Patents by Inventor Koretake Anami

Koretake Anami has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5151497
    Abstract: Novel peptide derivatives of the following formula ##STR1## wherein each symbol is as defined in the specification, pharmaceutically acceptable acid addition salts thereof and analogous copounds thereof.Since the derivatives and their pharmaceutically acceptable acid addition salts of the present invention possess stronger actions on central nervous system (e.g. antagonistic action against hypothermia, locomotor stimulant action, signal reflex stimulant action), they are of use as a therapeutic medicament for central nervous disorders such as impaired consciousness, depression, hypomnesia, the like in association association with schizophrenia, melancholia, senile dementia, sequelae of cerebrovascular disorders, head trauma, epilepsy and spinocerebellar degeneracy.
    Type: Grant
    Filed: July 12, 1991
    Date of Patent: September 29, 1992
    Assignees: Japan Tobacco Inc., Yoshotomi Pharmaceutical Industries, Ltd.
    Inventors: Itsuo Uchida, Akira Saito, Akihiro Yasuda, Kunio Iwata, Hiroaki Hari, Katsuyoshi Hara, Mutsuyoshi Matsushita, Koretake Anami, Junichi Haruta, Noboru Furukawa
  • Patent number: 5118811
    Abstract: Amino acid derivatives of the formula ##STR1## wherein: Q is W--(CH.sub.2).sub.m --(A).sub.n --CO--B-- whereinA is oxygen atom or --NH--;B is ##STR2## or --(CH.sub.2).sub.l -- wherein X is sulfur atom or --CH.sub.2 --, and l is an integer from 1 to 3;W is ##STR3## wherein Hal is halogen atom; n is an integer of 0 or 1; andm is an integer from 0 to 3;Y is sulfur atom or --CH.sub.2 --; andR is hydrogen atom, formyl group, C.sub.1-5 alkoxycarbonyl group, --C.tbd.N or ##STR4## wherein R.sup.1 is hydrogen atom, andR.sup.2 is hydroxyl group, C.sub.1-5 alkylcarboxy group, phenylcarboxy group, C.sub.1-5 alkoxy group or phenyl C.sub.1-5 alkoxy group;with the proviso that when R is hydrogen atom, formyl group or C.sub.1-5 alkoxycarbonyl group, W is ##STR5## The compounds mentioned above specifically inhibit prolyl endopeptidase activity and are useful as agents for the treatment and prevention of dementia and amnesia.
    Type: Grant
    Filed: December 12, 1990
    Date of Patent: June 2, 1992
    Assignees: Japan Tobacco Inc., Yoshitomi Pharmaceutical Industries, Ltd.
    Inventors: Itsuo Uchida, Koji Kobayashi, Kazuhiko Nishii, Kunio Iwata, Shin Hara, Koretake Anami
  • Patent number: 5055464
    Abstract: Benzolactam compounds of the general formula ##STR1## or isomers thereof as well as salts thereof inclusive of hydrates and/or solvates forms thereof, and benzolactam compounds of the general formula ##STR2## wherein each of the symbols is as defined in the specification. The compound (I) exhibit antiamnesic activity, and are useful as brain function-improving drugs. The compounds (a) and (b) are useful as an intermediate for said compounds (I). Futher, the compound (a) show diuretic or antiulcer activity, and are useful as a diuretic or antiulcer agent.
    Type: Grant
    Filed: January 25, 1990
    Date of Patent: October 8, 1991
    Assignee: Yoshitomi Pharmaceutical Industries Ltd.
    Inventors: Shu Murakami, Tsuguo Ikebe, Ichiro Hakamada, Koretake Anami
  • Patent number: 4514403
    Abstract: A hydrouracil compound of the formula: ##STR1## or a pharmaceutically acceptable acid addition salt thereof, wherein A represents --CH.dbd.CH--CH.sub.2 -- or --CH.sub.2 CH.sub.2 --, and R represents hydrogen or methyl. Such compounds are useful as analgesics.
    Type: Grant
    Filed: September 17, 1981
    Date of Patent: April 30, 1985
    Assignee: Yoshitomi Pharmaceutical Industries Ltd.
    Inventors: Chiaki Tashiro, Takeshi Kawakita, Ichiro Horii, Koretake Anami