Patents by Inventor Konstantin Chumakov

Konstantin Chumakov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Test for virulent genomic nucleotide 472 revertants in attenuated live poliovirus type 3 vaccines
    Patent number: 5550018
    Abstract: The present invention comprises the method of evaluation of the safety of live attenuated vaccines based on detection and measurement of the incidence of genetic changes associated with reversion to virulence in vaccine microorganisms. The method based on PCR and restriction enzyme analysis was developed and used for determination of the proportion of mutants contributing to neurovirulence of type 3 live oral poliovirus vaccine. The correlation between the neurovirulence of OPV lots revealed by the monkey test and the abundance of mutant virus containing cytidine in the position 472 was discovered. The amount of these mutants increases upon passages of the virus in cell cultures at a rate dependent on the cell type, cultivation conditions and the seed virus stock.
    Type: Grant
    Filed: May 18, 1994
    Date of Patent: August 27, 1996
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Inessa Levenbook, Konstantin Chumakov, Laurie Powers, Igor Roninson