Patents by Inventor Konrad Honold

Konrad Honold has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MARKERS FOR THE RESPONSIVENESS TO ANTI-CD44 ANTIBODIES
    Publication number: 20150044232
    Abstract: The present invention relates to means and methods of determining whether a tumor cell or a cancer cell is responsive to an anti-CD44 antibody or to an antigen binding fragment thereof. The method comprises the determination of the major CD44 isoform in a sample, wherein if the major CD44 isoform is CD44s, the tumor cell or cancer cell is responsive to said anti-CD44 antibody. Also means and methods of treating a cancer patient that has been determined to respond to an anti-CD44 antibody are subject of the present invention.
    Type: Application
    Filed: June 12, 2014
    Publication date: February 12, 2015
    Applicant: HOFFMANN-LA ROCHE INC.
    Inventors: Fabian Birzele, Michael Cannarile, Friedrich Feuerhake, Thomas Fischer, Florian Heil, Konrad Honold, Adam Nopora, Annette Schmitt-Graeff, Edgar Voss, Stefan Weigand
  • Imidazo [4,5-B] pyridine and pyrrolo [2,3-B] pyridine protein kinase inhibitors
    Patent number: 8067599
    Abstract: Objects of the present invention are the compounds of formula I their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
    Type: Grant
    Filed: September 4, 2007
    Date of Patent: November 29, 2011
    Assignee: Hoffman-La Roche Inc.
    Inventors: Konrad Honold, Wolfgang Schaefer, Stefan Scheiblich
  • 7H-pyrido[3,4-D]pyrimidin-8-ones, their manufacture and use as protein kinase inhibitors
    Patent number: 8058283
    Abstract: Objects of the present invention are the compounds of formula I their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, medicaments containing them and their manufacture, as well as the use of the above compounds in the control or prevention of illnesses such as cancer.
    Type: Grant
    Filed: January 29, 2007
    Date of Patent: November 15, 2011
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Konrad Honold, Jane Paul, Carl Roeschlaub, Wolfgang Schaefer, Stefan Scheiblich, Thomas Von Hirschheydt, Alan Whittle
  • Heterocyclic carbamate derivatives, their manufacture and use as pharmaceutical agents
    Patent number: 7786113
    Abstract: Objects of the present invention are the compounds of formula I their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
    Type: Grant
    Filed: December 22, 2005
    Date of Patent: August 31, 2010
    Assignee: Hoffman-La Roche Inc.
    Inventors: Konrad Honold, Klaus Kaluza, Birgit Masjost, Wolfgang Schaefer, Stefan Scheiblich
  • Heterocyclic benzylamino derivatives, their manufacture and use as pharmaceutical agents
    Patent number: 7776878
    Abstract: Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
    Type: Grant
    Filed: July 28, 2006
    Date of Patent: August 17, 2010
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Edward Boyd, Frederick Brookfield, Jonathan Gridley, Konrad Honold, Raymond Lau, Stefan Scheiblich
  • Heterocyclic benzylamino derivatives, their manufacture and use as pharmaceutical agents
    Publication number: 20100120840
    Abstract: Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
    Type: Application
    Filed: July 28, 2006
    Publication date: May 13, 2010
    Inventors: Edward Boyd, Frederick Brookfield, Jonathan Gridley, Konrad Honold, Raymond Lau, Stefan Scheiblich
  • Amide derivatives of 3-phenyl-dihydropyrimido[4,5-d]pyrimidinones, their manufacture and use as pharmaceutical agents
    Patent number: 7655651
    Abstract: The present invention relates to novel amide derivatives of 3-phenyl dihydropyrimido[4,5-d]pyrimidinones, to a process for their manufacture, medicaments containing them and their manufacture as well as the use of these compounds as pharmaceutically active agents. The present derivatives are new compounds of the general formula (I).
    Type: Grant
    Filed: August 30, 2005
    Date of Patent: February 2, 2010
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Richard Engh, Hubert Hertenberger, Konrad Honold, Birgit Masjost, Petra Rueger, Wolfgang Schaefer, Stefan Scheiblich, Manfred Schwaiger
  • HETEROARYL DERIVATIVES AS PROTEIN KINASE INHIBITORS
    Publication number: 20090318428
    Abstract: Objects of the present invention are the compounds of formula I their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
    Type: Application
    Filed: September 4, 2007
    Publication date: December 24, 2009
    Inventors: Konrad Honold, Wolfgang Schaefer, Stefan Scheiblich
  • Benzamide derivatives, their manufacture and use as pharmaceutical agents
    Patent number: 7618964
    Abstract: Objects of the present invention are the compounds of formula I their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
    Type: Grant
    Filed: December 22, 2005
    Date of Patent: November 17, 2009
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Konrad Honold, Klaus Kaluza, Birgit Masjost, Wolfgang Schaefer, Stefan Scheiblich
  • 6-(2-ALKYL-PHENYL)-PYRIDO[2,3-D]PYRIMIDINES USEFUL AS PROTEIN KINASE INHIBITORS
    Publication number: 20090247518
    Abstract: Objects of the present invention are the compounds of formula I their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
    Type: Application
    Filed: March 26, 2009
    Publication date: October 1, 2009
    Inventors: Konrad Honold, Wolfgang Schaefer, Stefan Scheiblich
  • Azabenzimidazole Derivatives, Their Manufacture and Use as Anti-Cancer Agents
    Publication number: 20090227578
    Abstract: Objects of the present invention are the compounds of formula I their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
    Type: Application
    Filed: July 28, 2006
    Publication date: September 10, 2009
    Inventors: Richard Engh, Hubert Hertenberger, Konrad Honold, Birgit Masjost, Petra Rueger, Wolfgang Schaefer, Stefan Scheiblich, Manfred Schwaiger
  • 6-(2-alkyl-phenyl)-pyrido[2,3-D]pyrimidines useful as protein kinase inhibitors
    Patent number: 7550589
    Abstract: Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
    Type: Grant
    Filed: September 20, 2005
    Date of Patent: June 23, 2009
    Assignee: Hoffman-La Roche Inc.
    Inventors: Konrad Honold, Wolfgang Schaefer, Stefan Scheiblich
  • Amide derivatives of 7-amino-3-phenyl-dihydropyrimido[4,5-d]pyrimidinones, their manufacture and use as pharmaceutical agents
    Patent number: 7494993
    Abstract: The present invention relates to novel amide derivatives of 7-amino-3-phenyl dihydropyrimido[4,5-d]pyrimidinones, to a process for their manufacture, medicaments containing them and their manufacture as well as the use of these compounds as pharmaceutically active agents. The present derivatives are new compounds of the general formula (I).
    Type: Grant
    Filed: August 30, 2005
    Date of Patent: February 24, 2009
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Richard Engh, Hubert Hertenberger, Konrad Honold, Birgit Masjost, Petra Rueger, Wolfgang Schaefer, Stefan Scheiblich, Manfred Schwaiger
  • 7H-Pyrido[3,4-D]Pyrimidin-8-Ones, Their Manufacture and Use as Protein Kinase Inhibitors
    Publication number: 20090030020
    Abstract: Objects of the present invention are the compounds of formula I their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, medicaments containing them and their manufacture, as well as the use of the above compounds in the control or prevention of illnesses such as cancer.
    Type: Application
    Filed: January 29, 2007
    Publication date: January 29, 2009
    Inventors: Konrad Honold, Jane Paul, Carl Roeschlaub, Wolfgang Schaefer, Stefan Scheiblich, Thomas Von Hirschheydt, Alan Whittle
  • Method for the recombinant production and purification of protein kinases
    Patent number: 7393936
    Abstract: A method for the recombinant production and purification of a protein kinase selected from the group consisting of tyrosine protein kinases and serine/threonine kinases by expressing a nucleic acid encoding said kinase in a microbial host cell, forming inclusion bodies containing said kinase, isolating, solubilizing, naturing, and purifying said kinase wherein said purification is performed by hydrophobic interaction with an hydrophobic adsorbent under conditions whereby at least 70% of said protein kinase are not bound to said adsorbent and the protein kinase not bound to said adsorbent is recovered.
    Type: Grant
    Filed: December 1, 2004
    Date of Patent: July 1, 2008
    Assignee: Hoff Hoffmann-La Roche Inc.
    Inventors: Hubert Hertenberger, Konrad Honold, Christian Klein, Petra Rueger
  • Benzamide Derivatives, Their Manufacture and Use as Pharmaceutical Agents
    Publication number: 20080039460
    Abstract: Objects of the present invention are the compounds of formula I their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
    Type: Application
    Filed: December 22, 2005
    Publication date: February 14, 2008
    Inventors: Konrad Honold, Klaus Kaluza, Birgit Masjost, Wolfgang Schaefer, Stefan Scheiblich
  • Amide Derivatives of 7-Amino-3-Phenyl-Dihydropyrimido[4,5-D]Pyrimidinones, Their Manufacture and Use as Pharmaceutical Agents
    Publication number: 20080032970
    Abstract: The present invention relates to novel amide derivatives of 7-amino-3-phenyl dihydropyrimido[4,5-d]pyrimidinones, to a process for their manufacture, medicaments containing them and their manufacture as well as the use of these compounds as pharmaceutically active agents. The present derivatives are new compounds of the general formula (I).
    Type: Application
    Filed: August 30, 2005
    Publication date: February 7, 2008
    Inventors: Richard Engh, Hubert Hertenberger, Konrad Honold, Birgit Masjost, Petra Rueger, Wolgfang Schaefer, Stefan Scheiblich, Manfred Schwaiger
  • Heterocyclic Carbamate Derivatives, Their Manufacture And Use As Pharmaceutical Agents
    Publication number: 20080009492
    Abstract: Objects of the present invention are the compounds of formula I their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
    Type: Application
    Filed: December 22, 2005
    Publication date: January 10, 2008
    Inventors: Konrad Honold, Klaus Kaluza, Birgit Masjost, Wolfgang Schaefer, Stefan Scheiblich
  • 6-(2-Alkyl-Phenyl)-Pyrido[2,3-D]Pyrimidines useful as Proteine Kinase Inhibitors
    Publication number: 20070259899
    Abstract: Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
    Type: Application
    Filed: September 20, 2005
    Publication date: November 8, 2007
    Inventors: Konrad Honold, Wolfgang Schaefer, Stefan Scheiblich
  • Amide Derivatives of 3-Phenyl-Dihydropyrimido[4,5-D]Pyrimidinones, Their Manufacture and Use as Pharmaceutical Agents
    Publication number: 20070232611
    Abstract: The present invention relates to novel amide derivatives of 3-phenyl dihydropyrimido[4,5-d]pyrimidinones, to a process for their manufacture, medicaments containing them and their manufacture as well as the use of these compounds as pharmaceutically active agents. The present derivatives are new compounds of the general formula (I).
    Type: Application
    Filed: August 30, 2005
    Publication date: October 4, 2007
    Applicant: F. HOFFMANN-LA ROCNE AG
    Inventors: Richard Engh, Hubert Hertenberger, Konrad Honold, Birgit Masjost, Petra Rueger, Wolfgang Schaefer, Stefan Scheiblich, Manfred Schwaiger