Patents by Inventor Konstantin V. Balakin

Konstantin V. Balakin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitor of ATP-dependent cellular reverse transporters and method for producing same
    Patent number: 10987429
    Abstract: A group of chiral conjugates (optically active hybrid molecules) of oligoetherpolyol structure are inhibitors of ATP-dependent reverse transporters of cells (OEP inhibitors). An OEP inhibitor is a conjugate having an equimolar ratio of optically active polyoxypropylene hexol and polyoxypropylene glycol. The produced preparation increases the efficacy of medicines by inhibiting multi-drug resistance mechanisms of cells. It may be used in biology, pharmacology, pharmaceutics, medicine, and agriculture. The inhibitor is produced by hydroxypropylation of a mixture of sorbitol and a bifunctional oxygen-containing compound in the presence of a hydroxide of an alkaline or alkaline earth metal. The bifunctional oxygen-containing compound used may be water, propylene glycol, dipropylene glycol, tripropylene glycol, tetrapropylene glycol, pentapropylene glycol, hexapropylene glycol, heptapropylene glycol or a mixture thereof.
    Type: Grant
    Filed: April 30, 2019
    Date of Patent: April 27, 2021
    Assignees: AO “Tatkhimfarmpreparaty”, Kazan Federal University
    Inventors: Yurij G. Shtyrlin, Al'fiya G. Iksanova, Yurij V. Badeev, Konstantin V. Balakin
  • Method of use of novel naproxen derivatives
    Patent number: 10688084
    Abstract: A new derivative of naproxen, 3-((S)-2-(6-methoxynaphth-2-yl) propanoyloxy)-4,5-bis (((S)-2-(6-methoxynaphth-2-yl) propanoyloxy)-methyl)-2-methylpyridinium (S)-2-(6-methoxynaphth-2-yl) propanoate has a high anti-inflammatory, analgesic and antipyretic activity, as well as low acute toxicity and gastrotoxicity, it can be used in the pharmaceutical industry, medicine and veterinary.
    Type: Grant
    Filed: December 16, 2019
    Date of Patent: June 23, 2020
    Assignees: AO “Tatkhimfarmpreparaty”, Kazan Federal University
    Inventors: Yurij G. Shtyrlin, Roman S. Pavel'ev, Al'fiya G. Iksanova, Nikita V. Shtyrlin, Mikhail V. Pugachev, Konstantin V. Balakin, Aleksandr M. Ajmaletdinov, Il'nur M. Ganiev, Al'bina G. Malan'eva
  • Naproxen-Based Non-Steroidal Anti-Inflammatory Drug with Low Gastric Toxicity
    Publication number: 20200147067
    Abstract: A new derivative of naproxen, 3-((S)-2-(6-methoxynaphth-2-yl) propanoyloxy)-4,5-bis (((S)-2-(6-methoxynaphth-2-yl) propanoyloxy)-methyl)-2-methylpyridinium (S)-2-(6-methoxynaphth-2-yl) propanoate has a high anti-inflammatory, analgesic and antipyretic activity, as well as low acute toxicity and gastrotoxicity, it can be used in the pharmaceutical industry, medicine and veterinary.
    Type: Application
    Filed: December 16, 2019
    Publication date: May 14, 2020
    Inventors: Yurij G. SHTYRLIN, Roman S. PAVEL'EV, Al'fiya G. IKSANOVA, Nikita V. SHTYRLIN, Mikhail V. PUGACHEV, Konstantin V. BALAKIN, Aleksandr M. AJMALETDINOV, Il'nur M. GANIEV, Al'bina G. MALAN'EVA
  • Naproxen-based non-steroidal anti-inflammatory drug with low gastric toxicity
    Patent number: 10507202
    Abstract: A new derivative of naproxen, 3-((S)-2-(6-methoxynaphth-2-yl) propanoyloxy)-4,5-bis (((S)-2-(6-methoxynaphth-2-yl) propanoyloxy)-methyl)-2-methylpyridinium (S)-2-(6-methoxynaphth-2-yl) propanoate has a high anti-inflammatory, analgesic and antipyretic activity, as well as low acute toxicity and gastrotoxicity, it can be used in the pharmaceutical industry, medicine and veterinary.
    Type: Grant
    Filed: April 30, 2019
    Date of Patent: December 17, 2019
    Assignees: AO “Tatkhimfarmpreparaty”, Kazan Federal University
    Inventors: Yurij G. Shtyrlin, Roman S. Pavel'Ev, Al'fiya G. Iksanova, Nikita V. Shtyrlin, Mikhail V. Pugachev, Konstantin V. Balakin, Aleksandr M. Ajmaletdinov, Il'nur M. Ganiev, Al'bina G. Malan'Eva
  • Inhibitor of ATP-Dependent Cellular Reverse Transporters and Method for Producing Same
    Publication number: 20190255184
    Abstract: A group of chiral conjugates (optically active hybrid molecules) of oligoetherpolyol structure are inhibitors of ATP-dependent reverse transporters of cells (OEP inhibitors). An OEP inhibitor is a conjugate having an equimolar ratio of optically active polyoxypropylene hexol and polyoxypropylene glycol. The produced preparation increases the efficacy of medicines by inhibiting multi-drug resistance mechanisms of cells. It may be used in biology, pharmacology, pharmaceutics, medicine, and agriculture. The inhibitor is produced by hydroxypropylation of a mixture of sorbitol and a bifunctional oxygen-containing compound in the presence of a hydroxide of an alkaline or alkaline earth metal. The bifunctional oxygen-containing compound used may be water, propylene glycol, dipropylene glycol, tripropylene glycol, tetrapropylene glycol, pentapropylene glycol, hexapropylene glycol, heptapropylene glycol or a mixture thereof.
    Type: Application
    Filed: April 30, 2019
    Publication date: August 22, 2019
    Inventors: Yurij G. SHTYRLIN, Al'fiya G. IKSANOVA, Yurij V. BADEEV, Konstantin V. BALAKIN
  • Naproxen-Based Non-Steroidal Anti-Inflammatory Drug with Low Gastric Toxicity
    Publication number: 20190255030
    Abstract: A new derivative of naproxen, 3-((S)-2-(6-methoxynaphth-2-yl) propanoyloxy)-4,5-bis (((S)-2-(6-methoxynaphth-2-yl) propanoyloxy)-methyl)-2-methylpyridinium (S)-2-(6-methoxynaphth-2-yl) propanoate has a high anti-inflammatory, analgesic and antipyretic activity, as well as low acute toxicity and gastrotoxicity, it can be used in the pharmaceutical industry, medicine and veterinary.
    Type: Application
    Filed: April 30, 2019
    Publication date: August 22, 2019
    Inventors: Yurij G. SHTYRLIN, Roman S. PAVEL'EV, Al'fiya G. IKSANOVA, Nikita V. SHTYRLIN, Mikhail V. PUGACHEV, Konstantin V. BALAKIN, Aleksandr M. AJMALETDINOV, Il'nur M. GANIEV, Al'bina G. MALAN'EVA