Patents by Inventor Konrad Howitz

Konrad Howitz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions for manipulating the lifespan and stress response of cells and organisms
    Publication number: 20060084135
    Abstract: Provided herein are methods and compositions for modulating the activity of sirtuin deacetylase protein family members; p53 activity; apoptosis; lifespan and sensitivity to stress of cells and organisms. Exemplary methods comprise contacting a cell with an activating compound, such as a flavone, stilbene, flavanone, isoflavone, catechin, chalcone, tannin or anthocyanidin; or an inhibitory compound, such as a sphingolipid, e.g., sphingosine.
    Type: Application
    Filed: July 1, 2004
    Publication date: April 20, 2006
    Inventors: Konrad Howitz, Robert Zipkin
  • Sirtuin related therapeutics and diagnostics for neurodegenerative diseases
    Publication number: 20060025337
    Abstract: Provided herein are methods and compositions for modulating the activity of sirtuin deacetylase protein family members; p53 activity; apoptosis; lifespan and sensitivity to stress of cells and organisms. Exemplary methods comprise contacting a cell with an activating compound, such as a flavone, stilbene, flavanone, isoflavone, catechin, chalcone, tannin or anthocyanidin; or an inhibitory compound, such as a sphingolipid, e.g., sphingosine. Also disclosed herein are methods for treating, preventing or diagnosing a disease associated with neuronal cell death, e.g., a neurodegenerative disease.
    Type: Application
    Filed: March 7, 2005
    Publication date: February 2, 2006
    Applicant: President and Fellows of Harvard College
    Inventors: David Sinclair, Li-Huei Tsai, Minh Nguyen, Konrad Howitz, Robert Zipkin, Kevin Bitterman
  • Compositions and methods for selectively activating human sirtuins
    Publication number: 20060014705
    Abstract: Methods for identifying selective activators of SIRT5 and/or SIRT1 and methods for using these selective activators in the modulation of SIRT5 and/or SIRT1 are provided.
    Type: Application
    Filed: June 24, 2005
    Publication date: January 19, 2006
    Inventors: Konrad Howitz, Robert Zipkin
  • Compositions for manipulating the lifespan and stress response of cells and organisms
    Publication number: 20050136537
    Abstract: Provided herein are methods and compositions for modulating the activity of sirtuin deacetylase protein family members; p53 activity; apoptosis; lifespan and sensitivity to stress of cells and organisms. Exemplary methods comprise contacting a cell with an activating compound, such as a flavone, stilbene, flavanone, isoflavone, catechin, chalcone, tannin or anthocyanidin; or an inhibitory compound, such as a sphingolipid, e.g., sphingosine.
    Type: Application
    Filed: July 2, 2004
    Publication date: June 23, 2005
    Applicants: President and Fellows of Harvard College, BIOMOL International L.P.
    Inventors: David Sinclair, Konrad Howitz, Robert Zipkin