Patents by Inventor Kongnara Papangkorn
Kongnara Papangkorn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11969434Abstract: Disclosed is a method and an oral composition for treating CNS disorders. An embodiment of the invention comprises orally administering an allopregnanolone containing composition to a subject having a CNS disorder. Exemplary CNS disorders include sleep disorders, mood disorders, dysthymic disorders, bipolar disorders, anxiety disorders, stress disorders, compulsive disorders, schizophrenia spectrum disorders, convulsive disorders, memory disorders, cognition disorders, movement disorders, personality disorders, autism spectrum disorders, substance abuse disorders, dementia, pain, traumatic brain injury (TBI), vascular disease, withdrawal syndrome, and tinnitus. The composition and methods disclosed herein exhibit effective oral absorption/bioavailability.Type: GrantFiled: August 29, 2022Date of Patent: April 30, 2024Inventors: Jonathan Ogle, Benjamin J. Bruno, Kongnara Papangkorn, Samuel Akapo, Joel Frank, Nachiappan Chidambaram, Mahesh V. Patel
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Publication number: 20230390304Abstract: Disclosed is a method and composition for treating CNS disorders in a subject. In an embodiment, the method preferably comprises the ordered steps of identifying a subject having or being predisposed to epilepsy, and orally administering to the subject an AED. The administration preferably comprises an administration regimen of a predetermined quantity of the AED, at a predetermined frequency, and for a predetermined duration. The subject preferably comprises a subject experiencing seizure clusters, WWE, and more especially a WWE of childbearing age. The composition preferably comprises a NAS, and more especially an ENAS. The method preferably results in the prevention, or reduced frequency or magnitude of epileptic seizures.Type: ApplicationFiled: June 2, 2023Publication date: December 7, 2023Applicant: Lipocine Inc.Inventors: Benjamin J. Bruno, Nachiappan Chidambaram, Jonathan Ogle, Kongnara Papangkorn, Mahesh V. Patel
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Publication number: 20230321116Abstract: Disclosed are methods and oral compositions for treating CNS disorders. An embodiment of the invention comprises orally administering a 3?-OH-5?-pregnan-20-one containing composition to a subject having a CNS disorder. The composition preferably exhibits a fast release rate of the 3?-OH-5?-pregnan-20-one. The current compositions may provide desired serum levels of 3?-OH-5?-pregnan-20-one to effectively treat CNS disorders. The oral compositions and methods disclosed herein may be administered to a subject in need of CNS disorder therapy, to deliver therapeutically effective amounts of 3?-OH-5?-pregnan-20-one for treating CNS disorders.Type: ApplicationFiled: March 28, 2022Publication date: October 12, 2023Applicant: Lipocine Inc.Inventors: Kilyoung Kim, Kongnara Papangkorn, Kiran Kumar Vangara, Nachiappan Chidambaram, Mahesh V. Patel
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Publication number: 20220354867Abstract: The present disclosure is drawn to compositions and methods for treating CNS disorders. In one embodiment, an oral pharmaceutical composition can comprise a therapeutically effective amount of pregn-4-ene-3,20-dione; and a pharmaceutically acceptable carrier that provides formation of either 3?-OH-5?-pregnan-20-one, or 3?-OH-5?-pregnan-20-one, or both in an amount sufficient to treat a CNS disorder when orally administered to a subject. In another embodiment, a method of treating a CNS disorder can comprise orally administering to a subject, a therapeutically effective amount of pregn-4-ene-3,20-dione that provides an amount of GABA receptor binding pregn-4-ene-3,20-dione metabolites that is sufficient to treat the CNS disorder.Type: ApplicationFiled: May 10, 2022Publication date: November 10, 2022Applicant: Lipocine Inc.Inventors: Mahesh V. Patel, Nachiappan Chidambaram, Kilyoung Kim, Kongnara Papangkorn, Benjamin J. Bruno, Kiran Kumar Vangara
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Patent number: 11478485Abstract: The present disclosure is drawn to compositions and methods for treating CNS disorders. In one embodiment, an oral pharmaceutical composition can comprise a therapeutically effective amount of pregn-4-ene-3,20-dione; and a pharmaceutically acceptable carrier that provides formation of either 3?-OH-5?-pregnan-20-one, or 3?-OH-5?-pregnan-20-one, or both in an amount sufficient to treat a CNS disorder when orally administered to a subject. In another embodiment, a method of treating a CNS disorder can comprise orally administering to a subject, a therapeutically effective amount of pregn-4-ene-3,20-dione that provides an amount of GABA receptor binding pregn-4-ene-3,20-dione metabolites that is sufficient to treat the CNS disorder.Type: GrantFiled: May 10, 2022Date of Patent: October 25, 2022Inventors: Mahesh V. Patel, Nachiappan Chidambaram, Kilyoung Kim, Kongnara Papangkorn, Benjamin J. Bruno, Kiran Kumar Vangara
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Patent number: 11337987Abstract: The present disclosure is drawn to compositions and methods for treating CNS disorders. In one embodiment, an oral pharmaceutical composition can comprise a therapeutically effective amount of pregn-4-ene-3,20-dione; and a pharmaceutically acceptable carrier that provides formation of either 3?-OH-5?-pregnan-20-one, or 3?-OH-5?-pregnan-20-one, or both in an amount sufficient to treat a CNS disorder when orally administered to a subject. In another embodiment, a method of treating a CNS disorder can comprise orally administering to a subject, a therapeutically effective amount of pregn-4-ene-3,20-dione that provides an amount of GABA receptor binding pregn-4-ene-3,20-dione metabolites that is sufficient to treat the CNS disorder.Type: GrantFiled: May 7, 2021Date of Patent: May 24, 2022Inventors: Mahesh V. Patel, Nachiappan Chidambaram, Kilyoung Kim, Kongnara Papangkorn, Benjamin J. Bruno, Kiran Kumar Vangara
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Publication number: 20220105241Abstract: Embodiments disclosed herein relates articles at least partially coated with fluorapatites to reduce downgrowth as well as methods of making and using the same.Type: ApplicationFiled: January 9, 2020Publication date: April 7, 2022Inventors: Sujeevini Jeyapalina, James Beck, Kent Bachus, John Colombo, Brian Bennett, Kongnara Papangkorn
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Publication number: 20220000888Abstract: An ophthalmic composition can include dexamethasone phosphate, or a salt thereof, dexamethasone, but in an amount not greater than 1.0 wt % relative to the amount of dexamethasone phosphate, or a salt thereof, and water. The ophthalmic composition can have a pH of about 5 to about 8 and a tonicity of from about 100 mOsm/kg to about 760 mOsm/kg.Type: ApplicationFiled: June 25, 2021Publication date: January 6, 2022Applicant: Aciont Inc.Inventors: John W. Higuchi, Kongnara Papangkorn
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Publication number: 20210361673Abstract: The present disclosure is drawn to a methods of treating viral infections using androgen receptor agonists and compositions and dosages suitable therefor.Type: ApplicationFiled: May 15, 2020Publication date: November 25, 2021Applicant: Lipocine Inc.Inventors: Kongnara Papangkorn, Mahesh V. Patel, Nachiappan Chidambaram, Kilyoung Kim, Ben Bruno
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Publication number: 20200383946Abstract: A lipoic acid formulation can include water and an amount of a lipoic acid agent dissolved in the water. In some examples, a buffering agent can also be included in the formulation in an amount sufficient to dissolve the lipoic acid agent in the water. The lipoic acid formulation can generally have a pH of from about 6 to about 8.Type: ApplicationFiled: May 7, 2020Publication date: December 10, 2020Applicant: Aciont Inc.Inventors: John W. Higuchi, Kongnara Papangkorn
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Publication number: 20200030230Abstract: A non-invasive ocular drug delivery device can include a housing adapted to couple to an eye of a subject. An active agent matrix can be coupled to the housing. The active agent matrix can include an electrospun material having a combination of a density, a thickness, and an ocular surface area configured to hold and retain an active agent prior to application of the device to the eye, and deliver an effective dose of an active agent within 30 minutes of application of the device to the eye.Type: ApplicationFiled: July 15, 2019Publication date: January 30, 2020Applicant: Aciont Inc.Inventors: John W. Higuchi, Kongnara Papangkorn
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Publication number: 20190216830Abstract: An ophthalmic composition can include dexamethasone phosphate, or a salt thereof, dexamethasone, but in an amount not greater than 1.0 wt % relative to the amount of dexamethasone phosphate, or a salt thereof, and water. The ophthalmic composition can have a pH of about 5 to about 8 and a tonicity of from about 100 mOsm/kg to about 760 mOsm/kg.Type: ApplicationFiled: October 9, 2018Publication date: July 18, 2019Applicant: Aciont Inc.Inventors: John W. Higuchi, Kongnara Papangkorn
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Publication number: 20190105194Abstract: A method of treating a subject with an ocular condition responsive to steroid therapy can include administering a threshold dose of a steroid to an eye of the subject in a therapeutically effective regimen that minimizes an intraocular pressure (IOP) increase above a baseline level.Type: ApplicationFiled: October 6, 2017Publication date: April 11, 2019Applicant: Aciont Inc.Inventors: John W. Higuchi, Kongnara Papangkorn
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Publication number: 20190105264Abstract: A non-invasive ocular drug delivery device can include a housing adapted to couple to an eye of a subject. An active agent matrix can be coupled to the housing. The active agent matrix can include an electro spun material having a combination of a density, a thickness, and an ocular surface area configured to hold and retain an active agent prior to application of the device to the eye, and deliver an effective dose of an active agent within 30 minutes of application of the device to the eye.Type: ApplicationFiled: October 6, 2017Publication date: April 11, 2019Applicant: Aciont Inc.Inventors: John W. Higuchi, Kongnara Papangkorn