Patents by Inventor Konstantinos Makris

Konstantinos Makris has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for aiding differential diagnosis of stroke
    Patent number: 10753948
    Abstract: The present invention provides a method of aiding the differential diagnosis of haemorrhagic stroke, ischemic stroke and a transient ischemic attack in a patient who has suffered or is suffering a stroke. The method comprises: (i) determining the concentration of the biomarkers VCAM-1, GFAP and CRP in an ex vivo sample obtained from the patient; and (ii) establishing the statistical significance of the concentration of the biomarkers. Optionally, the method further comprises steps of (iii) determining the concentration of the biomarkers IL-6 and sTNFR1 in an ex vivo sample obtained from the patient; (iv) determining the gender of the patient; and (v) establishing the statistical significance of the concentration of the five biomarkers, in conjunction with the patient's gender. The present invention also provides substrates comprising probes for VCAM-1, GFAP and CRP for use in a method for aiding the differential diagnosis of stroke.
    Type: Grant
    Filed: June 4, 2014
    Date of Patent: August 25, 2020
    Assignee: Randox Laboratories Ltd.
    Inventors: Ivan McConnell, John Lamont, Peter Fitzgerald, Konstantinos Makris
  • GFAP ACCUMULATING IN STROKE
    Publication number: 20190346458
    Abstract: The use of glial fibrillary acidic protein as a marker of pernicious stroke is described
    Type: Application
    Filed: November 20, 2017
    Publication date: November 14, 2019
    Inventors: Stephen Peter Fitzgerald, Ivan McConnell, Ciaran Richardson, John Lamont, Konstantinos Makris
  • Method for Aiding Differential Diagnosis of Stroke
    Publication number: 20160139147
    Abstract: The present invention provides a method of aiding the differential diagnosis of haemorrhagic stroke, ischemic stroke and a transient ischemic attack in a patient who has suffered or is suffering a stroke. The method comprises: (i) determining the concentration of the biomarkers VCAM-1, GFAP and CRP in an ex vivo sample obtained from the patient; and (ii) establishing the statistical significance of the concentration of the biomarkers. Optionally, the method further comprises steps of (iii) determining the concentration of the biomarkers IL-6 and sTNFR1 in an ex vivo sample obtained from the patient; (iv) determining the gender of the patient; and (v) establishing the statistical significance of the concentration of the five biomarkers, in conjunction with the patient's gender. The present invention also provides substrates comprising probes for VCAM-1, GFAP and CRP for use in a method for aiding the differential diagnosis of stroke.
    Type: Application
    Filed: June 4, 2014
    Publication date: May 19, 2016
    Inventors: Ivan McConnell, John Lamont, Peter Fitzgerald, Konstantinos Makris
  • Mutations in IKK&ggr;
    Patent number: 6689564
    Abstract: The present invention relates to compositions and methods involving IKK&ggr; mutants. In particular, the present invention provides methods and compositions, including transgenic animals, suitable for use in determining means to treat, control, and/or prevent incontinentia pigmenti (IP). The present invention also provides methods to detect the presence of mutations in the IKK&ggr; gene and protein.
    Type: Grant
    Filed: June 15, 2001
    Date of Patent: February 10, 2004
    Assignee: The Regents of the University of California
    Inventors: Konstantinos Makris, Michael Karin
  • Mutations in IKK gamma
    Publication number: 20020056150
    Abstract: The present invention relates to compositions and methods involving IKK&ggr; mutants. In particular, the present invention provides methods and compositions, including transgenic animals, suitable for use in determining means to treat, control, and/or prevent incontinentia pigmenti (IP). The present invention also provides methods to detect the presence of mutations in the IKK&ggr; gene and protein.
    Type: Application
    Filed: June 15, 2001
    Publication date: May 9, 2002
    Applicant: Regents of the University of California
    Inventors: Konstantinos Makris, Michael Karin