Patents by Inventor Kondamraj Birudaraj

Kondamraj Birudaraj has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pharmaceutical composition and process
    Patent number: 7893037
    Abstract: The present invention relates to a method of forming granules of (2R,3S,4R,5R)-5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-2-azido-3,4-bis-iso-butyryloxy-tetrahydro-furan-2-ylmethyl isobutyrate; hydrochloride salt (I), comprising mixing I, with a granulating amount of a granulating liquid, and a polyethylene glycol (PEG)/polypropylene glycol (PPG) block copolymer as a binder and solubility enhancer to form wet granules which are then dried to remove the granulating liquid.
    Type: Grant
    Filed: March 28, 2008
    Date of Patent: February 22, 2011
    Assignee: Roche Palo Alto LLC
    Inventors: Kondamraj Birudaraj, Michael Thomas Brandl, Shridhar Hegde, Felix Sana, Dimitrios Stefanidis
  • Pharmaceutical composition and process
    Patent number: 7795237
    Abstract: The present invention relates to a pharmaceutical composition comprising a solid suspension prepared by hot melt extrusion of isobutyric acid (2R,3S,4R,5R)-5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-2-azido-3,4-bis-iso-butyryloxy-tetrahydro-furan-2-ylmethyl ester; hydrochloride salt (I) and a polyethylene glycol (PEG)/polypropylene glycol (PPG) block copolymer.
    Type: Grant
    Filed: December 13, 2006
    Date of Patent: September 14, 2010
    Inventors: Hashim A. Ahmed, Thomas Vernon Alfredson, Kondamraj Birudaraj, Michael Thomas Brandl, Wantanee Phuapradit, Navnit Hargovindas Shah, Dimitrios Stefanidis
  • Pharmaceutical composition and process
    Publication number: 20080260826
    Abstract: The present invention relates to a method of forming granules of (2R,3S,4R,5R)-5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-2-azido-3,4-bis-iso-butyryloxy-tetrahydro-furan-2-ylmethyl isobutyrate; hydrochloride salt (I), comprising mixing I, with a granulating amount of a granulating liquid, and a polyethylene glycol (PEG)/polypropylene glycol (PPG) block copolymer as a binder and solubility enhancer to form wet granules which are then dried to remove the granulating liquid.
    Type: Application
    Filed: March 28, 2008
    Publication date: October 23, 2008
    Inventors: Kondamraj Birudaraj, Michael Thomas Brandl, Shridhar Hegde, Felix Sana, Dimitrios Stefanidis
  • Polymorphic antiviral nucleoside compounds
    Patent number: 7393839
    Abstract: The present invention relates to the polymorphic crystalline hydrochloride salts of a nucleoside valinate ester according to formula Ib, methods of treating diseases mediated by Hepatitis C Virus and pharmaceutical composition containing Ib
    Type: Grant
    Filed: September 13, 2004
    Date of Patent: July 1, 2008
    Assignee: Roche Palo Alto LLC
    Inventors: Kondamraj Birudaraj, Keith McCarthy, legal representative, Anthony Prince
  • Pharmaceutical composition and process
    Publication number: 20070202175
    Abstract: The present invention relates to a pharmaceutical composition comprising a solid suspension prepared by hot melt extrusion of isobutyric acid (2R,3S,4R,5R)-5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-2-azido-3,4-bis-iso-butyryloxy-tetrahydro-furan-2-ylmethyl ester; hydrochloride salt (I) and a polyethylene glycol (PEG)/polypropylene glycol (PPG) block copolymer.
    Type: Application
    Filed: December 13, 2006
    Publication date: August 30, 2007
    Inventors: Hashim Ahmed, Thomas Alfredson, Kondamraj Birudaraj, Michael Brandl, Wantanee Phuapradit, Navnit Shah, Dimitrios Stefanidis
  • Polymorphic antiviral nucleoside compounds
    Publication number: 20050130915
    Abstract: The present invention relates to the polymorphic crystalline hydrochloride salts of a nucleoside valinate ester according to formula Ib, methods of treating diseases mediated by Hepatitis C Virus and pharmaceutical composition containing Ib.
    Type: Application
    Filed: September 13, 2004
    Publication date: June 16, 2005
    Inventors: Kondamraj Birudaraj, Anthony Prince, Keith McCarthy