Patents by Inventor Kolbot By

Kolbot By has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Solid Forms of 2-[3-[4-Amino-3-(2-Fluoro-4-Phenoxy-Phenyl)Pyrazolo[3,4-d]Pyrimidin-1-YL] Piperidine-1-Carbonyl]-4-Methyl-4-[4-(Oxetan-3-YL)Piperazin-1-YL]Pent-2-Enenitrile
    Publication number: 20230399330
    Abstract: Solid forms of Compound (I): are disclosed. Pharmaceutical compositions comprising the same, methods of treating disorders and conditions mediated by BTK activity using the same, and methods for making Compound (I) and solid forms thereof are also disclosed.
    Type: Application
    Filed: May 16, 2023
    Publication date: December 14, 2023
    Applicant: Principia Biopharma Inc.
    Inventors: Kolbot By, Katherine Chu, Mohammad R. Masjedizadeh, Pasit Phiasivongsa, Jiang Zhu
  • Crystalline forms of 2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)-1H-pyrazolo[3,4-D]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile
    Patent number: 11814390
    Abstract: Crystalline forms of Compound (I): are disclosed. Pharmaceutical compositions comprising the same, methods of treating disorders and conditions mediated by BTK activity using the same, and methods for making Compound (I) and crystalline forms thereof are also disclosed.
    Type: Grant
    Filed: January 21, 2021
    Date of Patent: November 14, 2023
    Assignee: Principia Biopharma Inc.
    Inventors: Pasit Phiasivongsa, Kolbot By, Jean Baum
  • Solid forms of 2-[3-[4-amino-3-(2-fluoro-4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile
    Patent number: 11708370
    Abstract: Solid forms of Compound (I): are disclosed. Pharmaceutical compositions comprising the same, methods of treating disorders and conditions mediated by BTK activity using the same, and methods for making Compound (I) and solid forms thereof are also disclosed.
    Type: Grant
    Filed: December 17, 2020
    Date of Patent: July 25, 2023
    Assignee: Principia Biopharma Inc.
    Inventors: Pasit Phiasivongsa, Katherine Chu, Jiang Zhu, Kolbot By, Mohammad Reza Masjedizadeh
  • Crystalline forms of 2-[3-[4-amino-3-(2-fluoro-4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4,4-dimethylpent-2-enenitrile
    Patent number: 11667641
    Abstract: Crystalline forms of Compound (I): are disclosed. Pharmaceutical compositions comprising the same, methods of inhibiting BTK using the same, and methods for making crystalline forms of Compound (I) are also disclosed.
    Type: Grant
    Filed: January 7, 2021
    Date of Patent: June 6, 2023
    Assignee: Principia Biopharma Inc.
    Inventors: Pasit Phiasivongsa, Jiang Zhu, Kolbot By, Mohammad Reza Masjedizadeh
  • CRYSTALLINE FORMS OF 2-[3-[4-AMINO-3-(2-FLUORO-4-PHENOXY-PHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-1-YL]PIPERIDINE-1-CARBONYL]-4-METHYL-4-[4-(OXETAN-3-YL)PIPERAZIN-1-YL]PENT-2-ENENITRILE
    Publication number: 20210221818
    Abstract: Crystalline forms of Compound (I): are disclosed. Pharmaceutical compositions comprising the same, methods of treating disorders and conditions mediated by BTK activity using the same, and methods for making Compound (I) and crystalline forms thereof are also disclosed.
    Type: Application
    Filed: January 21, 2021
    Publication date: July 22, 2021
    Inventors: Pasit Phiasivongsa, Kolbot By, Jean Baum
  • CRYSTALLINE FORMS OF 2-[3-[4-AMINO-3-(2-FLUORO-4-PHENOXY-PHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-1-YL]PIPERIDINE-1-CARBONYL]-4,4-DIMETHYLPENT-2-ENENITRILE
    Publication number: 20210206772
    Abstract: Crystalline forms of Compound (I): are disclosed. Pharmaceutical compositions comprising the same, methods of inhibiting BTK using the same, and methods for making crystalline forms of Compound (I) are also disclosed.
    Type: Application
    Filed: January 7, 2021
    Publication date: July 8, 2021
    Inventors: Pasit Phiasivongsa, Jiang Zhu, Kolbot By, Mohammad Reza Masjedizadeh
  • SOLID FORMS OF 2-[3-[4-AMINO-3-(2-FLUORO-4-PHENOXY-PHENYL)PYRAZOLO[3,4-D]PYRIMIDIN-1-YL]PIPERIDINE-1-CARBONYL]-4-METHYL-4-[4-(OXETAN-3-YL)PIPERAZIN-1-YL]PENT-2-ENENITRILE
    Publication number: 20210198264
    Abstract: Solid forms of Compound (I): are disclosed. Pharmaceutical compositions comprising the same, methods of treating disorders and conditions mediated by BTK activity using the same, and methods for making Compound (I) and solid forms thereof are also disclosed.
    Type: Application
    Filed: December 17, 2020
    Publication date: July 1, 2021
    Inventors: Pasit Phiasivongsa, Katherine Chu, Jiang Zhu, Kolbot By, Mohammad Reza Masjedizadeh
  • Prodrugs of peptide epoxy ketone protease inhibitors
    Patent number: 10682419
    Abstract: This disclosure features compounds that are useful as pro-drugs of epoxy ketone protease inhibitors.
    Type: Grant
    Filed: January 29, 2018
    Date of Patent: June 16, 2020
    Assignee: ONYX THERAPEUTICS, INC.
    Inventors: Pasit Phiasivongsa, Gary W. Luehr, Ge Peng, Kolbot By, Shabbir T. Anik
  • Processes for making triazolo[4,5D] pyramidine derivatives and intermediates thereof
    Patent number: 10654825
    Abstract: Provided herein are, inter alia, methods for making triazolo[4,5]pyramidine derivatives and intermediates thereof that are useful for treating diseases.
    Type: Grant
    Filed: March 30, 2018
    Date of Patent: May 19, 2020
    Assignee: CORVUS PHARMACEUTICALS, INC.
    Inventors: Kolbot By, William Benton Jones, Bradley Hamilton Wolfe
  • PROCESSES FOR MAKING TRIAZOLO[4,5D] PYRAMIDINE DERIVATIVES AND INTERMEDIATES THEREOF
    Publication number: 20180290999
    Abstract: Provided herein are, inter alia, methods for making triazolo[4,5]pyramidine derivatives and intermediates thereof that are useful for treating diseases.
    Type: Application
    Filed: March 30, 2018
    Publication date: October 11, 2018
    Inventors: Kolbot By, William Benton Jones, Bradley Hamilton Wolfe
  • PRODRUGS OF PEPTIDE EPOXY KETONE PROTEASE INHIBITORS
    Publication number: 20180147291
    Abstract: This disclosure features compounds that are useful as pro-drugs of epoxy ketone protease inhibitors.
    Type: Application
    Filed: January 29, 2018
    Publication date: May 31, 2018
    Inventors: Pasit Phiasivongsa, Gary W. Luehr, Ge Peng, Kolbot By, Shabbir T. Anik
  • Prodrugs of peptide epoxy ketone protease inhibitors
    Patent number: 9878047
    Abstract: This disclosure features compounds that are useful as pro-drugs of epoxy ketone protease inhibitors.
    Type: Grant
    Filed: March 9, 2016
    Date of Patent: January 30, 2018
    Assignee: Onyx Therapeutics, Inc.
    Inventors: Pasit Phiasivongsa, Gary W. Luehr, Ge Peng, Kolbot By, Shabbir T. Anik
  • PRODRUGS OF PEPTIDE EPOXY KETONE PROTEASE INHIBITORS
    Publication number: 20160263234
    Abstract: This disclosure features compounds that are useful as pro-drugs of epoxy ketone protease inhibitors.
    Type: Application
    Filed: March 9, 2016
    Publication date: September 15, 2016
    Inventors: Pasit Phiasivongsa, Gary W. Luehr, Ge Peng, Kolbot By, Shabbir T. Anik
  • Prodrugs of peptide epoxy ketone protease inhibitors
    Patent number: 9315542
    Abstract: This disclosure features compounds that are useful as pro-drugs of epoxy ketone protease inhibitors.
    Type: Grant
    Filed: September 30, 2013
    Date of Patent: April 19, 2016
    Assignee: Onyx Therapeutics, Inc.
    Inventors: Pasit Phiasivongsa, Gary Luehr, Ge Peng, Kolbot By, Shabbir T. Anik
  • Prodrugs of peptide epoxy ketone protease inhibitors
    Patent number: 9309283
    Abstract: Provided herein are compounds of formula (I): which are pro-drugs of epoxy ketone protease inhibitors. The compounds disclosed herein include one or more moieties that (i) confer enhanced solubility, permeability, pharmacokinetics, and/or pharmacodynamics properties to epoxy ketone protease inhibitors, and (ii) can be released in vivo. Also provided herein are pharmaceutical compositions of the compounds of formula (I), and methods of using the compounds of formula (I) to treat diseases and conditions.
    Type: Grant
    Filed: July 9, 2013
    Date of Patent: April 12, 2016
    Assignee: Onyx Therapeutics, Inc.
    Inventors: Pasit Phiasivongsa, Gary W. Luehr, Ge Peng, Kolbot By, Shabbir T. Anik
  • Prodrugs of Peptide Epoxy Ketone Protease Inhibitors
    Publication number: 20140105921
    Abstract: This disclosure features compounds that are useful as pro-drugs of epoxy ketone protease inhibitors.
    Type: Application
    Filed: July 9, 2013
    Publication date: April 17, 2014
    Inventors: Pasit Phiasivongsa, Gary Luehr, Ge Peng, Kolbot By, Shabbir T. Anik
  • Prodrugs of Peptide Epoxy Ketone Protease Inhibitors
    Publication number: 20140100168
    Abstract: This disclosure features compounds that are useful as pro-drugs of epoxy ketone protease inhibitors.
    Type: Application
    Filed: July 9, 2013
    Publication date: April 10, 2014
    Inventors: Pasit Phiasivongsa, Gary Luehr, Ge Peng, Kolbot By, Shabbir T. Anik
  • Prodrugs of Peptide Epoxy Ketone Protease Inhibitors
    Publication number: 20140100154
    Abstract: This disclosure features compounds that are useful as pro-drugs of epoxy ketone protease inhibitors.
    Type: Application
    Filed: September 30, 2013
    Publication date: April 10, 2014
    Applicant: Onyx Therapeutics, Inc.
    Inventors: Pasit Phiasivongsa, Gary Luehr, Ge Peng, Kolbot By, Shabbir T. Anik
  • Synthetic methods and intermediates for steroisomeric compounds useful for the treatment of gastrointestinal and central nervous system disorders
    Patent number: 7629466
    Abstract: The subject invention provides methods and/or processes for making stereoisomeric compounds of formula (X): wherein the variables are as defined herein, and compositions for the safe and effective treatment of various gastrointestinal disorders including, but not limited to, gastroparesis, gastroesophageal reflux and related conditions. The compounds of the subject invention are also useful in treating a variety of conditions involving the central nervous system.
    Type: Grant
    Filed: April 25, 2008
    Date of Patent: December 8, 2009
    Assignee: ARYx Therapeutics, Inc.
    Inventors: Kolbot By, Jinun-Ban Yeh, Ponny Pang
  • Synthetic Methods and Intermediates for Stereoisomeric Compounds Useful for the Treatment of Gastrointestinal and Central Nervous System Disorders
    Publication number: 20090137810
    Abstract: The subject invention provides methods and/or processes for making stereoisomeric compounds of formula (X): wherein the variables are as defined herein, and compositions for the safe and effective treatment of various gastrointestinal disorders including, but not limited to, gastroparesis, gastroesophageal reflux and related conditions. The compounds of the subject invention are also useful in treating a variety of conditions involving the central nervous system.
    Type: Application
    Filed: April 25, 2008
    Publication date: May 28, 2009
    Applicant: ARYx Therapeutics, Inc.
    Inventors: Kolbot By, J. B. Yeh, Ponny Pang