Patents by Inventor Konstantin V. Pugachev

Konstantin V. Pugachev has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • FLAVIVIRUS VACCINES
    Publication number: 20190192649
    Abstract: The invention provides flavivirus vaccines and methods of making and using these vaccines.
    Type: Application
    Filed: November 26, 2018
    Publication date: June 27, 2019
    Inventors: Thomas P. MONATH, Farshad GUIRAKHOO, Juan ARROYO, Konstantin V. PUGACHEV
  • Flavivirus vaccines
    Patent number: 10172929
    Abstract: The invention provides flavivirus vaccines and methods of making and using these vaccines.
    Type: Grant
    Filed: October 6, 2014
    Date of Patent: January 8, 2019
    Assignee: Sanofi Pasteur Biologics, LLC
    Inventors: Thomas P. Monath, Farshad Guirakhoo, Juan Arroyo, Konstantin V. Pugachev
  • Replication-defective flavivirus vaccines and vaccine vectors
    Patent number: 9217158
    Abstract: This invention provides replication-defective flavivirus vaccines and vaccine vectors, and corresponding compositions and methods.
    Type: Grant
    Filed: October 2, 2012
    Date of Patent: December 22, 2015
    Assignee: Sanofi Pasteur Biologics, LLC
    Inventors: Konstantin V. Pugachev, Maryann Giel-Moloney, Harold Kleanthous, Mark Parrington, Linong Zhang
  • FLAVIVIRUS VACCINES
    Publication number: 20150024004
    Abstract: The invention provides flavivirus vaccines and methods of making and using these vaccines.
    Type: Application
    Filed: October 6, 2014
    Publication date: January 22, 2015
    Inventors: Thomas P. MONATH, Farshad GUIRAKHOO, Juan ARROYO, Konstantin V. PUGACHEV
  • Recombinant vaccines
    Patent number: 8871222
    Abstract: The invention provides recombinant flavivirus vaccines that can be used in the prevention and treatment of flavivirus infection. The vaccines of the invention contain recombinant flaviviruses including attenuating mutations.
    Type: Grant
    Filed: February 27, 2012
    Date of Patent: October 28, 2014
    Assignee: Sanofi Pasteur Biologics, LLC
    Inventors: Konstantin V. Pugachev, Farshad Guirakhoo, Thomas P. Monath
  • Flavivirus vaccines
    Patent number: 8852914
    Abstract: The invention provides flavivirus vaccines and methods of making and using these vaccines.
    Type: Grant
    Filed: November 5, 2012
    Date of Patent: October 7, 2014
    Assignee: Sanofi Pasteur Biologics, LLC
    Inventors: Thomas P. Monath, Farshad Guirakhoo, Juan Arroyo, Konstantin V. Pugachev
  • Replication-defective flavivirus vaccines and vaccine vectors
    Patent number: 8815564
    Abstract: This invention provides replication-defective flavivirus vaccines and vaccine vectors, and corresponding compositions and methods.
    Type: Grant
    Filed: March 16, 2009
    Date of Patent: August 26, 2014
    Assignee: Sanofi Pasteur Biologics, LLC
    Inventors: Konstantin V. Pugachev, Alexander A. Rumyantsev, Maryann Giel-Moloney, Harold Kleanthous
  • Vaccines against japanese encephalitis virus and west nile virus
    Patent number: 8691550
    Abstract: The invention provides attenuated Flavivirus vaccines, such as vaccines against Japanese encephalitis virus and West Nile virus, as well as methods of making and using these vaccines.
    Type: Grant
    Filed: October 3, 2011
    Date of Patent: April 8, 2014
    Assignee: Sanofi Pasteur Biologics, LLC
    Inventors: Farshad Guirakhoo, J. Jian Liu, John A. Catalan, Thomas P. Monath, Konstantin V. Pugachev
  • Replication-Defective Flavivirus Vaccines and Vaccine Vectors
    Publication number: 20130243812
    Abstract: This invention provides replication-defective flavivirus vaccines and vaccine vectors, and corresponding compositions and methods.
    Type: Application
    Filed: October 2, 2012
    Publication date: September 19, 2013
    Applicant: Sanofi Pasteur Biologics, LLC
    Inventor: Konstantin V. Pugachev
  • Recombinant Flavivirus Vaccines
    Publication number: 20120288520
    Abstract: The invention provides recombinant flavivirus vaccines that can be used in the prevention and treatment of flavivirus infection. The vaccines of the invention contain recombinant flaviviruses including attenuating mutations.
    Type: Application
    Filed: February 27, 2012
    Publication date: November 15, 2012
    Applicant: Sanofi Pasteur Biologics, LLC
    Inventors: Konstantin V. Pugachev, Farshad Guirakhoo, Thomas P. Monath
  • Vaccines Against Japanese Encephalitis Virus and West Nile Virus
    Publication number: 20120201852
    Abstract: The invention provides attenuated Flavivirus vaccines, such as vaccines against Japanese encephalitis virus and West Nile virus, as well as methods of making and using these vaccines.
    Type: Application
    Filed: October 3, 2011
    Publication date: August 9, 2012
    Applicant: Sanofi Pasteur Biologics Co.
    Inventors: Farshad Guirakhoo, J. Jian Liu, John A. Catalan, Thomas P. Monath, Konstantin V. Pugachev
  • Replication-Defective Flavivirus Vaccine Vectors Against Respiratory Syncytial Virus
    Publication number: 20120128713
    Abstract: Replication-defective vaccine vectors against respiratory syncytial virus (RSV) are disclosed. Corresponding compositions and methods employing the vaccine vectors are also disclosed.
    Type: Application
    Filed: March 16, 2010
    Publication date: May 24, 2012
    Applicants: Sanofi Pasteur Limited, Sanofi Pasteur Biologics Co.
    Inventors: Konstantin V. Pugachev, Alexander A. Rumyantsev, Maryann Giel-Moloney, Mark Parrington, Linong Zhang
  • Recombinant flavivirus vaccines
    Patent number: 8124398
    Abstract: The invention provides recombinant flavivirus vaccines that can be used in the prevention and treatment of flavivirus infection. The vaccines of the invention contain recombinant flaviviruses including attenuating mutations.
    Type: Grant
    Filed: April 24, 2006
    Date of Patent: February 28, 2012
    Assignee: Sanofi Pasteur Biologics Co.
    Inventors: Konstantin V. Pugachev, Farshad Guirakhoo, Thomas P. Monath
  • Vaccines against Japanese encephalitis virus and West Nile virus
    Patent number: 8029802
    Abstract: The invention provides attenuated Flavivirus vaccines, such as vaccines against Japanese encephalitis virus and West Nile virus, as well as methods of making and using these vaccines.
    Type: Grant
    Filed: October 19, 2005
    Date of Patent: October 4, 2011
    Assignee: Sanofi Pasteur Biologics Co.
    Inventors: Farshad Guirakhoo, J. Jian Liu, John A. Catalan, Thomas P. Monath, Konstantin V. Pugachev
  • Replication-Defective Flavivirus Vaccines and Vaccine Vectors
    Publication number: 20110135686
    Abstract: This invention provides replication-defective flavivirus vaccines and vaccine vectors, and corresponding compositions and methods.
    Type: Application
    Filed: March 16, 2009
    Publication date: June 9, 2011
    Applicant: Sanofi Pasteur Biologics Co.
    Inventors: Konstantin V. Pugachev, Alexander A. Rumyantsev, Maryann Giel-Moloney, Harold Kleanthous
  • Viral Vectors and Methods of Use
    Publication number: 20110003884
    Abstract: This invention relates to viral vectors and methods employing these vectors. The vectors of the invention can be base on flaviviruses, such as chimeric flavi viruses, which may be used to deliver heterologous antigens, such as influenza virus antigens.
    Type: Application
    Filed: February 11, 2008
    Publication date: January 6, 2011
    Inventors: Konstantin V. Pugachev, Qing-sheng Gao, Alexander A. Rumyantsev
  • Construction of Recombinant Virus Vaccines by Direct Transposon-Mediated Insertion of Foreign Immunologic Determinants into Vector Virus Proteins
    Publication number: 20100184832
    Abstract: The invention provides viral vectors, such as chimeric flavivirus vectors, including foreign peptides inserted into the target proteins of the vectors, methods of making and using these vectors, and compositions including the vectors.
    Type: Application
    Filed: July 16, 2007
    Publication date: July 22, 2010
    Applicant: Sanofi Pasteur Biologics Co.
    Inventors: Konstantin V. Pugachev, Alexander A. Rumyantsev
  • Recombinant Flavivirus Vaccines
    Publication number: 20080175862
    Abstract: The invention provides recombinant flavivirus vaccines that can be used in the prevention and treatment of flavivirus infection. The vaccines of the invention contain recombinant flaviviruses including attenuating mutations.
    Type: Application
    Filed: April 24, 2006
    Publication date: July 24, 2008
    Applicant: Acambis Inc.
    Inventors: Konstantin V. Pugachev, Farshad Guirakhoo, Thomas P. Monath
  • Highly infectious rubella virus DNA constructs and methods of production
    Patent number: 6958237
    Abstract: Highly infectious rubella virus cDNA clones derived from infectious cDNA clone having a low specific infectivity and methods of obtaining highly infectious rubella virus cDNA clones. Togavirus expression vectors of improved stability for the expression of live, attenuated togavirus and a foreign gene, based on the nucleic acid sequence of an infectious rubella virus clone and contain a togavirus non-structural protein open reading frame; an expression element for expression of a foreign gene; a foreign gene or a multiple cloning site for insertion of a foreign gene; an expression element for the expression of the live, attenuated togavirus; and a togavirus structural protein open reading frame. The expression element is either a subgenomic promoter or an internal ribosome entry site (IRES). Administration of the vector as an immunization agents is useful for the induction of immuity against the togavirus, the foreign gene, or both.
    Type: Grant
    Filed: October 15, 2002
    Date of Patent: October 25, 2005
    Assignee: Georgia State Univesity Research Foundation, Inc.
    Inventors: Teryl K. Frey, Konstantin V. Pugachev, Emily S. Abernathy, Wen-Pin Tzeng
  • Highly infectious rubella virus DNA constructs and methods of production
    Publication number: 20030215795
    Abstract: Highly infectious rubella virus cDNA clones derived from infectious cDNA clone having a low specific infectivity and methods of obtaining highly infectious rubella virus cDNA clones. Togavirus expression vectors of improved stability for the expression of live, attenuated togavirus and a foreign gene, based on the nucleic acid sequence of an infectious rubella virus clone and contain a togavirus non-structural protein open reading frame; an expression element for expression of a foreign gene; a foreign gene or a multiple cloning site for insertion of a foreign gene; an expression element for the expression of the live, attenuated togavirus; and a togavirus structural protein open reading frame. The expression element is either a subgenomic promoter or an internal ribosome entry site (IRES). Administration of the vector as an immunization agents is useful for the induction of immuity against the togavirus, the foreign gene, or both.
    Type: Application
    Filed: February 24, 2003
    Publication date: November 20, 2003
    Inventors: Teryl K. Frey, Konstantin V. Pugachev, Emily S. Abernathy, Wen-Pin Tzeng