Patents by Inventor Koretsugu Ogata

Koretsugu Ogata has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11101125
    Abstract: A sample plate for a solid sample includes a plate-shaped main body and lid. The main body has a concave portion, in which a sample placement platform shaped like a cylinder protrudes from the central area of the bottom surface of the concave portion. The lid has a funnel-shaped opening bored at a position immediately above the concave portion. The diameter of the opening on the lower side is approximately the same as that of the sample placement platform. After a sample, e.g. a biological tissue section, is placed in the concave portion, the lid is closed. Then, the lower wall surface of the lid surrounding the opening presses the sample downward. The sample is thereby sandwiched between the lower wall surface and the sample placement platform. A solvent for ionization is injected into the opening whose lower side is thus closed by the sample.
    Type: Grant
    Filed: August 31, 2017
    Date of Patent: August 24, 2021
    Assignee: SHIMADZU CORPORATION
    Inventors: Tasuku Murata, Takeshi Uchida, Koretsugu Ogata
  • Publication number: 20210175064
    Abstract: A sample plate for a solid sample includes a plate-shaped main body and lid. The main body has a concave portion, in which a sample placement platform shaped like a cylinder protrudes from the central area of the bottom surface of the concave portion. The lid has a funnel-shaped opening bored at a position immediately above the concave portion. The diameter of the opening on the lower side is approximately the same as that of the sample placement platform. After a sample, e.g. a biological tissue section, is placed in the concave portion, the lid is closed. Then, the lower wall surface of the lid surrounding the opening presses the sample downward. The sample is thereby sandwiched between the lower wall surface and the sample placement platform. A solvent for ionization is injected into the opening whose lower side is thus closed by the sample.
    Type: Application
    Filed: May 31, 2017
    Publication date: June 10, 2021
    Applicant: SHIMADZU CORPORATION
    Inventors: Tasuku MURATA, Takeshi UCHIDA, Koretsugu OGATA
  • Patent number: 10950423
    Abstract: The user specifies regions of interest (ROIs) such as a region where a large amount of compound to be identified is estimated to be included and a region where the compound is overlapped with another compound on one or more specific MS images, and specifies addition or subtraction of the ROIs. For each of the specified ROIs, an average MS/MS spectrum is calculated from MS/MS spectrum data at measurement points in the regions, and the average MS/MS spectra at the ROIs are subjected to addition or subtraction, to obtain an MS/MS spectrum. By addition between the ROIs, the intensity of peak derived from the target compound can be increased. By subtraction between the ROIs, a peak derived from the other compound overlapped with the target compound can be removed. When the MS/MS spectrum after addition or subtraction is subjected to library search for identification, a score indicating the similarity of the spectrum is higher than the conventional score, and the identification accuracy can be improved.
    Type: Grant
    Filed: August 26, 2016
    Date of Patent: March 16, 2021
    Assignee: SHIMADZU CORPORATION
    Inventors: Masahiro Ikegami, Koretsugu Ogata
  • Publication number: 20200346232
    Abstract: In a system for depositing a matrix film by nebulizing a matrix solution onto a sample plate P to which a sample is attached, a chamber 10 housing a sample stage 11 to which a sample plate is attached, a nebulizing nozzle 20 for nebulizing the matrix solution onto the sample stage, a gas inlet 14 formed in the chamber, replacement gas suppliers 40, 41, 42, 43, 47 for supplying a replacement gas to the gas inlet, and replacement gas diffusers 15, 17 for diffusing a flow of the replacement gas in the chamber are provided. According to such a configuration, it is possible to perform gas replacement in the chamber while preventing the formation of a humidity gradient due to the gas flow of the replacement gas. As a result, the humidity in the chamber is kept constant and uniform, and the size of a crystal grain formed on the sample plate and the extraction efficiency of the sample components by the matrix solution can be stabilized.
    Type: Application
    Filed: November 30, 2017
    Publication date: November 5, 2020
    Applicant: SHIMADZU CORPORATION
    Inventors: Kenta TERASHIMA, Koretsugu OGATA
  • Patent number: 10550418
    Abstract: An apparatus that identifies the type of a test cell based on a result obtained by performing mass spectrometry on the test cell includes a higher-level database, which contains mass lists that each list ion mass values of constituent components of a known cell, and a lower-level database, which contains partial mass lists that each list only strain-specific ion mass values out of the ion mass values. The higher-level database is first searched for a test mass list which is created from the result of the mass spectrometry performed on the test cell, and based on a result of the search, an organism species to be searched in the following search operation is determined. Mass values common to the organism species are subsequently deleted from the mass list for the test cell, and the mass list having undergone the deletion operation is used to search the lower-level database.
    Type: Grant
    Filed: June 28, 2019
    Date of Patent: February 4, 2020
    Assignee: SHIMADZU CORPORATION
    Inventors: Noriyuki Ojima, Koretsugu Ogata, Keisuke Shima, Hiroto Tamura, Akifumi Hosoda, Yudai Hotta
  • Publication number: 20190369128
    Abstract: A sample group forming section 24 classifies samples derived from microorganisms into groups according to empirical information showing the species or strain of each sample. A differential analysis section 27 performs a differential analysis using a peak matrix created based on the result of the grouping. An operator enters group rearrangement conditions concerning the drug resistance of microorganisms. Under the entered conditions, a sample group rearranging/rearrangement-cancelling section 25 rearranges the already formed groups by selecting or merging groups using another kind of previously registered empirical information which shows the drug resistance of each group. The differential analysis section 27 performs a differential analysis using a peak matrix newly created based on the result of the rearrangement of the groups. Thus, differential analysis results concerning the resistance to different drugs can be sequentially acquired as the group rearrangement condition is successively changed.
    Type: Application
    Filed: November 9, 2017
    Publication date: December 5, 2019
    Applicant: Shimadzu Corporation
    Inventors: Yoshihiro YAMADA, Koretsugu OGATA, Hiroto TAMURA, Teruyo KATO
  • Publication number: 20190323054
    Abstract: An apparatus that identifies the type of a test cell based on a result obtained by performing mass spectrometry on the test cell includes a higher-level database, which contains mass lists that each list ion mass values of constituent components of a known cell, and a lower-level database, which contains partial mass lists that each list only strain-specific ion mass values out of the ion mass values. The higher-level database is first searched for a test mass list which is created from the result of the mass spectrometry performed on the test cell, and based on a result of the search, an organism species to be searched in the following search operation is determined. Mass values common to the organism species are subsequently deleted from the mass list for the test cell, and the mass list having undergone the deletion operation is used to search the lower-level database.
    Type: Application
    Filed: June 28, 2019
    Publication date: October 24, 2019
    Applicant: SHIMADZU CORPORATION
    Inventors: Noriyuki OJIMA, Koretsugu OGATA, Keisuke SHIMA, Hiroto TAMURA, Akifumi HOSODA, Yudai HOTTA
  • Publication number: 20190287774
    Abstract: An optical image formation unit forms an optical image of an interest region based on data obtained through image acquiring of the surface of a specimen. An intensity image production unit produces an intensity image illustrating ion spatial distribution at an m/z value specified based on mass spectrum data obtained for each measurement point in the interest region. An image superimposing processor produces an image by superimposing the optical image and the intensity image at a predetermined m/z value in accordance with an instruction from a user, and a display processor displays the image on a screen of a display unit. When the user performs a predetermined operation, the display processor displays a set screen for adjusting the brightness and contrast of the optical image, and an image parameter adjustment unit changes the brightness and contrast of the optical image in the superimposed image independently from the intensity image.
    Type: Application
    Filed: August 26, 2016
    Publication date: September 19, 2019
    Applicant: SHIMADZU CORPORATION
    Inventors: Koretsugu OGATA, Masahiro IKEGAMI
  • Patent number: 10385379
    Abstract: An apparatus that identifies the type of a test cell based on a result obtained by performing mass spectrometry on the test cell includes a higher-level database, which contains mass lists that each list ion mass values of constituent components of a known cell, and a lower-level database, which contains partial mass lists that each list only strain-specific ion mass values out of the ion mass values. The higher-level database is first searched for a test mass list which is created from the result of the mass spectrometry performed on the test cell, and based on a result of the search, an organism species to be searched in the following search operation is determined. Mass values common to the organism species are subsequently deleted from the mass list for the test cell, and the mass list having undergone the deletion operation is used to search the lower-level database.
    Type: Grant
    Filed: October 17, 2012
    Date of Patent: August 20, 2019
    Assignee: SHIMADZU CORPORATION
    Inventors: Noriyuki Ojima, Koretsugu Ogata, Keisuke Shima, Hiroto Tamura, Akifumi Hosoda, Yudai Hotta
  • Publication number: 20190198304
    Abstract: The compound list stored in identification information memory is populated with theoretical masses associated with a variety of compounds, as well as information such as the type of matrix capable of detecting said compound, potential neutral loss, etc. The adduct ion list, meanwhile, is populated with theoretical masses associated with a variety of adduct ions, as well as other information such as types of matrices capable of producing adducts, etc. When a user specifies a peak on the mass spectrum for a compound search, compound candidate search portion extracts combination candidates based on how well the measured m/z value of the specified peak matches the m/z value for combinations of compounds in the compound list and adduct ions in the adduct ion list, while the type of matrix used during measurement serves as a condition to narrow down the combinations. Display processing portion displays a list of the search results.
    Type: Application
    Filed: September 1, 2016
    Publication date: June 27, 2019
    Applicant: SHIMADZU CORPORATION
    Inventors: Masahiro IKEGAMI, Koretsugu OGATA
  • Publication number: 20190189414
    Abstract: The user specifies regions of interest (ROIs) such as a region where a large amount of compound to be identified is estimated to be included and a region where the compound is overlapped with another compound on one or more specific MS images, and specifies addition or subtraction of the ROIs. For each of the specified ROIs, an average MS/MS spectrum is calculated from MS/MS spectrum data at measurement points in the regions, and the average MS/MS spectra at the ROIs are subjected to addition or subtraction, to obtain an MS/MS spectrum. By addition between the ROIs, the intensity of peak derived from the target compound can be increased. By subtraction between the ROIs, a peak derived from the other compound overlapped with the target compound can be removed. When the MS/MS spectrum after addition or subtraction is subjected to library search for identification, a score indicating the similarity of the spectrum is higher than the conventional score, and the identification accuracy can be improved.
    Type: Application
    Filed: August 26, 2016
    Publication date: June 20, 2019
    Applicant: SHIMADZU CORPORATION
    Inventors: Masahiro IKEGAMI, Koretsugu OGATA
  • Publication number: 20170294297
    Abstract: After a sample such as a biomedical tissue section is attached to an electrically-conductive slide glass (S1), the film layer of a matrix substance is appropriately formed by vapor deposition so as to cover the sample (S2). The crystal of the matrix substance in the film layer is very fine and uniform. Subsequently, the slide glass on which the matrix film layer is formed is placed in a vaporized solvent atmosphere, and the solvent infiltrates into the matrix film layer (S3). When the solvent sufficiently infiltrated is vaporized, a substance to be measured in the sample takes in the matrix and re-crystallized. Furthermore, the matrix film layer is formed again on the surface by the vapor deposition (S4). The added matrix film layer absorbs excessive energy of a laser beam during MALDI, which suppresses the denaturation of the substance to be measured and the like, so that high detection sensitivity can be achieved while high spatial resolution is maintained.
    Type: Application
    Filed: June 23, 2017
    Publication date: October 12, 2017
    Applicants: SHIMADZU CORPORATION
    Inventors: Koretsugu OGATA, Kazuteru TAKAHASHI, Akiko KUBO, Makoto SUEMATSU, Takushi YAMAMOTO
  • Patent number: 9721776
    Abstract: After a sample such as a biomedical tissue section is attached to an electrically-conductive slide glass (S1), the film layer of a matrix substance is appropriately formed by vapor deposition so as to cover the sample (S2). The crystal of the matrix substance in the film layer is very fine and uniform. Subsequently, the slide glass on which the matrix film layer is formed is placed in a vaporized solvent atmosphere, and the solvent infiltrates into the matrix film layer (S3). When the solvent sufficiently infiltrated is vaporized, a substance to be measured in the sample takes in the matrix and re-crystallized. Furthermore, the matrix film layer is formed again on the surface by the vapor deposition (S4). The added matrix film layer absorbs excessive energy of a laser beam during MALDI, which suppresses the denaturation of the substance to be measured and the like, so that high detection sensitivity can be achieved while high spatial resolution is maintained.
    Type: Grant
    Filed: April 4, 2014
    Date of Patent: August 1, 2017
    Assignees: SHIMADZU CORPORATION, KEIO UNIVERSITY
    Inventors: Koretsugu Ogata, Kazuteru Takahashi, Akiko Kubo, Makoto Suematsu, Takushi Yamamoto
  • Patent number: 9550184
    Abstract: Disclosed herein is a reactor plate which prevents the entry of foreign matter from the outside and the pollution of a surrounding environment. A reactor plate (1) includes a reaction well (5), a reaction well channel connected to the reaction well (5), and reaction well air vent channels (19) and (21) connected to the reaction well (5). The reaction well channel has a main channel (13), a metering channel (15) branched off the main channel (13), and an injection channel (17) of which one end is connected to the metering channel (15) and the other end is connected to the reaction well (5). The main channel (13) and the reaction well air vent channel (21) can be hermetically sealed.
    Type: Grant
    Filed: November 19, 2007
    Date of Patent: January 24, 2017
    Assignee: SHIMADZU CORPORATION
    Inventors: Nobuhiro Hanafusa, Koretsugu Ogata, Takahiro Nishimoto, Masaki Kanai
  • Publication number: 20160035553
    Abstract: After a sample such as a biomedical tissue section is attached to an electrically-conductive slide glass (S1), the film layer of a matrix substance is appropriately formed by vapor deposition so as to cover the sample (S2). The crystal of the matrix substance in the film layer is very fine and uniform. Subsequently, the slide glass on which the matrix film layer is formed is placed in a vaporized solvent atmosphere, and the solvent infiltrates into the matrix film layer (S3). When the solvent sufficiently infiltrated is vaporized, a substance to be measured in the sample takes in the matrix and re-crystallized. Furthermore, the matrix film layer is formed again on the surface by the vapor deposition (S4). The added matrix film layer absorbs excessive energy of a laser beam during MALDI, which suppresses the denaturation of the substance to be measured and the like, so that high detection sensitivity can be achieved while high spatial resolution is maintained.
    Type: Application
    Filed: April 4, 2014
    Publication date: February 4, 2016
    Applicants: KEIO UNIVERSITY, SHIMADZU CORPORATION
    Inventors: Koretsugu OGATA, Kazuteru TAKAHASHI, Akiko KUBO, Makoto SUEMATSU, Takuji YAMAMOTO
  • Publication number: 20140288852
    Abstract: An apparatus that identifies the type of a test cell based on a result obtained by performing mass spectrometry on the test cell includes a higher-level database, which contains mass lists that each list ion mass values of constituent components of a known cell, and a lower-level database, which contains partial mass lists that each list only strain-specific ion mass values out of the ion mass values. The higher-level database is first searched for a test mass list which is created from the result of the mass spectrometry performed on the test cell, and based on a result of the search, an organism species to be searched in the following search operation is determined. Mass values common to the organism species are subsequently deleted from the mass list for the test cell, and the mass list having undergone the deletion operation is used to search the lower-level database.
    Type: Application
    Filed: October 17, 2012
    Publication date: September 25, 2014
    Applicant: SHIMADZU CORPORATION
    Inventors: Noriyuki Ojima, Koretsugu Ogata, Keisuke Shima, Hiroto Tamura, Akifumi Hosoda, Yudai Hotta
  • Patent number: 8333930
    Abstract: Upper space on the front surface side of a reaction plate, provided with at least a reaction container causing reaction in a sample and a reagent container containing a reagent used for reaction with the sample, is covered with an airtight cover. A dispensation tip (20) for transporting liquid on the reaction plate is arranged in such a way that the distal end side is located on the inside of the covered space and the proximal portion is located on the outside.
    Type: Grant
    Filed: February 14, 2007
    Date of Patent: December 18, 2012
    Assignee: Shimadzu Corporation
    Inventors: Nobuhiro Hanafusa, Koretsugu Ogata, Koji Tanimizu, Tomoichi Takahashi
  • Patent number: 8293521
    Abstract: It is intended to easily dispense a minute amount of nonvolatile liquid. In a preferred embodiment, in dispensing of mineral oil (nonvolatile liquid), dispensing is conducted in the condition that the amount of air contained in a tip (70) is small by aspirating a larger amount of mineral oil (40) than a single dispensing amount in the tip (70) of a nozzle (28).
    Type: Grant
    Filed: March 30, 2006
    Date of Patent: October 23, 2012
    Assignees: Shimadzu Corporation, Toppan Printing Co., Ltd., Riken
    Inventors: Nobuhiro Hanafusa, Koretsugu Ogata, Ryuh Konoshita, Yusuke Nakamura, Yozo Ohnishi
  • Patent number: 8257966
    Abstract: Disclosed is a reaction kit for preventing the entry of foreign matter into a reaction plate from the outside and the pollution of a surrounding environment. The reaction kit includes: a reaction plate (2) having, on the top surface side thereof, a reaction container (4) for carrying out the reaction of a sample and a reagent container (12) containing a reagent used for the reaction of a sample and sealed with a film (14); a dispensation tip (20) arranged on the top surface side of the reaction plate (2); a cover (24) covering a space above the top surface of the reaction plate (2) and movably supporting the dispensation tip (20) so that a distal end thereof is located inside the space covered with the cover (4) and a proximal end thereof is located outside the space; and a sample container (32) for introducing a sample into the space covered with the cover (24) from the outside through a sealable opening (31) provided in a part of the cover (24).
    Type: Grant
    Filed: February 14, 2007
    Date of Patent: September 4, 2012
    Assignee: Shimadzu Corporation
    Inventors: Nobuhiro Hanafusa, Koretsugu Ogata, Koji Tanimizu, Tomoichi Takahashi, Atsushi Inami, Ryuh Konoshita, Masami Maekawa, Takanori Mochizuki
  • Patent number: 8168135
    Abstract: Intrusion of foreign matters from the outside of a reaction container plate and environmental contamination onto the outside are prevented. The reaction container plate (1) comprises a container base (3) having a reaction container (5), a channel base (11) having an introduction hole (11b) above the reaction container (5) and arranged on the surface of the container base (3), and a channel cover (13) arranged on the channel base (11) in order to form in cooperation with the surface of the channel base, an introduction channel (15) passing above the introduction hole (11b). The channel (13) is formed to be enclosed. The introduction hole (11b) does not allow liquid to pass under an introduction pressure state in the channel (15) where the liquid is introduced into the channel (15) but allows the liquid in the channel (15) to pass to the reaction container (5) side under a pressurized state where the inside of the channel (15) is pressurized higher than the introduction pressure.
    Type: Grant
    Filed: October 23, 2007
    Date of Patent: May 1, 2012
    Assignee: Shimadzu Corporation
    Inventors: Nobuhiro Hanafusa, Koretsugu Ogata