound 3,7-dihydroxytropolone having the formula ##STR1## is produced by fermentation of Streptomyces tropolofaciens and is found to inhibit the growth of mammalian tumors.
    Type: Grant
    Filed: January 6, 1989
    Date of Patent: November 28, 1989
    Assignee: Bristol-Myers Company
    Inventors: Hideo Kamei, Masaru Ohbayashi, Koji Tomita, Koko Sugawara, Masataka Konishi
  • Process for producing 3,7-dihydroxytropolone and antitumor use thereof
    Patent number: 4833079
    Abstract: The compound 3,7-dihydroxytropolone having the formula ##STR1## is produced by fermentation of Streptomyces tropolofaciens and is found to inhibit the growth of mammalian tumors.
    Type: Grant
    Filed: November 5, 1986
    Date of Patent: May 23, 1989
    Assignee: Bristol-Myers Company
    Inventors: Hideo Kamei, Masaru Ohbayashi, Koji Tomita, Koko Sugawara, Masataka Konishi
  • Process for preparing an antibiotic complex by culturing actinomyces strain ATCC 39417
    Patent number: 4572895
    Abstract: A novel antibiotic complex designated BBM-2478 is produced by fermentation of an actinomycete strain J907-21 (ATCC 39417). The complex may be separated chromatographically into two bioactive components designated BBM-2478A and BBM-2478B. The BBM-2478A component displays both antibacterial and antitumor activity while the BBM-2478B component has antibacterial activity.
    Type: Grant
    Filed: February 19, 1985
    Date of Patent: February 25, 1986
    Assignee: Bristol-Myers Company
    Inventors: Masataka Konishi, Koko Sugawara, Takeo Miyaki, Hiroshi Kawaguchi
  • Fermentation process for preparation of antibiotic Bu-2517
    Patent number: 4533631
    Abstract: Disclosed is a process for preparation of the water-soluble peptide antibiotic designated Bu-2517 by fermentation of Empedobacter sp. strain G393-B445 (ATCC 31962).
    Type: Grant
    Filed: March 25, 1983
    Date of Patent: August 6, 1985
    Assignee: Bristol-Myers Company
    Inventors: Hiroshi Kawaguchi, Masataka Konishi, Koko Sugawara, Koji Tomita
  • BBM-2478 Antibiotic complex
    Patent number: 4518589
    Abstract: A novel antibiotic complex designated BBM-2478 is produced by fermentation of an actinomycete strain J907-21 (ATCC 39417). The complex may be separated chromatographically into two bioactive components designated BBM-2478A and BBM-2478B. The BBM-2478A component displays both antibacterial and antitumor activity while the BBM-2478B component has antibacterial activity.
    Type: Grant
    Filed: October 3, 1983
    Date of Patent: May 21, 1985
    Assignee: Bristol-Myers Company
    Inventors: Masataka Konishi, Koko Sugawara, Takeo Miyaki, Hiroshi Kawaguchi
  • Antibiotic compound
    Patent number: 4409210
    Abstract: A novel water-soluble peptide designated herein as Bu-2517 is produced by fermentation of Empedobacter sp. strain G393-B445 (ATCC 31962). The antibiotic exists in a cyclic depsipeptide structure and contains the amino acids D-serine, D-proline, L-proline, D-threo-.beta.-hydroxyaspartic acid, L-threo-.beta.-hydroxyaspartic acid, L-arginine and trans-L-3-hydroxyproline and the residue of the C.sub.14 fatty acid, 3-hydroxytetradecanoic acid. The Bu-2517 antibiotic inhibits the growth of a variety of aerobic and anaerobic gram-positive bacteria.
    Type: Grant
    Filed: January 15, 1982
    Date of Patent: October 11, 1983
    Assignee: Bristol-Myers Company
    Inventors: Hiroshi Kawaguchi, Masataka Konishi, Koko Sugawara, Koji Tomita