Patents by Inventor Konobu KIMURA

Konobu KIMURA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10895522
    Abstract: Disclosed is a particle analysis method for identifying infections, comprising: step A of irradiating light on a measurement sample prepared by mixing a test blood specimen containing particles, collected from a subject, a fluorescent dye that stains a nucleic acid, and a hemolytic agent, thereby acquiring scattered light and fluorescence from each particle contained in the measurement sample, step B of specifying particles that are substantially not contained in blood of control subjects not suffering from infection and are determined to be neutrophils contained in blood of patients with infection, based on the scattered light and the fluorescence, and acquiring particle number information on the specified particles, and step C of determining whether the test blood specimen is a specimen collected from patients with bacterial infection or a specimen collected from patients with viral infection, based on the particle number information.
    Type: Grant
    Filed: June 8, 2018
    Date of Patent: January 19, 2021
    Assignee: SYSMEX CORPORATION
    Inventor: Konobu Kimura
  • Publication number: 20200340909
    Abstract: Disclosed is a method for supporting disease analysis, the method including classifying, on the basis of images obtained from a plurality of analysis target cells contained in a specimen collected from a subject, a morphology of each analysis target cell, and obtaining cell morphology classification information corresponding to the specimen, on the basis of a result of the classification; and analyzing a disease of the subject by means of a computer algorithm, on the basis of the cell morphology classification information.
    Type: Application
    Filed: April 24, 2020
    Publication date: October 29, 2020
    Inventors: Akimichi OHSAKA, Yoko TABE, Konobu KIMURA
  • Publication number: 20200150021
    Abstract: Disclosed is a computer-implemented method of analyzing bone marrow fluid, including counting the number of nucleated cells and the number of lipid particles in a bone marrow fluid; and obtaining an index related to bone marrow nucleated cell density, on the basis of the number of nucleated cells and the number of lipid particles.
    Type: Application
    Filed: November 13, 2019
    Publication date: May 14, 2020
    Inventors: Akimichi OHSAKA, Yoko TABE, Koji TSUCHIYA, Konobu KIMURA
  • Patent number: 10578603
    Abstract: A blood analyzer comprises a sample preparing part, a light source, a light receiving part, and a processing part configured to discriminate and count reactive B lymphocytes based on at least one of fluorescent light signals and forward scattered light signals.
    Type: Grant
    Filed: June 16, 2015
    Date of Patent: March 3, 2020
    Assignee: Sysmex Corporation
    Inventors: Konobu Kimura, Kinya Uchihashi, Jo Linssen, Jarob Saker
  • Publication number: 20190347467
    Abstract: Disclosed is an image analysis method including inputting analysis data, including information regarding an analysis target cell to a deep learning algorithm having a neural network structure, and analyzing an image by calculating, by use of the deep learning algorithm, a probability that the analysis target cell belongs to each of morphology classifications of a plurality of cells belonging to a predetermined cell group.
    Type: Application
    Filed: May 8, 2019
    Publication date: November 14, 2019
    Inventors: Akimichi OHSAKA, Yoko TABE, Konobu KIMURA
  • Patent number: 10281458
    Abstract: Disclosed is a blood analyzer including a specimen preparation unit that prepares a measurement specimen by mixing a hemolytic agent that hemolyzes red blood cells, a staining dye that dyes nucleic acids, and a blood specimen; a detector that detects intensity of side scattered light and intensity of fluorescence generated with application of light from the measurement specimen prepared by the specimen preparation unit; and an analysis unit that discriminates white blood cells from giant platelets based on the intensity of side scattered light and the intensity of fluorescence detected by the detector, and counts the white blood cells.
    Type: Grant
    Filed: September 12, 2016
    Date of Patent: May 7, 2019
    Assignee: SYSMEX CORPORATION
    Inventors: Yuji Masuda, Konobu Kimura
  • Patent number: 10161849
    Abstract: Disclosed is a cell analyzer that includes a flow cell through which a measurement specimen containing a body fluid flows, a light emission unit that applies light onto the measurement specimen flowing through the flow cell, a light detection unit that detects forward scattered light generated from cells in the measurement specimen to which the light is applied, an analysis unit that is programmed to analyze the cells in the body fluid based on a forward scattered light signal detected by the light detection unit, and an output unit. The analysis unit is programmed to control the output unit to output information about tumor cells in the body fluid, based on forward scattered light signal intensity and forward scattered light signal width.
    Type: Grant
    Filed: September 9, 2016
    Date of Patent: December 25, 2018
    Assignee: SYSMEX CORPORATION
    Inventor: Konobu Kimura
  • Publication number: 20180356328
    Abstract: Disclosed is a particle analysis method for identifying infections, comprising: step A of irradiating light on a measurement sample prepared by mixing a test blood specimen containing particles, collected from a subject, a fluorescent dye that stains a nucleic acid, and a hemolytic agent, thereby acquiring scattered light and fluorescence from each particle contained in the measurement sample, step B of specifying particles that are substantially not contained in blood of control subjects not suffering from infection and are determined to be neutrophils contained in blood of patients with infection, based on the scattered light and the fluorescence, and acquiring particle number information on the specified particles, and step C of determining whether the test blood specimen is a specimen collected from patients with bacterial infection or a specimen collected from patients with viral infection, based on the particle number information.
    Type: Application
    Filed: June 8, 2018
    Publication date: December 13, 2018
    Applicant: SYSMEX CORPORATION
    Inventor: Konobu KIMURA
  • Patent number: 10107754
    Abstract: A blood analyzer comprises a sample preparing part configured to prepare a measurement sample from a blood sample, an staining dye and diluent, a detecting part configured to detect the fluorescent light intensity and the scattered light intensity, an output part, and an analyzing part configured to identify the population including red blood cells infected by ring-form malaria parasite based on the fluorescent light intensity and the scattered light intensity, and output to the output part the information relating to infection of Plasmodium falciparum based on the scattered light distribution of particles associated with the identified population that includes red blood cells infected by the ring-form malaria parasite.
    Type: Grant
    Filed: August 29, 2016
    Date of Patent: October 23, 2018
    Assignee: SYSMEX CORPORATION
    Inventors: Yuhgi Suzuki, Munehisa Izuka, Konobu Kimura
  • Publication number: 20170074777
    Abstract: Disclosed is a cell analyzer that includes a flow cell through which a measurement specimen containing a body fluid flows, a light emission unit that applies light onto the measurement specimen flowing through the flow cell, a light detection unit that detects forward scattered light generated from cells in the measurement specimen to which the light is applied, an analysis unit that is programmed to analyze the cells in the body fluid based on a forward scattered light signal detected by the light detection unit, and an output unit. The analysis unit is programmed to control the output unit to output information about tumor cells in the body fluid, based on forward scattered light signal intensity and forward scattered light signal width.
    Type: Application
    Filed: September 9, 2016
    Publication date: March 16, 2017
    Applicant: SYSMEX CORPORATION
    Inventor: Konobu KIMURA
  • Publication number: 20170074863
    Abstract: Disclosed is a blood analyzer including a specimen preparation unit that prepares a measurement specimen by mixing a hemolytic agent that hemolyzes red blood cells, a staining dye that dyes nucleic acids, and a blood specimen; a detector that detects intensity of side scattered light and intensity of fluorescence generated with application of light from the measurement specimen prepared by the specimen preparation unit; and an analysis unit that discriminates white blood cells from giant platelets based on the intensity of side scattered light and the intensity of fluorescence detected by the detector, and counts the white blood cells.
    Type: Application
    Filed: September 12, 2016
    Publication date: March 16, 2017
    Applicant: SYSMEX CORPORATION
    Inventors: Yuji MASUDA, Konobu KIMURA
  • Publication number: 20170059486
    Abstract: A blood analyzer comprises a sample preparing part configured to prepare a measurement sample from a blood sample, an staining dye and diluent, a detecting part configured to detect the fluorescent light intensity and the scattered light intensity, an output part, and an analyzing part configured to identify the population including red blood cells infected by ring-form malaria parasite based on the fluorescent light intensity and the scattered light intensity, and output to the output part the information relating to infection of Plasmodium falciparum based on the scattered light distribution of particles associated with the identified population that includes red blood cells infected by the ring-form malaria parasite.
    Type: Application
    Filed: August 29, 2016
    Publication date: March 2, 2017
    Inventors: Yuhgi SUZUKI, Munehisa IZUKA, Konobu KIMURA
  • Patent number: 9329172
    Abstract: A method for analyzing blood cells includes: preparing a measurement specimen for classifying white blood cells, by mixing a sample with a reagent in order to hemolyze red blood cells contained in the sample and to fluorescently stain nucleic acid in white blood cells contained in the sample; detecting, by flowing the prepared measurement specimen in a flow cell, fluorescence emitted from each blood cell in the measurement specimen and two types of scattered light at respective different angles, and obtaining a fluorescence signal and two types of scattered light signals; and classifying the white blood cells into at least four groups and detecting neoplastic lymphocytes, by performing analysis using at least three types of parameters based on the obtained fluorescence signal and two types of scattered light signals.
    Type: Grant
    Filed: November 19, 2013
    Date of Patent: May 3, 2016
    Assignee: SYSMEX CORPORATION
    Inventors: Konobu Kimura, Kinya Uchihashi
  • Publication number: 20150369793
    Abstract: A blood analyzer comprises a sample preparing part, a light source, a light receiving part, and a processing part configured to discriminate and count reactive B lymphocytes based on at least one of fluorescent light signals and forward scattered light signals.
    Type: Application
    Filed: June 16, 2015
    Publication date: December 24, 2015
    Inventors: Konobu KIMURA, Kinya UCHIHASHI, Jo LINSSEN, Jarob SAKER
  • Publication number: 20140147837
    Abstract: A method for analyzing blood cells includes: preparing a measurement specimen for classifying white blood cells, by mixing a sample with a reagent in order to hemolyze red blood cells contained in the sample and to fluorescently stain nucleic acid in white blood cells contained in the sample; detecting, by flowing the prepared measurement specimen in a flow cell, fluorescence emitted from each blood cell in the measurement specimen and two types of scattered light at respective different angles, and obtaining a fluorescence signal and two types of scattered light signals; and classifying the white blood cells into at least four groups and detecting neoplastic lymphocytes, by performing analysis using at least three types of parameters based on the obtained fluorescence signal and two types of scattered light signals.
    Type: Application
    Filed: November 19, 2013
    Publication date: May 29, 2014
    Applicant: Sysmex Corporation
    Inventors: Konobu KIMURA, Kinya UCHIHASHI