Abstract: The present invention provides piperidin-4-y1 azetidine derivatives, as well as their compositions and methods of use, that modulate the activity of Janus kinase 1 (JAK1) and are useful in the treatment of diseases related to the activity of JAK1 including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.

Abstract: The present invention provides benzamide compounds, compositions containing the benzamides, and use of the benzamides for inhibiting androgen receptor (AR) and/or aldo-keto reductase family 1 member C3 (AKR1C3). Also described herein methods for the treatment of hormone-mediated diseases and conditions, including hormone-related cancers such as castration resistant prostate cancer.

Abstract: A data backup method includes querying a first block of a first blockchain for unused transaction output information based on a first condition being met, the first block including each block of all blocks included in the first blockchain; generating transaction information according to the unused transaction output information obtained based on the querying, the transaction information indicating a transaction operation based on an account address to which the unused transaction output information belongs; recording the transaction information in a second block and releasing the second block, and recording the second block on which a consensus is reached on a second blockchain; and backing up the first blockchain into a storage system, and deleting the first blockchain. Counterpart apparatus, terminal, server, and/or non-transitory computer-readable medium are also contemplated.

Abstract: Methods and compositions are provided for the treatment of Parkinson's Disease. Aspects of the methods include administering Miro1 reducer. Also provided are reagents and kits for practicing the subject methods. In some embodiments, a method is provided for reducing undesirable levels of Miro1 in a cell having depolarized or otherwise damaged mitochondria. In some embodiments the cell is in vivo, e.g. in an animal model for PD, in an individual diagnosed with PD, in a clinical trial for treatment of PD, and the like.

Abstract: A hygiene monitoring and management system including a monitoring module and a display. The management module with an input and that receives data via the input. The received data includes one or more locations of a device in a facility, and the management module further includes one or both of software and hardware configured to generate data representative of cleaning behavior associated with the device based on the received data. The cleaning behavior includes timing and movement of the device in the facility, and a cleanliness level of at least one area in the facility.

Abstract: A hygiene monitoring and management system including a monitoring module and a display. The management module with an input and that receives data via the input. The received data includes one or more locations of a device in a facility, and the management module further includes one or both of software and hardware configured to generate data representative of cleaning behavior associated with the device based on the received data. The cleaning behavior includes timing and movement of the device in the facility, and a cleanliness level of at least one area in the facility.

Abstract: Systems, methods, and media for efficient file replication are provided herein. According to some embodiments, exemplary methods may include detecting a write operation occurring within an operating system of the computing system, identifying block parameters for the write operation, as well as one or more of buffering and batching the write operation, and transmitting the write operation to a replication receiver system.

Abstract: A hygiene monitoring and management system including a monitoring module and a display. The management module with an input and that receives data via the input. The received data includes one or more locations of a device in a facility, and the management module further includes one or both of software and hardware configured to generate data representative of cleaning behavior associated with the device based on the received data. The cleaning behavior includes timing and movement of the device in the facility, and a cleanliness level of at least one area in the facility.

Abstract: A Real Time Locating System (RTLS) hygiene management and monitoring system for individuals and companies to manage and monitor the hygiene of their surroundings. In some embodiments of the invention, RTLS is used to monitor and manage cleanliness of rooms and surfaces and the location of cleaning supplies and cleaning personnel. The invention provides improved efficiency and quality of hygiene services. For instance, the invention can enable prioritization of cleaning, improve efficient use of cleaning supplies and cleaning personnel, track short and long term cleaning operations, and provide insight into ineffective cleaning.

Abstract: A system of determining container load units from dispatch load units which allows for packing a container load unit by a homogeneous (identical) type of dispatch load unit and/or by heterogeneous (different types) of dispatch load units. The system allows for the incorporation of practical operational factors, packing preferences and also allows for various empirical overrides. The quantity of container load units and the packing arrangements for each container load unit are generated for various lots of items.

Abstract: A Real Time Locating System (RTLS) hygiene management and monitoring system for individuals and companies to manage and monitor the hygiene of their surroundings. In some embodiments of the invention, RTLS is used to monitor and manage cleanliness of rooms and surfaces and the location of cleaning supplies and cleaning personnel. The invention provides improved efficiency and quality of hygiene services. For instance, the invention can enable prioritization of cleaning, improve efficient use of cleaning supplies and cleaning personnel, track short and long term cleaning operations, and provide insight into ineffective cleaning.

Abstract: The present invention provides a method for detecting and treating hematologic malignancies including leukemia such as acute lymphoblastic leukemia (ALL) in a subject and a method for determining disease prognosis among leukemia patients by detecting CD9 expression. A kit and device useful for such methods are also provided. In addition, the present invention provides a composition for treating hematologic malignancies such as leukemia by suppressing CD9 expression or activity.

Abstract: Systems, methods, and media for efficient file replication are provided herein. According to some embodiments, exemplary methods may include detecting a write operation occurring within an operating system of the computing system, identifying block parameters for the write operation, as well as one or more of buffering and batching the write operation, and transmitting the write operation to a replication receiver system.

Abstract: A Real Time Locating System (RTLS) hygiene management and monitoring system for individuals and companies to manage and monitor the hygiene of their surroundings. For example, the system can be used in conjunction with a cleaning device and can include a locating module, a display module, and a cleanliness monitoring system. The locating module determines a location of the cleaning device in an area and to track movement of the cleaning device within the area. The display module includes a graphical layout of the area. The cleanliness monitoring system generates data representative of a path that the cleaning device has traversed in the area and at least one aspect of cleaning behavior of the device in the area. The display module displays the data representative of the path and the data representative of the at least one aspect of cleaning behavior, and one or both of the path and the at least one aspect of cleaning behavior is color-coded on the display module.

Abstract: A Real Time Locating System (RTLS) hygiene management and monitoring system for individuals and companies to manage and monitor the hygiene of their surroundings. For example, the system can be used in conjunction with a cleaning device and can include a locating module, a display module, and a cleanliness monitoring system. The locating module determines a location of the cleaning device in an area and to track movement of the cleaning device within the area. The display module includes a graphical layout of the area. The cleanliness monitoring system generates data representative of a path that the cleaning device has traversed in the area and at least one aspect of cleaning behavior of the device in the area. The display module displays the data representative of the path and the data representative of the at least one aspect of cleaning behavior, and one or both of the path and the at least one aspect of cleaning behavior is color-coded on the display module.

Abstract: A Real Time Locating System (RTLS) hygiene management and monitoring system for individuals and companies to manage and monitor the hygiene of their surroundings. In some embodiments of the invention, RTLS is used to monitor and manage cleanliness of rooms and surfaces and the location of cleaning supplies and cleaning personnel. The invention provides improved efficiency and quality of hygiene services. For instance, the invention can enable prioritization of cleaning, improve efficient use of cleaning supplies and cleaning personnel, track short and long term cleaning operations, and provide insight into ineffective cleaning.

Abstract: A Real Time Locating System (RTLS) hygiene management and monitoring system for individuals and companies to manage and monitor the hygiene of their surroundings. In some embodiments of the invention, RTLS is used to monitor and manage cleanliness of rooms and surfaces and the location of cleaning supplies and cleaning personnel. The invention provides improved efficiency and quality of hygiene services. For instance, the invention can enable prioritization of cleaning, improve efficient use of cleaning supplies and cleaning personnel, track short and long term cleaning operations, and provide insight into ineffective cleaning.

Abstract: A Real Time Locating System (RTLS) hygiene management and monitoring system for individuals and companies to manage and monitor the hygiene of their surroundings. In some embodiments of the invention, RTLS is used to monitor and manage cleanliness of rooms and surfaces and the location of cleaning supplies and cleaning personnel. The invention provides improved efficiency and quality of hygiene services. For instance, the invention can enable prioritization of cleaning, improve efficient use of cleaning supplies and cleaning personnel, track short and long term cleaning operations, and provide insight into ineffective cleaning.

Abstract: A Real Time Locating System (RTLS) hygiene management and monitoring system for individuals and companies to manage and monitor the hygiene of their surroundings. In some embodiments of the invention, RTLS is used to monitor and manage cleanliness of rooms and surfaces and the location of cleaning supplies and cleaning personnel. The invention provides improved efficiency and quality of hygiene services. For instance, the invention can enable prioritization of cleaning, improve efficient use of cleaning supplies and cleaning personnel, track short and long term cleaning operations, and provide insight into ineffective cleaning.